Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

Journal of Biological Engineering, Journal Year: 2024, Volume and Issue: 18(1)

Published: April 22, 2024

Abstract There is an increasing demand for innovative strategies that effectively promote osteogenesis and enhance bone regeneration. The critical process of regeneration involves the transformation mesenchymal stromal cells into osteoblasts subsequent mineralization extracellular matrix, making up complex mechanism osteogenesis. Icariin’s diverse pharmacological properties, such as anti-inflammatory, anti-oxidant, osteogenic effects, have attracted considerable attention in biomedical research. Icariin, known its ability to stimulate formation, has been found encourage improve mineralization. Several studies demonstrated effects icariin, which can be attributed hormone-like function. It induce expression BMP-2 BMP-4 mRNAs significantly upregulate Osx at low doses. Additionally, icariin promotes formation by stimulating pre-osteoblastic genes like Osx, RUNX2, collagen type I. However, needs delivered perform promising functions. Encapsulating within nanoplatforms holds significant promise promoting through a range intricate biological effects. When encapsulated nanofibers or nanoparticles, exerts directly cellular level. Recalling inflammation factor influencing regeneration, icariin's anti-inflammatory harnessed amplified when nanoplatforms. Also, while cell adhesion migration are pivotal stages tissue icariin-loaded contribute these processes providing supportive matrix attachment movement. This review comprehensively discusses used osteogenesis, further presenting where field go before clinically.

Language: Английский

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3D Printing and Biomedical Applications of Piezoelectric Composites: A Critical Review

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Abstract Piezoelectric composites have received widespread attentions in the fields of biomedicine and vitro wearable devices due to their ability convert mechanical forces into charge signals. The preparation piezoelectric with complex structures through 3D printing technology can not only effectively improve output, but also enable customized therapeutic applications. This paper first introduces types reviews commonly used preparation, analyzing advantages disadvantages each technology. Then, state‐of‐the‐art biomedical applications composites, including drug sustained‐release, wound healing promotion, bone tissue cells growth promoting, neurorehabilitation stimulating, ultrasonic diagnosis, vivo biosensing sensing, are emphasized. Finally, main factors affecting printed outlooked, an in‐depth discussion on challenges toward analyzed. review is believed provide some fundamental knowledge composites.

Language: Английский

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Towards Stem Cell Therapy for Critical-Sized Segmental Bone Defects: Current Trends and Challenges on the Path to Clinical Translation

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(6), P. 145 - 145

Published: May 27, 2024

The management and reconstruction of critical-sized segmental bone defects remain a major clinical challenge for orthopaedic clinicians surgeons. In particular, regenerative medicine approaches that involve incorporating stem cells within tissue engineering scaffolds have great promise fracture management. This narrative review focuses on the primary components engineering—stem cells, scaffolds, microenvironment, vascularisation—addressing current advances translational regulatory challenges in landscape cell therapy defects. To comprehensively explore this research area offer insights future treatment options surgery, we examined latest developments advancements engineering, focusing those relevance recent years. Finally, present forward-looking perspective using

Language: Английский

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Development of a Nanoparticle System for Controlled Release in Bioprinted Respiratory Scaffolds

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(1), P. 20 - 20

Published: Jan. 12, 2024

The use of nanoparticle systems for the controlled release growth factors is a promising approach to mimicking biochemical environment native tissues in tissue engineering. However, sustaining factor inside an appropriate therapeutic window challenge, particularly bioprinted scaffolds. In this study, chitosan-coated alginate-based system loaded with hepatocyte was developed and then incorporated into kinetics were investigated focus on identifying impact chitosan coating culture conditions. Our results demonstrated that decreased rate lessened initial burst release, while culturing dynamic conditions had no significant compared static nanoparticles bioinks at various concentrations, scaffolds three-dimensional (3D) structure from containing human pulmonary fibroblasts bronchial epithelial cells investigate potential respiratory It found bioink concentration 4 µg/mL better printability other mechanical stability maintained over 14-day period. examination high degree viability proliferation visualization beginning barrier layer. Taken together, study demonstrates allows sustained

Language: Английский

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The osteoconductive properties of graphene-based material surfaces are finely tuned by the conditioning layer and surface chemistry

Materials Advances, Journal Year: 2024, Volume and Issue: 5(11), P. 4772 - 4785

Published: Jan. 1, 2024

The molecular layer that adsorbs on the biomaterial surface upon contacting body tissues and fluids, termed conditioning (CL), influences cell behavior regulating scaffold integration resilience in a patient-specific fashion.

Language: Английский

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Controlled Release of Growth Differentiation Factor 5 from Polyethylene Glycol-Stabilized Amorphous Calcium Phosphate Nanoparticle Electrospun Fibers to Promote Periodontal Bone Regeneration

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

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Metal-Free Antioxidant Nanozyme Incorporating Bioactive Hydrogel as an Antioxidant Scaffold for Accelerating Bone Reconstruction

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123285 - 123285

Published: March 1, 2025

Language: Английский

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Polydopamine grafting polyether ether ketone to stabilize growth factor for efficient osteonecrosis repair

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 29, 2025

Abstract This study examines the biocompatibility, osteogenic potential, and effectiveness of polyether ether ketone (PEEK) composites for treating osteonecrosis, seeking to establish a theoretical basis clinical application. A range PEEK composite materials, including sulfonated (SPEEK), polydopamine-sulfonated (SPEEK-PDA), bone-forming peptide-poly-dopamine-sulfonated (SPEEK-PDA-BFP), vascular endothelial growth factor-poly-dopamine-sulfonated (SPEEK-PDA-VEGF), were constructed by concentrated sulfuric acid sulfonation, polydopamine modification grafting bioactive factors. The experiments involved adult male New Zealand rabbits aged 24–28 weeks weighing 2.6–4 kg. SPEEK-PDA-BFP possesses smallest water contact angle, indicating highest hydrophilicity, with its surface characterized rich density clustered BFP particles. exhibits superior adhesion, proliferation, differentiation capabilities, along pronounced bacteriostatic effects, which are attributed dense particle clusters. facilitates formation regular bone trabeculae. Comparative on osteonecrosis SPEEK-PDA-VEGF highlighted mature trabeculae angiogenic protein CD31 around SPEEK-PDA-VEGF. materials have good activity repair activity. In particular, best effect repair.

Language: Английский

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Divergent Effects of Premineralization and Prevascularization on Osteogenesis and Vascular Integration in Humanized Tissue Engineered Bone Constructs

Published: Jan. 1, 2025

Language: Английский

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The Phase‐Transited Lysozyme Coating Modified Small Intestinal Submucosa Membrane Loaded with Calcium and Zinc Ions for Enhanced Bone Regeneration

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Bone defects caused by severe trauma, tumors, infections and diseases remain a global challenge due to limited natural regeneration capacity of bone tissue in large-scale or complex injuries. Guided (GBR) has emerged as pivotal technique addressing these issues, relying on barrier membranes facilitate osteoprogenitor cell infiltration. Current clinical GBR function solely physical barriers, lacking antibacterial osteoinductive properties, which underscores the need for advanced alternatives. This study focuses resorbable made from small intestinal submucosa (SIS), known biocompatibility but hindered low mechanical strength rapid degradation. In addition, SIS lacks both properties strong osteogenic capabilities. Enhancements involve crosslinking treatment dual incorporation calcium (Ca2+) zinc (Zn2+), address property shortcomings synergistically boost osteoinductivity activating signaling pathways. Additionally, phase-transited lysozyme (PTL) nanofilm enables efficient ion loading controlled release, while offering properties. this study, multifunctional membrane is constructed PTL-ions layers, providing potential solution defects.

Language: Английский

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