Two‐Dimensional Nanomaterials‐Based Polymer Nanocomposites for Biomedical Applications DOI
Swapnita Patra, Krishna Manjari Sahu,

Shuvendu Shuvankar Purohit

et al.

Published: May 20, 2024

Two-dimensional (2D) nanostructured materials have taken a special interest among researchers due to their layered structural feature with high aspect ratio showing versatile properties. nanomaterials like graphene, graphene oxide (GO), reduced (rGO), nanoclay, double hydroxide (LDH), metal organic framework (MOF), graphitic carbon nitride (g-C 3 N 4 ), hexagonal boron (h-BN), MXene, transition dichalcogenide (TMD), black phosphorus (BP), (TMO), and covalent (COF) are potential reinforcements in polymer nanocomposites (PNCs) by which different properties thermal properties, mechanical strength, gas barrier flame retarding nature, antibacterial behavior of PNCs enhanced, enabling application the biomedical field. When 2D reinforced polymers such as chitosan, poly(lactic acid) (PLA), poly(acrylic acid)(PAA), poly(vinyl alcohol) (PVA), poly(glycolic (PGA), poly(methyl methacrylate) (PMMA), albumin, then prepared become more useful for applications compared other reinforcing nanomaterials. The present chapter focuses on state-of-the-art nanomaterials-based drug delivery, tissue engineering, gene therapy, wound healing, biosensing. From critical analysis, it is found that sandwiched laminar structure unique factor change towards applications. Depending interfacial interaction surface polymer, graphene-based affinity Different analytically discussed inclusion schemes table better understanding readers.

Language: Английский

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review DOI

Nur Hidayah Shahemi,

Mohd Muzamir Mahat, Nurul Ain Najihah Asri

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(7), P. 4045 - 4085

Published: June 26, 2023

Spinal cord injury (SCI) causes severe motor or sensory damage that leads to long-term disabilities due disruption of electrical conduction in neuronal pathways. Despite current clinical therapies being used limit the propagation cell tissue damage, need for neuroregenerative remains. Conductive hydrogels have been considered a promising therapy their ability provide pro-regenerative microenvironment and flexible structure, which conforms complex SCI lesion. Furthermore, conductivity can be utilized noninvasive signaling dictating behavior. However, guide directional axon growth reach distal end complete nerve reconnection remains critical challenge. In this Review, we highlight recent advances conductive hydrogels, including incorporation materials, fabrication techniques, cross-linking interactions. We also discuss important characteristics designing regenerative therapy. propose insights into properties hydrogel could implemented as guidance applications. Specifically, practical implications findings field, potential conclude are further research is needed optimize design application.

Language: Английский

Citations

16
Polycaprolactone/graphene oxide/acellular matrix nanofibrous scaffolds with antioxidant and promyelinating features for the treatment of peripheral demyelinating diseases DOI Creative Commons

Aishwarya Nagarajan,

Nasera Rizwana, Michelle Abraham

et al.

Journal of Materials Science Materials in Medicine, Journal Year: 2023, Volume and Issue: 34(10)

Published: Oct. 5, 2023

Peripheral demyelinating diseases entail damage to axons and Schwann cells in the peripheral nervous system. Because of poor prognosis lack a cure, this group has global impact. The primary underlying cause these involves inability remyelinate damaged insulating myelin around axons, resulting neuronal death over time. In past decade, extensive research been directed direction focusing on their physiological neuroprotective effects neurons One dysregulation remyelinating function associated with oxidative stress. Tissue-engineered biodegradable scaffolds that can stimulate remyelination response have proposed as potential treatment strategy for diseases. However, strategies developed date primarily focussed either or stress isolation. Here, we multifunctional nanofibrous scaffold material biochemical cues tackle both one matrix. We using polycaprolactone (PCL) foundation loaded antioxidant graphene oxide (GO) coated bioscaffold cell acellular vitro studies revealed properties bioscaffold. Based results, approach be promising biomaterial treating

Language: Английский

Citations

16
Graphene-Oxide Peptide-Containing Materials for Biomedical Applications DOI Open Access

Andreea Gostaviceanu,

Simona Gavrilaș, Lucian Copolovici

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10174 - 10174

Published: Sept. 22, 2024

This review explores the application of graphene-based materials (GBMs) in biomedicine, focusing on graphene oxide (GO) and its interactions with peptides proteins. GO, a versatile nanomaterial oxygen-containing functional groups, holds significant potential for biomedical applications but faces challenges related to toxicity environmental impact. Peptides proteins can be functionalized GO surfaces through various methods, including non-covalent such as π–π stacking, electrostatic forces, hydrophobic interactions, hydrogen bonding, van der Waals well covalent bonding reactions involving amide bond formation, esterification, thiol chemistry, click chemistry. These approaches enhance GO’s functionality several key areas: biosensing sensitive biomarker detection, theranostic imaging that integrates diagnostics therapy real-time treatment monitoring, targeted cancer where deliver drugs directly tumor sites while being tracked by techniques like MRI photoacoustic imaging. Additionally, GO-based scaffolds are advancing tissue engineering aiding tissues’ bone, muscle, nerve regeneration, their antimicrobial properties improving infection-resistant medical devices. Despite potential, addressing stability scalability is essential fully harness benefits GBMs healthcare.

Language: Английский

Citations

4
Exploring the Potential of Nano-Biomaterials in Tissue Engineering DOI

Giriraj Pandey,

Tejaswini Kolipaka,

Vivek Phatale

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

4
Advancements in Graphene-Based Composites: A Review of the Emerging Applications in Healthcare DOI Creative Commons

Farwa Batool,

Saz Muhammad,

Rabia Muazzam

et al.

Smart Materials in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Protein‐DNA Competition at the Bio‐Nano Interface: Structural and Biological Insights From Graphene Oxide Coronas DOI Creative Commons
Erica Quagliarini, Francesca Giulimondi, Serena Renzi

et al.

Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Understanding interactions between nanomaterials and biomolecules is essential for advancing biomedical nanotechnologies. This study investigates how double‐stranded DNA of varying sizes affects the protein corona (PC) surrounding Graphene Oxide (GO) nanosheets in DNA‐supplemented human plasma. The findings reveal that plays a pivotal role modulating PC composition through dynamic competition governed by factors like surface charge, affinity, fragment size. At lower concentrations, proteins binding sites on GO leads to predominantly composed proteins, with some molecules also bound. However, as concentration increases beyond threshold, shift occurs. increasingly outcompetes sites, resulting two‐component enriched both proteins. Notably, proportion within progressively rising concentration, while content decreases. interplay has significant biological implications. A monotonic increase Toll‐like receptor 9 (TLR9) activation observed increases. As its influence cellular responses are crucial, this emphasizes relevance exploring at bio‐nano interface advancement these applications.

Language: Английский

Citations

0
Porous Biomaterials for Tissue Engineering DOI Creative Commons

Robabehbeygom Ghafelehbashi

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Biomaterials have experienced significant growth in recent decades. Porous biomaterials demonstrated the ability to create intricate spatial configurations with three dimensions, duplicate physical characteristics of natural tissues, enhance transport large molecular structures and cells through interconnected structures, serve as biologically compatible implants that may or not interact host organism. This section will present a historical perspective on evolution discuss latest advancements production porous biomaterials. The utilization these materials spans wide range clinical applications, along their associated benefits obstacles.

Language: Английский

Citations

0
Advantages and limitations/challenges of protein-based nanocomposite DOI
Khalid Umar,

Tabassum Parveen,

Showkat Ahmad Bhawani

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 37 - 67

Published: Jan. 1, 2025

Language: Английский

Citations

0
Current Utilization of Gel-Based Scaffolds and Templates in Foot and Ankle Surgery—A Review DOI Creative Commons
Julia E. Ralph, Bradley J. Lauck,

Carey Colson

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 316 - 316

Published: April 24, 2025

As tissue engineering and regenerative medicine (TERM) continues to revolutionize surgery, there is also growing interest in applying these advancements foot ankle surgery. The purpose of this article provide a comprehensive review the types gel scaffolds templates, their applications challenges with current utilization, future directions TERM With multiple compelling scaffold prospects across numerous natural, synthetic, hybrid polymers currently utilized TERM, promising results have been described treatment osteoarthritis (OA) osteochondral lesions (OCLs). However, concerns material biocompatibility, structural integrity, feasibility during degradation still exist limit extent utilization. researchers continue develop enhanced formulations that address issues, are many opportunities increase

Language: Английский

Citations

0
Application of Unsupervised Learning for the Evaluation of Aerogels’ Efficiency towards Dye Removal—A Principal Component Analysis (PCA) Approach DOI Creative Commons
Khaled Younes,

Yahya Kharboutly,

Mayssara Antar

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(4), P. 327 - 327

Published: April 12, 2023

Water scarcity is a growing global issue, particularly in areas with limited freshwater sources, urging for sustainable water management practices to insure equitable access all people. One way address this problem implement advanced methods treating existing contaminated offer more clean water. Adsorption through membranes technology an important treatment technique, and nanocellulose (NC)-, chitosan (CS)-, graphene (G)- based aerogels are considered good adsorbents. To estimate the efficiency of dye removal mentioned aerogels, we intend use unsupervised machine learning approach known as "Principal Component Analysis". PCA showed that chitosan-based ones have lowest regeneration efficiencies, along moderate number regenerations. NC2, NC9, G5 preferred where there high adsorption energy membrane, porosities could be tolerated, but allows lower efficiencies contaminants. NC3, NC5, NC6, NC11 even low surface area. In brief, presents powerful tool unravel towards removal. Hence, several conditions need when employing or manufacturing investigated aerogels.

Language: Английский

Citations

10