International Journal of Polymeric Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 16
Published: Jan. 22, 2024
Bone
tissue
engineering
(BTE)
applications
and
regenerative
strategies
have
been
used
to
improve
the
clinical
practice
of
repairing
large
bone
defects
associated
with
surgical
resections,
congenital
malformations,
trauma.
The
scaffolds
are
designed
stimulate
a
biological
response,
including
cell
interactions,
guide
regeneration
by
functioning
as
artificial
biomimetic
extracellular
matrixes.
Polymeric
biomaterials
suitable
for
since
they
possess
both
chemical
physical
properties,
enabling
control
shape,
morphology,
biodegradability,
which
makes
them
applications.
In
vivo
animal
models
were
studied
collagen,
chitosan,
poly
(lactic
acid)
(PLA)
high
density
polyethylene
(HDPE),
four
most
common
polymers
employed
in
engineering.
Through
analysis
results
this
review,
studies
can
provide
large-scale
evaluation
possibility
achieving
optimal
bone-forming
capabilities
capabilities.
Furthermore,
review
will
serve
an
essential
reference
well
contribute
development
novel
investigations
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(2)
Published: Dec. 1, 2022
Bone
degeneration
associated
with
various
diseases
is
increasing
due
to
rapid
aging,
sedentary
lifestyles,
and
unhealthy
diets.
Living
bone
tissue
has
bioelectric
properties
critical
remodeling,
under
pathological
conditions
results
in
significant
changes
these
properties.
There
growing
interest
utilizing
biomimetic
electroactive
biomaterials
that
recapitulate
the
natural
electrophysiological
microenvironment
of
healthy
promote
repair.
This
review
first
summarizes
etiology
degenerative
such
as
type
II
diabetes,
osteoporosis,
periodontitis,
osteoarthritis,
rheumatoid
arthritis,
osteomyelitis,
metastatic
osteolysis.
Next,
diverse
array
synthetic
therapeutic
potential
are
discussed.
Putative
mechanistic
pathways
by
which
can
mitigate
critically
examined,
including
enhancement
osteogenesis
angiogenesis,
suppression
inflammation
osteoclastogenesis,
well
their
anti-bacterial
effects.
Finally,
limited
research
on
utilization
treatment
aforementioned
examined.
Previous
studies
have
mostly
focused
using
treat
traumatic
injuries.
It
hoped
this
will
encourage
more
efforts
use
for
treating
conditions.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 695 - 695
Published: Feb. 18, 2023
Modern
drug
discovery
methods
led
to
evolving
new
agents
with
significant
therapeutic
potential.
However,
their
properties,
such
as
solubility
and
administration-related
challenges,
may
hinder
benefits.
Moreover,
advances
in
biotechnology
resulted
the
development
of
a
generation
molecules
short
half-life
that
necessitates
frequent
administration.
In
this
context,
controlled
release
systems
are
required
enhance
treatment
efficacy
improve
patient
compliance.
Innovative
delivery
promising
tools
protect
proteins
peptides
against
proteolytic
degradation
where
is
achievable.
The
present
review
provides
an
overview
different
approaches
used
for
delivery.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(26)
Published: March 28, 2024
Abstract
Over
the
past
few
decades,
significant
progress
in
piezo‐/triboelectric
nanogenerators
(PTEGs)
has
led
to
development
of
cutting‐edge
wearable
technologies.
Nanofibers
with
good
designability,
controllable
morphologies,
large
specific
areas,
and
unique
physicochemical
properties
provide
a
promising
platform
for
PTEGs
various
advanced
applications.
However,
further
nanofiber‐based
is
limited
by
technical
difficulties,
ranging
from
materials
design
device
integration.
Herein,
current
developments
based
on
electrospun
nanofibers
are
systematically
reviewed.
This
review
begins
mechanisms
advantages
nanodevices,
including
high
breathability,
waterproofness,
scalability,
thermal–moisture
comfort.
In
terms
structural
design,
novel
electroactive
structure
assemblies
1D
micro/nanostructures,
2D
bionic
structures,
3D
multilayered
structures
discussed.
Subsequently,
nanofibrous
applications
such
as
energy
harvesters,
personalized
medicine,
personal
protective
equipment,
human–machine
interactions
summarized.
Nanofiber‐based
still
face
many
challenges
efficiency,
material
durability,
stability,
Finally,
research
gap
between
practical
discussed,
emerging
trends
proposed,
providing
some
ideas
intelligent
wearables.
Micromachines,
Journal Year:
2024,
Volume and Issue:
15(4), P. 475 - 475
Published: March 30, 2024
Implantable
biosensors
have
evolved
to
the
cutting-edge
technology
of
personalized
health
care
and
provide
promise
for
future
directions
in
precision
medicine.
This
is
reason
why
these
devices
stand
revolutionize
our
approach
disease
management
offer
insights
into
bodily
functions
ways
that
never
been
possible
before.
review
article
tries
delve
important
developments,
new
materials,
multifarious
applications
biosensors,
along
with
a
frank
discussion
on
challenges
will
face
their
clinical
deployment.
In
addition,
techniques
employed
improvement
sensitivity
specificity
alike
are
focused
this
article,
like
biomarkers
advanced
computational
data
communicational
models.
A
significant
challenge
miniaturized
situ
implants
they
need
be
removed
after
serving
purpose.
Surgical
expulsion
provokes
discomfort
patients,
potentially
leading
post-operative
complications.
Therefore,
biodegradability
an
alternative
method
removal
through
natural
biological
processes.
includes
biocompatible
materials
develop
sensors
remain
body
over
longer
periods
much-reduced
immune
response
better
device
longevity.
However,
implantable
still
its
infancy
compared
conventional
non-biodegradable
ones.
Sensor
design,
morphology,
fabrication,
power,
electronics,
transmission
all
play
pivotal
role
developing
medically
approved
biodegradable
biosensors.
Advanced
material
science
nanotechnology
extended
capacity
different
research
groups
implement
novel
courses
action
design
sensor
components.
But
actualization
such
potential
transformative
nature
sector,
first
place,
surmount
related
biofouling,
managing
guaranteeing
security,
meeting
today’s
rules
regulations.
Solving
problems
will,
therefore,
not
only
enhance
performance
reliability
but
also
facilitate
translation
laboratory
development
clinics,
patients
worldwide
therapeutic
interventions.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: March 22, 2024
Abstract
Nerve
injury
can
lead
to
defects
in
related
motor
functions.
It
is
critical
achieve
long‐term
and
convenient
real‐time
evaluation
of
function
recovery
status
during
nerve
repair.
In
this
study,
an
implantable
PLLA/BTO
piezoelectric
sensor
(PBPS)
with
good
biodegradability
biocompatibility
for
real
time
the
after
developed.
PLLA
fibers
doped
BTO
are
employed
as
material
PBPS,
which
convert
biomechanical
signals
generated
by
motion
into
electrical
signals.
PBPS
be
implant
simultaneously
commonly
used
tissue
scaffolds
treatment
rats
sciatic
injury.
The
linearity
pressure
output
voltage
≈0.9445.
For
effectiveness,
process
progresses,
exhibited
consistency
EMG
signals,
indicating
effectively
function.
Moreover,
integration
wireless
module
break
limitations
space
sensing
realize
rat.
based
on
may
bring
new
ideas
development
bioelectronics.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 22, 2025
Abstract
An
integrated
strategy
that
combines
innovative
electrospinning
technique
with
traditional
hot‐stretching
post‐treatment
is
designed
and
implemented
to
generate
high‐molecular‐weight
poly(l‐lactic‐acid)
(hmwPLLA,
Mw
=
2
80
000
Da)
electrospun
nanofiber‐constructed
yarns
(ENCYs).
The
internal
fiber
diameter
within
the
hmwPLLA
ENCYs
found
increase
gradually
of
solution
concentration.
ENCY
generated
from
a
concentration
10%
(w
v
−1
)
demonstrated
uniform
morphology
an
average
737.7
±
72.2
nm
yarn
454.9
3.5
µm.
Compared
unstretched
ENCY,
increasing
temperature
can
significantly
enhance
orientation
crystallinity.
Moreover,
mechanical
properties
stretched
are
obviously
enhanced
compared
control.
crystallinity
also
be
improved
hot
stretching
rate,
further
resulting
in
obvious
breaking
strength
Young's
modulus.
Importantly,
braided
textiles
made
exhibited
great
biocompatibility
by
effectively
guiding
cell
alignment
supporting
adhesion
proliferation.
In
summary,
high
performance
show
potential
for
future
design
development
advanced
biomedical
textiles.
Applied Surface Science,
Journal Year:
2023,
Volume and Issue:
621, P. 156835 - 156835
Published: Feb. 25, 2023
The
effect
of
the
surface
potential
biomaterials
on
cell
attachment
and
development
in
regenerative
medicine
is
still
an
unexplored
area
driving
many
regeneration
processes,
especially
piezoelectric
bone
tissue.
Within
this
study,
we
electrospun
poly(l-lactide)
scaffolds
constructed
fibers
with
either
higher
(−600
mV)
or
lower
(−300
potential,
which
controlled
by
applied
voltage
polarity
during
their
production.
Interestingly,
way,
performance
PLLA
can
be
enhanced.
direct
measurement
fiber
using
Kelvin
probe
force
microscopy
(KPFM)
showed
a
good
correlation
zeta
analysis.
piezoelectricity
was
verified
piezoresponse
(PFM),
indicating
that
it
enhanced
applying
positive
to
nozzle
electrospinning.
Importantly,
adhesion
assay
significant
osteoblasts
behavior
creating
favorable
bioelectric
microenvironment.
We
observed
initial
cells
first
5
h
no
additional
proliferation,
morphology,
collagen
It
demonstrated
tunable
are
excellent
for
constructing
tissue
engineering
scaffolds.
