Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1313 - 1313

Published: April 21, 2023

Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as material of promise for drug delivery biomedical applications. Different chitin chitosan extraction techniques can produce materials with unique properties, which be further modified to enhance their bioactivities. Chitosan-based systems have been developed various routes administration, including oral, ophthalmic, transdermal, nasal, vaginal, allowing targeted sustained release drugs. Additionally, used in numerous applications, such bone regeneration, cartilage tissue cardiac corneal periodontal wound healing. Moreover, also utilized gene delivery, bioimaging, vaccination, cosmeceutical Modified derivatives improve biocompatibility resulting innovative promising potentials This article summarizes the recent findings on its application science.

Language: Английский

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Recent Advances in Chitosan-Based Applications—A Review

Materials, Journal Year: 2023, Volume and Issue: 16(5), P. 2073 - 2073

Published: March 3, 2023

Chitosan derived from chitin has gathered much interest as a biopolymer due to its known and possible broad applications. Chitin is nitrogen-enriched polymer abundantly present in the exoskeletons of arthropods, cell walls fungi, green algae, microorganisms, radulae beaks molluscs cephalopods, etc. promising candidate for wide variety applications macromolecular structure unique biological physiological properties, including solubility, biocompatibility, biodegradability, reactivity. derivatives have been be applicable medicine, pharmaceuticals, food, cosmetics, agriculture, textile paper industries, energy industry, industrial sustainability. More specifically, their use drug delivery, dentistry, ophthalmology, wound dressing, encapsulation, bioimaging, tissue engineering, food packaging, gelling coating, additives preservatives, active biopolymeric nanofilms, nutraceuticals, skin hair care, preventing abiotic stress flora, increasing water availability plants, controlled release fertilizers, dye-sensitised solar cells, wastewater sludge treatment, metal extraction. The merits demerits associated with chitosan above are elucidated, finally, key challenges future perspectives discussed detail.

Language: Английский

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Natural Fibers Composites: Origin, Importance, Consumption Pattern, and Challenges

Journal of Composites Science, Journal Year: 2023, Volume and Issue: 7(12), P. 506 - 506

Published: Dec. 4, 2023

This comprehensive review explores the multifaceted world of natural fiber applications within domain composite materials. Natural fibers are meticulously examined in detail, considering their diverse origins, which encompass plant-derived (cellulose-based), animal-derived (protein-based), and even mineral-derived variations. conducts a profound analysis, not only scrutinizing chemical compositions, intricate structures, inherent physical properties but also highlighting wide-ranging across various industries. The investigation extends to composites utilizing mineral or polymer matrices, delving into synergistic interplay resulting material properties. Furthermore, this does limit itself intrinsic attributes ventures realm innovative enhancements. exploration encompasses augmentation through integration fibers, including incorporation nano-fillers, offering compelling avenue for further research technological development. In conclusion, synthesizes understanding pivotal role It brings together insights from properties, practical sectors. As final curtain is drawn, discourse transcends present outline trajectories future work dynamic arena composites, shedding light on emerging trends that promise shape course scientific industrial advancements.

Language: Английский

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Recent Applications of Chitosan and Its Derivatives in Antibacterial, Anticancer, Wound Healing, and Tissue Engineering Fields

Polymers, Journal Year: 2024, Volume and Issue: 16(10), P. 1351 - 1351

Published: May 10, 2024

Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse chitosan derivatives antibacterial, anticancer, wound healing, tissue engineering fields. In antibacterial applications, exhibits potent antimicrobial properties by disrupting microbial membranes DNA, making it promising natural preservative agent against bacterial infections. Its role cancer therapy involves development chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays crucial healing promoting cell proliferation, angiogenesis, regulating inflammatory responses. Additionally, serves multifunctional scaffold engineering, facilitating regeneration tissues cartilage, bone, neural adhesion proliferation. The extensive range pharmaceutical sciences is not only highlighted comprehensive scope this review, but establishes fundamental component forthcoming research biomedicine.

Language: Английский

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Harnessing Natural Polymers for Nano-Scaffolds in Bone Tissue Engineering: A Comprehensive Overview of Bone Disease Treatment

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(1), P. 585 - 611

Published: Jan. 5, 2024

Numerous surgeries are carried out to replace tissues that have been harmed by an illness or accident. Due various surgical interventions and the requirement of bone substitutes, emerging field tissue engineering attempts repair damaged with help scaffolds. These scaffolds act as template for regeneration controlling development new cells. For creation functional organs, there three elements play very crucial role: cells, signals achievement these aims, types natural polymers, like chitosan, chitin, cellulose, albumin silk fibroin, used preparation Scaffolds produced from polymers many advantages: they less immunogenic well being biodegradable, biocompatible, non-toxic cost effective. The hierarchal structure bone, microscale nanoscale, is mostly made up organic inorganic components nanohydroxyapatite collagen components. This review paper summarizes knowledge updates information about use scaffolds, their application in recent research trends area (BTE). article extensively explores related analyze advancement nanotechnology treatment bone-related diseases repair.

Language: Английский

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An Overview on the Big Players in Bone Tissue Engineering: Biomaterials, Scaffolds and Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3836 - 3836

Published: March 29, 2024

Presently, millions worldwide suffer from degenerative and inflammatory bone joint issues, comprising roughly half of chronic ailments in those over 50, leading to prolonged discomfort physical limitations. These conditions become more prevalent with age lifestyle factors, escalating due the growing elderly populace. Addressing these challenges often entails surgical interventions utilizing implants or grafts, though treatments may entail complications such as pain tissue death at donor sites for along immune rejection. To surmount challenges, engineering has emerged a promising avenue injury repair reconstruction. It involves use different biomaterials development three-dimensional porous matrices scaffolds, alongside osteoprogenitor cells growth factors stimulate natural regeneration. This review compiles methodologies that can be used develop are important replacement Biomaterials orthopedic implants, several scaffold types production methods, well techniques assess biomaterials’ suitability human use—both laboratory settings within living organisms—are discussed. Even researchers have had some success, there is still room improvements their processing techniques, especially ones make scaffolds mechanically stronger without weakening biological characteristics. Bone therefore area rise bone-related injuries.

Language: Английский

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Bio electrochemical and In-vitro bioactivity evaluation of Araucaria columnaris interceded α-MoO3 nano rods fused chitosan-sodium alginate scaffold for Tissue Engineering Applications

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141384 - 141384

Published: Jan. 1, 2025

Language: Английский

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Long-Term Efficacy of Carboxymethyl-Chitosan in Advanced Knee Osteoarthritis: A Twelve-Month Follow-Up Study on Non-Responders to Hyaluronic Acid

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 270 - 270

Published: Jan. 22, 2025

Background: Knee osteoarthritis (OA) is a prevalent degenerative joint disease characterized by the degeneration of cartilage. OA leads to pain, stiffness, swelling, and decreased mobility, significantly impacting quality life affected people. Advanced-stage often necessitates surgical intervention due poor response conventional treatments, such as intra-articular hyaluronic acid (HA). Carboxymethyl-chitosan (CM-C), an emerging therapeutic agent, has shown potential in reducing inflammation, improving lubrication, enhancing function. This study aimed evaluate long-term efficacy CM-C injections patients with advanced knee osteoarthritis, non-responders HA. Methods: retrospective included 16 (mean age: 79.56 years) Kellgren–Lawrence grade 3–4 treated single injection CM-C. Pain functional outcomes were assessed using Visual Analogue Scale (VAS) Injury Osteoarthritis Outcome Score (KOOS) at baseline (T0), one month (T1), three months (T2), six (T3), twelve (T4). Results: Significant pain reduction was observed early follow up, (VAS: T1 p = 0.0002, T2 0.0265; KOOS Pain: 0.0014). However, partially returned T3 T4. activities daily living (p 0.0005), QoL 0.0396), Sport Free Time 0.0367) subscales showed significant improvement T1, though worsening trends subsequent up raw values suggesting persistent benefits. Strong negative correlations found between VAS various ups. Conclusions: A demonstrated relief for effects may diminish over time, necessitating careful consideration re-treatment strategies or combined therapies.

Language: Английский

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Bacterial Cellulose-Based Polymer Nanocomposites: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(21), P. 4670 - 4670

Published: Nov. 2, 2022

Bacterial cellulose (BC) is currently one of the most popular environmentally friendly materials with unique structural and physicochemical properties for obtaining various functional a wide range applications. In this regard, literature reporting on bacterial nanocellulose has increased exponentially in past decade. Currently, extensive investigations aim at promoting manufacturing BC-based nanocomposites other components such as nanoparticles, polymers, biomolecules, that will enable to develop advanced novel functionalities. However, commercial production limited by high cost low yield BC, lack highly efficient industrial technologies well. Therefore, present review aimed studying current data field BC purpose its further usage obtain polymer nanocomposites. The highlights progress synthesizing their applications biomedical fields, wound healing, drug delivery, tissue engineering. nanocellulose-based biosensors adsorbents were introduced herein.

Language: Английский

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Nanocomposite Bioprinting for Tissue Engineering Applications

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 103 - 103

Published: Jan. 24, 2023

Bioprinting aims to provide new avenues for regenerating damaged human tissues through the controlled printing of live cells and biocompatible materials that can function therapeutically. Polymeric hydrogels are commonly investigated ink 3D 4D bioprinting applications, as they contain intrinsic properties relative those native tissue extracellular matrix be printed produce scaffolds hierarchical organization. The incorporation nanoscale material additives, such nanoparticles, bulk inks, has allowed significant tunability mechanical, biological, structural, physicochemical during after printing. modulatory biological effects nanoparticles bioink additives derive from their shape, size, surface chemistry, concentration, and/or source, making many configurations nanoparticle high interest thoroughly improved design bioactive engineering constructs. This paper review well other additive materials, printable bioinks specifically bone, cartilage, dental, cardiovascular tissues. An overview various classifications will discussed with emphasis on cellular mechanical interactions, formulation methodologies techniques. current advances limitations within field highlighted.

Language: Английский

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