Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1674 - 1674
Published: June 7, 2023
The
therapeutic
efficiency
of
plant
extracts
has
been
limited
by
their
poor
pharmaceutical
availability.
Hydrogels
have
promising
potential
to
be
applied
as
wound
dressings
due
high
capacity
absorb
exudates
and
enhanced
performance
in
loading
releasing
extracts.
In
this
work,
pullulan/poly
(vinyl
alcohol)
(P/PVA)
hydrogels
were
first
prepared
using
an
eco-friendly
method
based
on
both
a
covalent
physical
cross-linking
approach.
Then,
the
loaded
with
hydroalcoholic
extract
Calendula
officinalis
simple
post-loading
immersion
method.
Different
capacities
investigated
terms
physico-chemical
properties,
chemical
composition,
mechanical
water
absorption.
exhibited
hydrogen
bonding
interactions
between
polymer
extract.
retention
well
properties
decreased
increase
amount
hydrogel.
However,
higher
amounts
hydrogel
improved
bioadhesiveness.
release
from
was
controlled
Fickian
diffusion
mechanism.
Extract-loaded
expressed
antioxidant
activity,
reaching
70%
DPPH
radical
scavenging
after
15
min
buffer
solution
at
pH
5.5.
Additionally,
showed
antibacterial
activity
against
Gram-positive
Gram-negative
bacteria
non-cytotoxic
HDFa
cells.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(4), P. 750 - 750
Published: March 30, 2022
Skin
tissue
regeneration
is
one
of
the
population’s
most
common
problems,
and
complications
that
may
appear
in
healing
process
can
have
detrimental
consequences.
An
alternative
to
conventional
treatments
could
be
represented
by
sustainable
materials
based
on
natural
products,
such
as
honey
its
derivates
(propolis,
royal
jelly,
bee
pollen,
beeswax,
venom).
They
exhibit
significant
inhibitory
activities
against
bacteria
great
potential
dermal
regeneration.
Research
pharmaceutical
field
demonstrates
medication
combined
with
products
deliver
better
results.
The
advantages
include
minimizing
side
effects
maintaining
same
effectiveness
using
low
concentrations
antibiotic,
anti-inflammatory,
or
chemotherapy
drugs.
Several
studies
suggested
replace
antimicrobial
activity
efficiency
antibiotics,
but
further
investigation
needed
establish
a
topical
mixture’s
potential,
including
honey,
propolis.
Bee
seem
complete
each
other’s
deficiencies,
their
mixture
impact
wound
process.
topic
addressed
this
paper
highlights
usefulness
propolis,
venom
re-epithelization
bacterial
infections.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(15), P. 2990 - 2990
Published: July 24, 2022
Dressings
made
with
polyurethanes
have
been
found
to
exhibit
good
and
varied
biological
properties
that
make
them
candidates
for
this
application.
However,
as
has
seen,
the
wound-healing
process
is
complex,
which
includes
four
different
stages.
So
far,
design
evaluation
of
polyurethane
wound
dressing
focused
on
achieving
(mechanical,
physicochemical,
biological),
but
each
separates
from
others
or
even
directed
at
only
one
stages
skin
wound-healing.
Therefore,
aim
systematic
review
explore
applications
in
dressings
determine
whether
could
be
designed
cover
more
than
stage
The
PRISMA
guidelines
were
followed.
current
research
field
does
not
consider
separately,
covering
all
healing
a
single
material
necessary
replace
short
periods
time.
Additionally,
little
emphasis
placed
hemostasis
further
characterization
still
needed
correlate
mechanical
physicochemical
Current
demonstrates
an
effort
characterize
materials
physiochemically
mechanically,
terms
their
properties,
most
literature
based
performance
histological
tests
explants
morphologically
probing
compromised
tissues,
give
indication
potential
use
generation
dressings.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1674 - 1674
Published: June 7, 2023
The
therapeutic
efficiency
of
plant
extracts
has
been
limited
by
their
poor
pharmaceutical
availability.
Hydrogels
have
promising
potential
to
be
applied
as
wound
dressings
due
high
capacity
absorb
exudates
and
enhanced
performance
in
loading
releasing
extracts.
In
this
work,
pullulan/poly
(vinyl
alcohol)
(P/PVA)
hydrogels
were
first
prepared
using
an
eco-friendly
method
based
on
both
a
covalent
physical
cross-linking
approach.
Then,
the
loaded
with
hydroalcoholic
extract
Calendula
officinalis
simple
post-loading
immersion
method.
Different
capacities
investigated
terms
physico-chemical
properties,
chemical
composition,
mechanical
water
absorption.
exhibited
hydrogen
bonding
interactions
between
polymer
extract.
retention
well
properties
decreased
increase
amount
hydrogel.
However,
higher
amounts
hydrogel
improved
bioadhesiveness.
release
from
was
controlled
Fickian
diffusion
mechanism.
Extract-loaded
expressed
antioxidant
activity,
reaching
70%
DPPH
radical
scavenging
after
15
min
buffer
solution
at
pH
5.5.
Additionally,
showed
antibacterial
activity
against
Gram-positive
Gram-negative
bacteria
non-cytotoxic
HDFa
cells.
