Pullulan-Based Hydrogels in Wound Healing and Skin Tissue Engineering Applications: A Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4962 - 4962

Published: March 4, 2023

Wound healing is a complex process of overlapping phases with the primary aim creation new tissues and restoring their anatomical functions. dressings are fabricated to protect wound accelerate process. Biomaterials used design dressing wounds could be natural or synthetic as well combination both materials. Polysaccharide polymers have been fabricate dressings. The applications biopolymers, such chitin, gelatin, pullulan, chitosan, greatly expanded in biomedical field due non-toxic, antibacterial, biocompatible, hemostatic, nonimmunogenic properties. Most these form foams, films, sponges, fibers drug carrier devices, skin tissue scaffolds, Currently, special focus has directed towards fabrication based on synthesized hydrogels using polymers. high-water retention capacity makes them potent candidates for they provide moist environment remove excess fluid, thereby accelerating healing. incorporation pullulan different, naturally occurring polymers, currently attracting much attention antimicrobial, antioxidant Despite valuable properties it also some limitations, poor mechanical high cost. However, improved by blending different Additionally, more investigations required obtain derivatives suitable quality engineering applications. This review summarizes then examines other biocompatible chitosan discusses facile approaches oxidative modification pullulan.

Language: Английский

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Nanocellulose from agro-waste: a comprehensive review of extraction methods and applications

Reviews in Environmental Science and Bio/Technology, Journal Year: 2023, Volume and Issue: 22(1), P. 1 - 27

Published: Jan. 19, 2023

Language: Английский

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Nano/Micro-Structural Supramolecular Biopolymers: Innovative Networks with the Boundless Potential in Sustainable Agriculture

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 8, 2024

Abstract Sustainable agriculture plays a crucial role in meeting the growing global demand for food while minimizing adverse environmental impacts from overuse of synthetic pesticides and conventional fertilizers. In this context, renewable biopolymers being more sustainable offer viable solution to improve agricultural sustainability production. Nano/micro-structural supramolecular are among these innovative that much sought after their unique features. These biomaterials have complex hierarchical structures, great stability, adjustable mechanical strength, stimuli-responsiveness, self-healing attributes. Functional molecules may be added flexible structure, enabling novel uses. This overview scrutinizes how nano/micro-structural radically alter farming practices solve lingering problems sector namely production, soil health, resource efficiency. Controlled bioactive ingredient released allows tailored administration agrochemicals, agents, biostimulators as they enhance nutrient absorption, moisture retention, root growth. protect crops by appending antimicrobials biosensing entities eco-friendliness supports agriculture. Despite potential, further studies warranted understand optimize usage domain. effort seeks bridge knowledge gap investigating applications, challenges, future prospects sector. Through experimental investigations theoretical modeling, aims provide valuable insights into practical implementation optimization agriculture, ultimately contributing development eco-friendly solutions productivity impact.

Language: Английский

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An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

Macromolecular Bioscience, Journal Year: 2022, Volume and Issue: 22(7)

Published: April 14, 2022

A wound can be surgical cuts from an operation or due to accident and trauma. The infected wound, as a result of bacteria growth within the damaged skin, interrupts natural healing process significantly impacts quality life. Wound dressing is important segment skincare industry with its economic burden estimated at $ 20.4 billion (in 2021) in global market. results recent clinical trials suggest that use modern dressings easiest, most accessible, cost-effective way treat chronic wounds and, hence, holds significant promise. With sheer number market, selection correct confusing for clinicians healthcare workers. aim this research review widely used types antibacterial dressings, well emerging products, their efficiency mode action. In review, introducing antibiotics nanoparticles two clinically categories agents focused. perspectives challenges paving future field are also discussed.

Language: Английский

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Design and fabrication strategies of cellulose nanocrystal-based hydrogel and its highlighted application using 3D printing: A review

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 301, P. 120351 - 120351

Published: Nov. 17, 2022

Language: Английский

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High-Release, Residue-Free Polysaccharide Hydrogel for Refrigerated Food Preservation

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(4), P. 6035 - 6046

Published: Jan. 23, 2023

Hundreds of millions tons food resources are wasted annually due to microbial contamination. Effective packaging can prevent contamination and wastage. However, traditional has the problem low release bioactive substances. This study aimed prepare a pH-responsive polysaccharide hydrogel (GDPP) by double cross-linking ester hydrogen bonds that could result in high substances no residual peeling. The infrared results showed existence hydrogel, scanning electron microscopy porous network structure hydrogel. texture profile analysis self-healing tests GDPP-1 good mechanical properties. Moreover, bond broke response pH environment, improving swelling properties equilibrium ratio was greater than 1000%, rate more 80%. Notably, peeling experiments only 0.1 N external force needed separate from salmon, residue observed on salmon surface. final freshness test effectively prolonged shelf life refrigerated for 3-6 days. These findings indicated hydrogels be used extend food. Furthermore, their advantages cost simple preparation better meet needs industry applications.

Language: Английский

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Evaluation of composition effects on the tissue-adhesive, mechanical and physical properties of physically crosslinked hydrogels based on chitosan and pullulan for wound healing applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133857 - 133857

Published: Sept. 1, 2024

Language: Английский

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Facile fabrication of a thermal/pH responsive IPN hydrogel drug carrier based on cellulose and chitosan through simultaneous dual-click strategy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 827 - 841

Published: Aug. 28, 2024

Language: Английский

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Characterization and chemical modification of pullulan produced from a submerged culture of Aureobasidium pullulans ATCC 15233

Polymer Testing, Journal Year: 2022, Volume and Issue: 114, P. 107686 - 107686

Published: July 5, 2022

In this paper, the pullulan produced by A. pullulans ATCC 15233 was characterized and chemically modified. The derivative synthesized with an acetylation reaction a degree of substitution (DS) 2.90. Its structural elucidation performed using infrared (IR) nuclear magnetic resonance (NMR) spectroscopy. results showed signs α (1–4) (1–6) glycosidic bonds, typical pullulan. molecular weight (MW) 93.47 kDa. thermal analysis conducted indicated increased stability (Td) glass transition temperature (Tg) due to acetylation. Homogeneous morphologies samples under were obtained scanning electron microscopy (SEM). mechanical properties film exhibited tensile strength (TS) values 1.70 ± 0.48 MPa elongation at break (% E) 11.89%. Likewise, acetate recorded TS 1.23 0.09 % E 1.25%. suggest that physicochemical biosynthesized derivatives can be considered in development biomaterials.

Language: Английский

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Pullulan hydrogels as drug release platforms in biomedicine

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 89, P. 105066 - 105066

Published: Oct. 18, 2023

It is increasingly urgent to develop new therapeutic systems combat the spreading and evolution of various pathologies globally. Nonspecific therapies and/or insufficient medication biodistribution might hinder patient's recovery. In this sense, a targeted controlled delivery biomolecules allows overcoming limitations conventional systems, taking user one step closer successful treatment disease. Hydrogels have been highlighted for their drug abilities, particularly tunable properties, like hydration capacity, biodegradability, release kinetics, etc., that can be adjusted desired needs. Additionally, they produced from either natural synthetic polymers, with natural-origin sources providing exceptional features biodegradation acceptable integration in biological systems. One those polymers pullulan, biodegradable, biocompatible hemocompatible material, multiple uses biomedicine. Investigations into pullulan-based hydrogels progressively increased over last few decades. This review addresses pullulan biomedical engineering, emphasizing its properties processing hydrogel original or derivative forms.

Language: Английский

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