Biphasic drug release from electrospun structures DOI
Jianfeng Zhou, Pu Wang, Deng‐Guang Yu

et al.

Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(5), P. 621 - 640

Published: May 4, 2023

Introduction Biphasic release, as a special drug-modified release profile that combines immediate and sustained allows fast therapeutic action retains blood drug concentration for long periods. Electrospun nanofibers, particularly those with complex nanostructures produced by multi-fluid electrospinning processes, are potential novel biphasic delivery systems (DDSs).Areas covered This review summarizes the most recent developments in related structures. In this review, role of electrospun was comprehensively explored. These include monolithic nanofibers obtained through single-fluid blending electrospinning, core-shell Janus prepared via bifluid three-compartment trifluid nanofibrous assemblies layer-by-layer deposition combined structure nanofiber mats casting films. The strategies mechanisms which structures facilitate were analyzed.Expert opinion can provide many development DDSs. However, issues such scale-up productions nanostructures, vivo verification effects, keeping pace drawing support from state-of-the-art pharmaceutical excipients, combination traditional methods need to be addressed real applications.

Language: Английский

Progress of Electrospun Nanofibrous Carriers for Modifications to Drug Release Profiles DOI Creative Commons
Ying Wang, Deng‐Guang Yu, Yang Liu

et al.

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(4), P. 289 - 289

Published: Dec. 9, 2022

Electrospinning is an advanced technology for the preparation of drug-carrying nanofibers that has demonstrated great advantages in biomedical field. Electrospun nanofiber membranes are widely used field drug administration due to their such as large specific surface area and similarity extracellular matrix. Different electrospinning technologies can be prepare different structures, those with a monolithic structure, core–shell Janus or porous structure. It also possible controlled-release functions, sustained release, delayed biphasic targeted release. This paper elaborates on drug-loaded using various concludes mechanisms behind controlled release drugs.

Language: Английский

Citations

103
The Applications of Ferulic-Acid-Loaded Fibrous Films for Fruit Preservation DOI Open Access
Xinyi Huang,

Wenlai Jiang,

Jianfeng Zhou

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(22), P. 4947 - 4947

Published: Nov. 16, 2022

The aim of this study was to develop a novel ultrathin fibrous membrane with core-sheath structure as an antioxidant food packaging membrane. prepared by coaxial electrospinning, and the release active substances regulated its special structure. Ferulic acid (FA) incorporated into electrospun zein/polyethylene oxide fibers ensure their synergistic properties. We found that had good morphology smooth surface. internal stable, three materials we used were compatible. For different loading positions, it observed core layer ferulic-acid-loaded sustained action, while sheath pre-burst action. Finally, apples selected for using membranes simulate practical applications. effective in reducing water loss apple quality loss, well extending shelf life. According these experiments, FA-loaded zein/PEO electrospinning fiber can be will also undergo more improvements future.

Language: Английский

Citations

100
Processes of Electrospun Polyvinylidene Fluoride-Based Nanofibers, Their Piezoelectric Properties, and Several Fantastic Applications DOI Open Access

Yubin Bai,

Yanan Liu, He Lv

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(20), P. 4311 - 4311

Published: Oct. 13, 2022

Since the third scientific and technological revolution, electronic information technology has developed rapidly, piezoelectric materials that can convert mechanical energy into electrical have become a research hotspot. Among them, polymers are widely used in various fields such as water treatment, biomedicine, flexible sensors due to their good flexibility weak toxicity. However, compared with ceramic materials, properties of poor, so it is very important improve polymers. Electrospinning by adjusting electrospinning parameters control piezoelectrically active phase transition In addition, prepared nanofibrous membrane also substrate for supporting functional particles, which effectively doping particles. This paper reviews electrospun polymer membranes, especially polyvinylidene fluoride (PVDF)-based membranes (NFs). Additionally, this introduces methods increasing from perspective structure species. Finally, applications NFs biology, energy, photocatalysis discussed, future directions development prospected.

Language: Английский

Citations

92
Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance DOI
Jianfeng Zhou, Tao Yi, Zhiyuan Zhang

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2023, Volume and Issue: 6(6)

Published: Oct. 17, 2023

Language: Английский

Citations

80
Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers DOI Open Access
Pu Wang, He Lv,

Xianyang Cao

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 921 - 921

Published: Feb. 12, 2023

Electrospun porous nanofibers have gained a lot of interest recently in various fields because their adjustable structure, high specific surface area, and large number active sites, which can further enhance the performance materials. This paper provides an overview common polymers, preparation, applications electrospun nanofibers. Firstly, polymers commonly used to construct structures main pore-forming methods by electrospinning, namely template method phase separation method, are introduced. Secondly, recent air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound wave absorption, flame retardant, heat insulation reviewed. Finally, challenges possible research directions for future study discussed.

Language: Английский

Citations

76
Piezoelectric Effect Polyvinylidene Fluoride (PVDF): From Energy Harvester to Smart Skin and Electronic Textiles DOI
Zhangbin Feng, Ziquan Zhao, Yanan Liu

et al.

Advanced Materials Technologies, Journal Year: 2023, Volume and Issue: 8(14)

Published: May 5, 2023

Abstract With the great demand for flexible self‐powered sensors and nanogenerators, polyvinylidene fluoride (PVDF) is widely investigated outstanding piezoelectric dielectric constant. In pursuit increasing β content, electrospinning exhibited to be an effective method without external high voltage pooling or mechanical stretching thus considered a cost‐effective simple method, because molecular dipoles in PVDF can aligned during process of with field stretching. The methods improving characteristics are briefly introduced this review, fibers including uniaxial fibers, highly core–shell Janus revealed, research on theoretical modeling carried out efficiency design nanogenerator. Last, studies prospective applications based electrospun its copolymer PVDF‐TrFE, from smart skin, energy harvesters electronic textiles, being conducted.

Language: Английский

Citations

73
Engineered shapes using electrohydrodynamic atomization for an improved drug delivery DOI
Deng‐Guang Yu,

Wenjian Gong,

Jianfeng Zhou

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The shapes of micro‐ and nano‐products have profound influences on their functional performances, which has not received sufficient attention during the past several decades. Electrohydrodynamic atomization (EHDA) techniques, mainly include electrospinning electrospraying, are facile in manipulate products' shapes. In this review, generated using EHDA for modifying drug release profiles reviewed. These linear nanofibers, round micro‐/nano‐particles, beads‐on‐a‐string hybrids. They can be further divided into different kinds sub‐shapes, explored providing desired pulsatile release, sustained biphasic delayed pH‐sensitive release. Additionally, resulted from organizations electrospun nanofibers discussed delivery, inner structures considered together developing novel delivery systems. future, related shape–performance relationships at nanoscale, besides size, structure structure–performance relationships, would play important roles promoting developments field. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies

Language: Английский

Citations

64
Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites DOI Creative Commons
Chen Shu, Jianfeng Zhou,

Boya Fang

et al.

Macromolecular Materials and Engineering, Journal Year: 2023, Volume and Issue: 309(4)

Published: Nov. 23, 2023

Abstract In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by novel spinneret, is homemade conducting processes. The types electrospun nanofibers E1, electrosprayed microparticles E2, core‐shell E3. SEM TEM results indicate that they have anticipated morphologies inner structures. X‐ray diffraction Fourier Transform Infrared verify KET mainly amorphous in all composites due its fine compatibility with HPMC. vitro tests demonstrate rapid release performances has an order E3>E1>E2≫KET powders. mechanisms suggested advantages compared. super performance E3 furnishing attributed synergistic action small size (of shell thickness), high porosity, state drug, solubility nanostructures can support development nano delivery systems (DDSs) through tailoring spatial distribution molecules within products.

Language: Английский

Citations

62
Recent Progress of Electrospun Herbal Medicine Nanofibers DOI Creative Commons
Hang Liu,

Yubin Bai,

Chang Huang

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(1), P. 184 - 184

Published: Jan. 16, 2023

Herbal medicine has a long history of medical efficacy with low toxicity, side effects and good biocompatibility. However, the bioavailability extract raw herbs bioactive compounds is poor because their water solubility. In order to overcome solubility issues, electrospinning technology can offer delivery alternative resolve them. The electrospun fibers have advantages high specific surface area, porosity, excellent mechanical strength flexible structures. At same time, various natural synthetic polymer-bound mimic extracellular matrix applications in different fields. this paper, development polymers used for incorporating herbal into nanofibers are reviewed. Finally, recent progress these biomedical (drug delivery, wound dressing, tissue engineering) food fields along future prospects discussed.

Language: Английский

Citations

59
Unveiling cutting-edge advances in high surface area porous materials for the efficient removal of toxic metal ions from water DOI Creative Commons
Padmaja V. Mane, Richelle M. Rego, Pei Lay Yap

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 146, P. 101314 - 101314

Published: June 3, 2024

This review offers a comprehensive evaluation of an emerging category adsorbing materials known as high surface area (HSAMs) in the realm water remediation. The objective is to shed light on recent advancements HSAMs featuring multiple dimensionalities, addressing their efficacy toxic metal ions from wastewater. spectrum examined this encompasses metal–organic frameworks (MOFs), covalent organic (COFs), carbon-based porous materials, mesoporous silica, polymer-based layered double hydroxides, and aerogels. delves into state-of-the-art design synthetic approaches for these elucidating inherent properties. It particularly emphasizes how combination pore structure contributes effectiveness ions. These possess remarkable attributes, including molecular functionalization versatility, porosity, expansive area, distinctive physicochemical characteristics, well-defined crystal structures, rendering them exceptional adsorbents. While each boasts unique advantages stemming properties, synthesis often entails intricate costly procedures, presenting substantial obstacle commercialization widespread adoption. Finally, underscores existing challenges that must be addressed expedite translation remediation applications promising materials.

Language: Английский

Citations

53