ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(27), P. 29139 - 29158
Published: June 24, 2024
Hydrogel
encapsulation
is
a
promising
carrier
for
cell
and
drug
delivery
due
to
its
ability
protect
the
encapsulated
entities
from
harsh
physiological
conditions
enhance
their
therapeutic
efficacy
bioavailability.
However,
there
not
yet
consensus
on
optimal
hydrogel
type,
method,
clinical
application.
Therefore,
systematic
review
of
techniques
potential
application
needed
provide
comprehensive
up-to-date
overview.
In
this
review,
we
searched
electronic
databases
articles
published
between
2008
2023
that
described
cells
or
molecules
within
hydrogels.
Herein,
identified
9
relevant
studies
met
inclusion
exclusion
criteria
our
study.
Our
analysis
revealed
physicochemical
properties
hydrogel,
such
as
porosity,
swelling
behavior,
degradation
rate,
play
critical
role
in
molecules.
Furthermore,
including
physical,
chemical,
biological
methods,
can
affect
entities'
stability,
bioavailability,
efficacy.
Challenges
include
poor
control
over
release
entities,
limited
shelf
life,
immune
responses.
Future
directions
development
novel
methods
integration
with
other
technologies,
3D
printing
gene
editing.
conclusion,
useful
researchers,
clinicians,
policymakers
who
are
interested
field
regenerative
medicine
serve
guide
future
technologies
be
applied
into
practice.
Livers,
Journal Year:
2023,
Volume and Issue:
3(2), P. 161 - 189
Published: March 27, 2023
More
than
90%
of
all
liver
malignancies
are
hepatocellular
carcinomas
(HCCs),
for
which
chemotherapy
and
immunotherapy
the
ideal
therapeutic
choices.
Hepatocellular
carcinoma
is
descended
from
other
diseases,
such
as
viral
hepatitis,
alcoholism,
metabolic
syndrome.
Normal
cells
tissues
may
suffer
damage
common
forms
chemotherapy.
In
contrast
to
systemic
chemotherapy,
localized
can
reduce
side
effects
by
delivering
a
steady
stream
chemotherapeutic
drugs
directly
tumor
site.
This
highlights
significance
controlled-release
biodegradable
hydrogels
drug
delivery
methods
chemotherapeutics.
review
discusses
using
systems
HCC
covers
thermosensitive,
pH-sensitive,
photosensitive,
dual-sensitive,
glutathione-responsive
hydrogels.
Compared
conventional
hydrogel-based
more
effective
in
treating
cancer.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(27), P. 29139 - 29158
Published: June 24, 2024
Hydrogel
encapsulation
is
a
promising
carrier
for
cell
and
drug
delivery
due
to
its
ability
protect
the
encapsulated
entities
from
harsh
physiological
conditions
enhance
their
therapeutic
efficacy
bioavailability.
However,
there
not
yet
consensus
on
optimal
hydrogel
type,
method,
clinical
application.
Therefore,
systematic
review
of
techniques
potential
application
needed
provide
comprehensive
up-to-date
overview.
In
this
review,
we
searched
electronic
databases
articles
published
between
2008
2023
that
described
cells
or
molecules
within
hydrogels.
Herein,
identified
9
relevant
studies
met
inclusion
exclusion
criteria
our
study.
Our
analysis
revealed
physicochemical
properties
hydrogel,
such
as
porosity,
swelling
behavior,
degradation
rate,
play
critical
role
in
molecules.
Furthermore,
including
physical,
chemical,
biological
methods,
can
affect
entities'
stability,
bioavailability,
efficacy.
Challenges
include
poor
control
over
release
entities,
limited
shelf
life,
immune
responses.
Future
directions
development
novel
methods
integration
with
other
technologies,
3D
printing
gene
editing.
conclusion,
useful
researchers,
clinicians,
policymakers
who
are
interested
field
regenerative
medicine
serve
guide
future
technologies
be
applied
into
practice.
