Functionalization of Collagen Fiber with Nano-Islands of Silver Via Atomic Layer Deposition Promotes Bone Healing DOI

Sarah Hashemi Astaneh,

Leonardo Pérez Faverani, Harshdeep Bhatia

et al.

Published: Jan. 1, 2023

Modern techniques of thin film deposition (e.g., atomic layer (ALD)) have paved the way for modification surface target substrates with films, nanoparticles, or other types nanomaterials. This novel can improve properties base material and has capability to add/enhance specific through addition functionalized groups surface.In this study, ALD silver was carried out on commercially available collagen membrane bioactivity. Two different sample were studied: pristine silver-coated via (Ag/Collagen). Chemical morphological changes investigated X-ray photoelectron spectroscopy scanning electron microscopy bioactivity studied in vivo.Nano-islands obtained fibrils an average diameter ~16 nm. Comparison gingival cells cultured collagen, demonstrated that attained nanoparticle size concentration are below toxicity level oral environment. In vivo assessment showed biocompatibility Collagen-1300Ag, greater new bone formation. be used surgeries as grafting agent osteopromotive properties.

Language: Английский

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications DOI Creative Commons
Siriporn Taokaew, Worasak Kaewkong, Worawut Kriangkrai

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(4), P. 277 - 277

Published: March 27, 2023

Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability encapsulate, carry, release drug, biocompatibility, biodegradability, non-immunogenicity. In this review, advanced functions of are summarized, with emphasis on fabrications resultant reported literature from recent decade. progress applications drug delivery, tissue engineering, disease treatments, biosensors reviewed. Current challenges future development direction prospected.

Language: Английский

Citations

51

Marine-Derived Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Compounds DOI Open Access

Fabrizia Sepe,

Anna Valentino, Loredana Marcolongo

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 764 - 764

Published: Jan. 17, 2025

Marine polysaccharide hydrogels have emerged as an innovative platform for regulating the in vivo release of natural bioactive compounds medical purposes. These hydrogels, which exceptional biocompatibility, biodegradability, and high water absorption capacity, create effective matrices encapsulating different molecules. In addition, by modifying physical chemical properties marine including cross-linking density, swelling behavior, response to external stimuli like pH, temperature, or ionic strength, profile encapsulated is strictly regulated, thus maximizing therapeutic efficacy minimizing side effects. Finally, using naturally sourced polysaccharides hydrogel formulations, sustainability promoted reducing dependence on synthetic polymers, meeting growing demand eco-friendly materials. This review analyzes interaction between offers examples how molecules can be encapsulated, released, stabilized.

Language: Английский

Citations

2

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives DOI Open Access
Indra Jaya Budiarso, Novi Dwi Widya Rini, Annisa Tsalsabila

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(6), P. 3084 - 3115

Published: May 13, 2023

Over the past decade, smart and functional biomaterials have escalated as one of most rapidly emerging fields in life sciences because performance could be improved by careful consideration their interaction response with living systems. Thus, chitosan play a crucial role this frontier field it possesses many beneficial properties, especially biomedical such excellent biodegradability, hemostatic antibacterial activity, antioxidant biocompatibility, low toxicity. Furthermore, is versatile biopolymer due to its polycationic nature reactive groups that allow polymer form interesting structures or modified various ways suit targeted applications. In review, we provide an up-to-date development chitosan-based nanoparticles, hydrogels, nanofibers, films, well application field. This review also highlights several strategies enhance biomaterial for fast growing applications drug delivery systems, bone scaffolds, wound healing, dentistry.

Language: Английский

Citations

38

Preliminary study on the preparation of antler powder/chitosan/β-glycerophosphate sodium/polyvinyl alcohol porous hydrogel scaffolds and their osteogenic effects DOI Creative Commons

Kudelaiti Abudukelimu,

Aikepaer Aierken,

Ailifeire Tuerxuntayi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: June 26, 2024

Introduction: The production of bone-like structural scaffolds through bone tissue engineering technology is a promising method for regeneration to repair defects. Deer antler, an easily harvested and abundantly sourced initial structure, resembles the composition structure human cancellous can serve as new material allogeneic transplantation. Methods: This study involved preparation characterization antler powder/chitosan/β-glycerophosphate sodium/polyvinyl alcohol (AP/CS/β-GP/PVA) porous hydrogel verify their properties osteogenic mechanisms. microstructure, hydrophilicity, mechanical were studied using Scanning Electron Microscopy (SEM), contact angle measurement, universal testing machine. interactions between various components investigated Fourier-Transform Infrared Spectroscopy (FTIR). Biocompatibility, properties, expression osteogenesis-related proteins evaluated Cell Counting Kit-8 (CCK-8) assays, alkaline phosphatase staining, Alizarin Red live/dead cell Western blot analysis. Results: results showed that content deer powder increased, both hydrophilicity scaffold materials improved, while porosity slightly decreased with increase in content. culture experiments demonstrated higher proportion beneficial proliferation differentiation mouse pre-osteoblast (MC3T3-E1) cells, containing 10% 8% showing best effects. upregulation RUNX2, OCN, OSX, OPN protein may promote differentiation. Discussion: Therefore, AP/CS/β-GP/PVA have potential become biomaterial engineering.

Language: Английский

Citations

4

Integrated GelMA and liposome composite hydrogel with effective coupling of angiogenesis and osteogenesis for promoting bone regeneration DOI Creative Commons

Yuanchen Zhu,

Qi Cheng, Chengyuan Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139835 - 139835

Published: Jan. 15, 2025

Language: Английский

Citations

0

Functionalization of collagen fiber with nano-islands of Silver via atomic layer deposition to promote bone healing DOI Creative Commons

Sarah Hashemi Astaneh,

Leonardo Pérez Faverani, Harshdeep Bhatia

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e42177 - e42177

Published: Jan. 23, 2025

Modern techniques of thin film deposition (e.g., atomic layer [ALD]) have paved the way for modification surface target substrates with films, nanoparticles, or other types nanomaterials. This novel can improve base material's properties and enhance specific through adding functionalized groups to surface. In this study, ALD silver was conducted on commercially available Type I collagen membrane its bioactivity promote bone healing. Two different sample were studied: pristine silver-coated via (Ag/Collagen). Chemical morphological changes investigated X-ray photoelectron spectroscopy scanning electron microscopy studied in vitro vivo. Nano-islands obtained fibrils an average diameter ∼16 nm. Comparison gingival cells cultured collagen, demonstrated that attained nanoparticle size concentration are below toxicity level silver. vivo assessment rat model showed biocompatibility Ag/Collagen, greater new formation compared control. solvent-free method be used functionalize sensitive materials surgeries as grafting agents osteopromotive without any adverse effects cellular environment.

Language: Английский

Citations

0

Gels as Promising Delivery Systems: Physicochemical Property Characterization and Recent Applications DOI Creative Commons
Enzhao Wang,

Zhaoying Qi,

Yu Cao

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 249 - 249

Published: Feb. 14, 2025

Gels constitute a versatile class of materials with considerable potential for applications in both technical and medical domains. Physicochemical property characterization is critical evaluation method gels. Common techniques include pH measurement, structural analysis, mechanical assessment, rheological phase transition studies, among others. While numerous research articles report results, few reviews comprehensively summarize the appropriate numerical ranges these properties. This lack standardization complicates harmonized methods hinders direct comparisons between different To address this gap, it essential to systematically investigate analyze data from extensive body literature on In review, we provide comprehensive summary general present detailed analysis gel support future promote standardized protocols.

Language: Английский

Citations

0

Hydrogel-Based Scaffolds: Advancing Bone Regeneration Through Tissue Engineering DOI Creative Commons

Jalima Quintero,

Rosalío Ramos‐Payán, José Geovanni Romero-Quintana

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 175 - 175

Published: Feb. 27, 2025

Bone tissue engineering has emerged as a promising approach to addressing the limitations of traditional bone grafts for repairing defects. This regenerative medicine strategy leverages biomaterials, growth factors, and cells create favorable environment regeneration, mimicking body’s natural healing process. Among various biomaterials explored, hydrogels (HGs), class three-dimensional, hydrophilic polymer networks, have gained significant attention scaffolds engineering. Thus, this review aimed investigate potential synthetic HGs, molecules used its functionalization, enhanced applications. HGs offer several advantages such scaffolds, including biocompatibility, biodegradability, tunable mechanical properties, ability encapsulate deliver bioactive molecules. These properties make them ideal candidates supporting cell attachment, proliferation, differentiation, ultimately guiding formation new tissue. The design optimization HG-based involve adapting their composition, structure, meet specific requirements regeneration. Current research focuses on incorporating molecules, factors cytokines, into HG further enhance osteoinductive osteoconductive properties. Additionally, strategies improve strength degradation kinetics are being explored ensure long-term stability support formation. development advanced holds great revolutionizing providing effective treatment options patients with

Language: Английский

Citations

0

Toward bioactive calcium carbonate and hydroxyapatite-based coatings via plasma electrolytic oxidation – A review of challenges and current state-of-the-art DOI

Vladlens Grebņevs,

Artūrs Vīksna, Wojciech Simka

et al.

Surface and Coatings Technology, Journal Year: 2025, Volume and Issue: 506, P. 132135 - 132135

Published: April 10, 2025

Language: Английский

Citations

0

Printing β-TCP-laden GelMA/Alginate Interpenetrating-Polymer-Network Biomaterial Inks for Bone Tissue Engineering DOI
Joyce Rodrigues de Souza, Maedeh Rahimnejad, Igor Paulino Mendes Soares

et al.

Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00413 - e00413

Published: April 1, 2025

Language: Английский

Citations

0