Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 22, 2025
Single-functional
wound
dressings
provide
limited
therapeutic
benefits
for
chronic
healing.
Effective
care
wounds
requires
a
multifunction
that
integrates
exudate
management,
treatment,
and
continuous
monitoring.
Here,
we
introduce
an
integrated
Janus
bioelectronic
bandage
designed
to
achieve
self-pumping
management
via
electrospinning
dressing
with
opposite
wettability,
antibacterial
properties
through
silver
nanoparticles
(AgNPs),
the
monitoring
of
multiplex
biomarkers
in
electrochemical
sensors
positioned
on
drainage
side.
The
limits
detection
(LOD)
are
0.15
mM
glucose,
6.85
μM
UA,
60.76
mV/decade
pH
(4–8),
respectively.
We
demonstrated
mice
full-thickness
models
this
effectively
promoted
healing,
achieving
closure
rate
90.35%
day
14,
monitored
dynamic
changes
three
within
situ
over
period
3
days.
Gels,
Journal Year:
2025,
Volume and Issue:
11(1), P. 38 - 38
Published: Jan. 4, 2025
The
skin
serves
as
a
critical
barrier
against
external
pathogens,
and
its
wound
healing
is
complex
biological
process
that
requires
careful
management
to
ensure
optimal
tissue
regeneration.
Hydrogels,
class
of
hydrophilic
polymers,
have
emerged
promising
materials
for
dressings
due
their
biocompatibility,
biodegradability,
ability
create
moist
environment
conducive
cell
proliferation
migration.
In
this
research,
hydrogel
dressing
containing
cefdinir
(Cef)
was
made
from
combination
carboxymethyl
cellulose
(CMC)
gelatin
(Gel)
by
physical
crosslinking
method,
physicochemical,
mechanical,
properties
were
investigated.
Results
show
the
addition
Cef
does
not
cause
significant
change
in
morphology
or
tensile
strength
dressing.
swelling
degradation
rate
slightly
increased
presence
Cef.
enhanced
antibacterial
effects
up
2.5-fold
P.
aeruginosa
(35
mm),
S.
aureus
(36
pyogenes
mm).
results
cytotoxicity
test
showed
absence
both
drug-containing
drug-free
dressings,
well
survival
over
75%
cells
after
48
h.
accelerates
formation
epidermis
layer
production
fibroblast
cells,
result,
process.
percentage
on
ninth
day
treatment
an
untreated
30%,
while
40%
with
without
medicine
60%
medicine,
fifteenth
treatment,
treated
had
more
than
85%
healing.
As
it
possible
use
CMC/Gel
polymeric
healing,
according
desired
physicochemical
biocompatibility.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 22, 2025
Single-functional
wound
dressings
provide
limited
therapeutic
benefits
for
chronic
healing.
Effective
care
wounds
requires
a
multifunction
that
integrates
exudate
management,
treatment,
and
continuous
monitoring.
Here,
we
introduce
an
integrated
Janus
bioelectronic
bandage
designed
to
achieve
self-pumping
management
via
electrospinning
dressing
with
opposite
wettability,
antibacterial
properties
through
silver
nanoparticles
(AgNPs),
the
monitoring
of
multiplex
biomarkers
in
electrochemical
sensors
positioned
on
drainage
side.
The
limits
detection
(LOD)
are
0.15
mM
glucose,
6.85
μM
UA,
60.76
mV/decade
pH
(4–8),
respectively.
We
demonstrated
mice
full-thickness
models
this
effectively
promoted
healing,
achieving
closure
rate
90.35%
day
14,
monitored
dynamic
changes
three
within
situ
over
period
3
days.
