International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14709 - 14709
Published: Sept. 28, 2023
The
development
of
brain
in
vitro
models
requires
the
application
novel
biocompatible
materials
and
biopolymers
as
scaffolds
for
controllable
effective
cell
growth
functioning.
"ideal"
model
should
demonstrate
principal
features
plasticity
like
synaptic
transmission
remodeling,
neurogenesis
angiogenesis,
changes
metabolism
associated
with
establishment
new
intercellular
connections.
Therefore,
extracellular
that
are
helpful
maintenance
local
microenvironments
supporting
mechanisms
critical
importance.
In
this
review,
we
will
focus
on
some
carbohydrate
metabolites-lactate,
pyruvate,
oxaloacetate,
malate-that
greatly
contribute
to
regulation
cell-to-cell
communications
metabolic
cells
resorbable
may
reproduce
microenvironment
enriched
particular
metabolites.
Polymers for Advanced Technologies,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Oct. 9, 2023
Abstract
Polysaccharides
are
a
class
of
natural
biopolymers
that
have
attracted
significant
attention
due
to
their
unique
properties,
which
make
them
attractive
for
use
in
wide
range
applications.
These
an
important
role
our
daily
life,
and
designing
biomaterials
biomedical
applications
requires
careful
consideration
factors
such
as
biocompatibility,
biodegradability,
renewability,
affordability,
availability,
all
can
be
achieved
with
polysaccharides.
This
review
paper
focuses
on
the
polysaccharides
provides
in‐depth
analysis
potential
arabinoxylan,
type
hemicellulose,
various
fields,
including
drug
delivery,
infection
control,
tissue
engineering,
wound
healing,
others.
Arabinoxylan,
is
derived
from
plants,
most
abundant
hemicellulose
has
diverse
catalyst
its
renewable
nature.
Polysaccharide‐based
covers,
delivery
systems,
food
preservation,
biocomposite
films,
making
emerging
excipient
pharmaceutical
research.
highlights
polysaccharide‐based
science
suggests
continued
research
development
will
lead
broader
more
innovative
field.
The
significantly
advance
healthcare
improve
patient
outcomes.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Feb. 3, 2023
Slaughterhouses
produce
large
quantities
of
biological
waste,
and
most
these
materials
are
underutilized.
In
many
published
reports,
the
possibility
repurposing
this
form
waste
to
create
biomaterials,
fertilizers,
biogas,
feeds
has
been
discussed.
However,
employment
particular
offal
wastes
in
xenotransplantation
yet
be
extensively
uncovered.
Overall,
viable
transplantable
tissues
organs
scarce,
developing
bioartificial
components
using
such
discarded
may
help
increase
their
supply.
This
perspective
manuscript
explores
viability
sustainability
readily
available
easily
sourced
slaughterhouse
as
blood
vessels,
eyes,
kidneys,
tracheas,
starting
derived
from
decellularization
technologies.
The
also
examines
innovative
use
animal
stem
cells
excreta
a
tissue/organ
platform
that
can
translated
humans.
Institutional
governmental
regulatory
approaches
will
outlined
support
endeavor.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: March 10, 2023
Acute
kidney
injury
(AKI)
relates
to
an
abrupt
reduction
in
renal
function
resulting
from
numerous
conditions.
Morbidity,
mortality,
and
treatment
costs
related
AKI
are
relatively
high.
This
condition
is
strongly
associated
with
damage
proximal
tubule
cells
(PTCs),
generating
distinct
patterns
of
transcriptional
epigenetic
alterations
that
result
structural
changes
the
nuclei
this
epithelium.
To
date,
AKI-related
nuclear
chromatin
redistribution
PTCs
poorly
understood,
it
unclear
whether
PTC
can
be
detected
using
conventional
microscopy
during
mild
AKI,
which
progress
more
debilitating
forms
injury.
In
recent
years,
gray
level
co-occurrence
matrix
(GLCM)
analysis
discrete
wavelet
transform
(DWT)
have
emerged
as
potentially
valuable
methods
for
identifying
architecture
not
visible
histopathological
exam.
Here
we
present
findings
indicating
GLCM
DWT
successfully
used
nephrology
detect
subtle
morphological
tissue
demonstrated
rodents
by
inducing
a
form
through
ischemia-reperfusion
Our
results
show
ischemic
local
textural
homogeneity
quantified
increase
heterogeneity
indirectly
assessed
energy
coefficients.
rodent
model
allowed
us
significant
nuclei,
indicators
Virtual and Physical Prototyping,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Aug. 30, 2024
Advanced
three-dimensional
(3D)
bioprinting
technology
enables
the
precise
production
of
complex
vascular
structures
and
biomimetic
models,
driving
advancements
in
tissue
engineering
disease
mechanism
research.
At
core
this
is
smart
bioink,
which
suitable
for
fabricating
models
that
can
be
vascularised
to
meet
property
requirements
various
tissues.
Examples
bioinks
include
decellularized
extracellular
matrix
(dECM),
photocrosslinkable,
reversible,
microgel-based
biphasic
(MB)
bioinks,
whose
mechanical
properties
tuned
through
external
stimuli.
This
tuning
helps
generate
high-resolution
complex-shaped
networks
essential
cell
survival
functional
maturation.
review
explores
advanced
3D
strategies
using
spatially
controlled
perfusable
vitro
emphasising
reconstruction
within
bioprinted
models.
It
also
discusses
challenges
future
prospects,
suggesting
could
serve
as
alternatives
traditional
animal
modelling
drug
screening.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: May 26, 2023
Decellularized
corneas
offer
a
promising
and
sustainable
source
of
replacement
grafts,
mimicking
native
tissue
reducing
the
risk
immune
rejection
post-transplantation.
Despite
great
success
in
achieving
acellular
scaffolds,
little
consensus
exists
regarding
quality
decellularized
extracellular
matrix.
Metrics
used
to
evaluate
matrix
performance
are
study-specific,
subjective,
semi-quantitative.
Thus,
this
work
focused
on
developing
computational
method
examine
effectiveness
corneal
decellularization.
We
combined
conventional
semi-quantitative
histological
assessments
automated
scaffold
evaluations
based
textual
image
analyses
assess
decellularization
efficiency.
Our
study
highlights
that
it
is
possible
develop
contemporary
machine
learning
(ML)
models
random
forests
support
vector
algorithms,
which
can
identify
regions
interest
acellularized
stromal
with
relatively
high
accuracy.
These
results
provide
platform
for
biosensing
systems
evaluating
subtle
morphological
changes
crucial
assessing
their
functionality.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
31, P. 590 - 602
Published: Oct. 4, 2023
To
date,
several
off-the-shelf
products
such
as
artificial
blood
vessel
grafts
have
been
reported
and
clinically
tested
for
small
diameter
(SDV)
replacement.
However,
conventional
lack
endothelium
and,
thus,
are
not
ideal
SDV
transplantation
they
can
cause
thrombosis.
In
addition,
a
successful
graft
must
sufficient
mechanical
properties
to
withstand
various
external
stresses.
Here,
we
developed
spontaneous
cellular
assembly
(S-SDV)
that
develops
without
additional
intervention.
By
improving
the
dragging
3D
printing
technique,
constructs
with
free-form,
multilayers
controllable
pore
size
be
fabricated
at
once.
Then,
The
S-SDV
filled
in
natural
polymer
bioink
containing
human
umbilical
vein
endothelial
cells
(HUVECs)
aorta
smooth
muscle
(HAoSMCs).
induced
by
migration
self-assembly
of
through
pores
construct.
antiplatelet
adhesion
formed
on
luminal
surface
was
also
confirmed.
this
had
(burst
pressure,
suture
retention,
leakage
test)
transplantation.
We
believe
could
address
challenges
SDVs:
notably,
formation
properties.
particular,
designed
simply
free-form
structure
desired
size.
Since
is
easy
even
constructs,
it
expected
useful
vascular
structures
branch
or
curve
shapes,
other
tubular
tissues
esophagus.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: April 25, 2023
Corneal
disease
is
a
leading
cause
of
blindness
globally
that
stems
from
various
etiologies.
High-throughput
platforms
can
generate
substantial
quantities
corneal
grafts
will
be
invaluable
in
addressing
the
existing
global
demand
for
keratoplasty.
Slaughterhouses
underutilized
biological
waste
repurposed
to
reduce
current
environmentally
unfriendly
practices.
Such
efforts
support
sustainability
simultaneously
drive
development
bioartificial
keratoprostheses.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 20, 2023
Corneal
opacity
is
a
leading
cause
of
vision
impairment
and
suffering
worldwide.
Transplantation
can
effectively
restore
reduce
chronic
discomfort.
However,
there
considerable
shortage
viable
corneal
graft
tissues.
Tissue
engineering
may
address
this
issue
by
advancing
xeno-keratoplasty
as
alternative
to
conventional
keratoplasty.
In
particular,
livestock
decellularization
strategies
offer
the
potential
generate
bioartificial
ocular
prosthetics
in
sufficient
supply
match
existing
projected
needs.
To
end,
we
have
examined
best
practices
characterizations
that
supported
current
state-of-the-art
driving
preclinical
clinical
applications.
Identifying
challenges
delimit
activities
supplement
donor
pool
derived
from
acellular
scaffolds
allowed
us
hypothesize
model
for
keratoprosthesis
applications
combining
3D
printing
decellularization.
