Nanomedicine,
Journal Year:
2024,
Volume and Issue:
19(28), P. 2413 - 2432
Published: Sept. 26, 2024
The
pathological
mechanism
of
scar
is
highly
complex,
encompassing
the
abnormalities
diverse
cytokines,
signaling
pathways
and
regulatory
factors.
To
discover
more
preferable
treatment
options,
a
variety
distinct
approaches
have
been
utilized
clinically.
Nevertheless,
these
treatments
possess
certain
side
effects
are
inclined
to
relapse.
Presently,
remains
clinical
conundrum,
there
an
urgent
demand
for
methods
that
safe,
less
traumatic
lower
recurrence
rates.
New
drug
delivery
systems,
novel
therapeutic
drugs
therapy
strategies
can
enable
permeate
skin
effectively,
decrease
effects,
enhance
efficacy
even
achieve
pain-free
self-administration.
Currently,
nanotechnologies
such
as
nanomicroneedles,
photodynamics
mediated
by
photosensitizers,
bioelectrical
stimulation
3D
printed
dressings
developed
effective
scars.
Additionally,
innovative
nanoscale
fillers,
including
nano-fat
engineered
exosomes,
serve
agents
efficient
intervention
nanomaterials
absorption,
stabilize
safeguard
active
ingredients
drugs,
delay
or
control
release
bioavailability.
This
article
reviews
new
explore
safe
keloid
treatment.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 883 - 899
Published: Jan. 1, 2024
Hypertrophic
scars
and
keloids
are
common
fibroproliferative
diseases
following
injury.Patients
with
pathologic
suffer
from
impaired
quality
of
life
psychological
health
due
to
appearance
disfiguration,
itch,
pain,
movement
disorders.Recently,
the
advancement
hydrogels
in
biomedical
fields
has
brought
a
variety
novel
materials,
methods
therapeutic
targets
for
treating
hypertrophic
keloids,
which
exhibit
broad
prospects.This
review
summarized
current
research
on
loaded
components
used
preventing
keloids.These
attenuate
keloid
scar
formation
progression
by
loading
organic
chemicals,
drugs,
or
bioactive
molecules
(such
as
growth
factors,
genes,
proteins/peptides,
stem
cells/exosomes).Among
them,
smart
(a
very
promising
method
many
types
components)
currently
favoured
researchers.In
addition,
combining
therapy
laser
radiation
therapy,
etc.)
could
improve
treatment
keloids.Then,
difficulties
limitations
possible
suggestions
improvement
listed.Moreover,
we
also
propose
strategies
facilitating
construction
target
multifunctional
future.
Bioengineering,
Journal Year:
2023,
Volume and Issue:
10(10), P. 1127 - 1127
Published: Sept. 25, 2023
Quercetin
is
a
polyphenol
of
the
flavonoid
class
secondary
metabolites
that
widely
distributed
in
plant
kingdom.
has
been
found
to
exhibit
potent
bioactivity
areas
wound
healing,
neuroprotection,
and
anti-aging
research.
Naturally
highly
glycosylated
forms,
aglycone
quercetin
low
solubility
aqueous
environments,
which
heavily
limited
its
clinical
applications.
To
improve
stability
bioavailability
quercetin,
efforts
have
made
chemically
modify
related
flavonoids
so
as
while
retaining
bioactivity.
In
this
review,
we
provide
an
updated
overview
biological
properties
proposed
mechanisms
actions
context
healing
aging.
We
also
description
recent
developments
synthetic
approaches
analogs
for
therapeutic
Further
research
these
expected
enable
translational
applications
ocular
tissue
repair.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Chronic
skin
wounds
are
a
leading
cause
of
hospital
admissions
and
reduced
life
expectancy
among
older
people
individuals
with
diabetes.
Delayed
wound
healing
is
often
attributed
to
series
cellular
abnormalities.
Matrine,
well-studied
component
found
in
Polymers,
Journal Year:
2025,
Volume and Issue:
17(1), P. 108 - 108
Published: Jan. 2, 2025
Disruption
of
the
molecular
pathways
during
physiological
wound
healing
can
lead
to
raised
scar
formation,
characterized
by
rigid,
thick
tissue
with
associated
symptoms
pain
and
pruritus.
A
key
mechanical
factor
in
development
is
excessive
tension
at
site.
Recently,
microneedles
(MNs)
have
emerged
as
promising
tools
for
management
they
engage
provide
them
off-loading
from
both
internal
external
sources.
This
review
explores
mechanisms
which
physical
intervention
drug-free
MNs
alleviates
on
fibroblasts
within
tissue,
thereby
promoting
remodeling
reducing
severity.
Additionally,
role
an
efficient
cargo
delivery
system
controlled
sustained
release
a
wide
range
therapeutic
agents
into
highlighted.
By
penetrating
facilitate
localized
drug
administration
modulate
inflammation
fibroblastic
cell
growth.
Finally,
remaining
challenges
future
perspective
field
been
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
379, P. 1 - 13
Published: Jan. 7, 2025
Keloids
are
pathological
scars
characterized
by
excessive
fibroblast
proliferation,
abnormal
collagen
deposition,
and
chronic
inflammation,
which
often
result
in
high
recurrence
rates
limited
treatment
success.
Targeting
BACH1
with
gene
therapy
has
shown
promise
regulating
activity
reducing
inflammation.
However,
effective
delivery
systems
for
targeted
keloids
remain
a
major
challenge.
Here,
we
develop
novel
nanocarrier
platform
based
on
orthogonal
upconversion
nanoparticles
(OUNCs)
to
achieve
spatiotemporal
silencing
of
combined
photodynamic
(PDT).
The
OUNCs
composed
(UCNPs),
photosensitizer
(Rose
Bengal),
ROS-sensitive
diselenide
bonds
(SeSe),
therapeutic
siBACH1,
an
active
targeting
moiety
(hyaluronic
acid)
specifically
target
keloid
fibroblasts
(KFs).
We
demonstrate
that
the
can
effectively
induce
KFs
apoptosis,
inhibit
reduce
M2
macrophages
recruitment
modulating
Rap1/MEK/ERK
signaling
pathway.
Our
study
represents
breakthrough
precision
keloids,
providing
promising
integrates
siBACH1-based
NIR
light-triggered
PDT.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
Dermatological
diseases
represent
one
of
the
most
prevalent
health
concerns
globally,
with
associated
care
and
treatment
costs
having
consistently
increased
over
past
decade.
Current
therapeutic
modalities,
including
topical
medications,
oral
pharmaceuticals,
physical
therapies,
frequently
face
challenges
such
as
inadequate
drug
absorption
substantial
adverse
effects.
Microneedles,
recognized
minimally
invasive
delivery
systems,
effectively
penetrate
cutaneous
barrier
to
enhance
permeability
efficacy.
Polyphenols—abundant
in
botanical
marine
sources—demonstrate
diverse
pharmacological
properties
encompassing
anti‐inflammatory
antioxidant
activities.
The
integration
polyphenols
microneedle
technology
has
emerged
a
promising
strategy
for
dermatological
conditions,
demonstrating
significant
clinical
potential.
This
review
examines
multifunctional
capabilities
polyphenol‐incorporated
microneedles
elucidates
their
mechanisms
action
managing
disorders.
Furthermore,
it
synthesizes
recent
progress
polyphenol‐based
applications
various
pathologies,
acne
vulgaris,
psoriasis,
atopic
dermatitis.
Finally,
current
is
discussed
proposed
future
research
directions
optimizing
polyphenol
systems
therapeutics.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 3, 2023
Wound
healing
is
a
dynamic
and
complex
restorative
process,
traditional
dressings
reduce
their
therapeutic
effectiveness
due
to
the
accumulation
of
drugs
in
cuticle.
As
novel
drug
delivery
system,
microneedles
(MNs)
can
overcome
defect
deliver
deeper
layers
skin.
core
microneedle
loaded
exert
significant
influence
on
efficacy
MNs.
Metallic
elements
herbal
compounds
have
been
widely
used
wound
treatment
for
ability
accelerate
process.
primarily
serve
as
antimicrobial
agents
facilitate
enhancement
cell
proliferation.
Whereas
various
act
different
targets
inflammatory,
proliferative,
remodeling
phases
healing.
The
interaction
between
two
forms
nanoparticles
(NPs)
metal-organic
frameworks
(MOFs),
reducing
toxicity
metallic
increasing
effect.
This
article
summarizes
recent
trends
development
MNs
made
healing,
describes
advantages
treatment,
provides
reference
future
