Resorbable conductive materials for optimally interfacing medical devices with the living DOI Creative Commons
Marta Sacchi, Fabien Sauter-Starace, Pascal Mailley

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 21, 2024

Implantable and wearable bioelectronic systems are arising growing interest in the medical field. Linking microelectronic (electronic conductivity) biological (ionic worlds, biocompatible conductive materials at electrode/tissue interface key components these systems. We herein focus more particularly on resorbable systems, which can safely degrade environment once they have completed their purpose, namely, stimulating or sensing activity tissues. Resorbable also explored fields of tissue engineering 3D cell culture. After a short description polymer-based substrates scaffolds, electrical conductors, we review how be combined to design materials. Although still emerging, various biomedical applications already taking shape that profoundly modify post-operative wound healing follow-up. Future challenges perspectives field proposed.

Language: Английский

Biocompatible, injectable and self-healable MOF-based anti-freezing eutectogels for higher encapsulation and sustained release of the anticancer drug curcumin DOI Creative Commons
Nildhara Parsana, Hiral Ukani,

Dharmveer Singh Chauhan

et al.

RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: 1(2), P. 317 - 332

Published: Jan. 1, 2024

A MOF based eutectogel with antibacterial and antioxidant attributes, along hemocompatibility, is used for the encapsulation sustained release of curcumin.

Language: Английский

Citations

10

Enhanced healing of burn wounds by dressings with alginate: An updated systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Jiaqi Lou,

Ziyi Xiang,

Xiaoyu Zhu

et al.

Regenesis repair rehabilitation., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2

Multifunctional hyaluronic acid-based biomimetic/pH-responsive hybrid nanostructured lipid carriers for treating bacterial sepsis DOI Creative Commons
Eman Elhassan, Calvin A. Omolo, Mohammed A. Gafar

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: Feb. 11, 2025

Abstract Introduction The application of biomimetic and stimuli-responsive nanocarriers displays considerable promise in improving the management bacterial sepsis overcoming antimicrobial resistance. Therefore, study aimed to synthesize a novel hyaluronic acid-lysine conjugate (HA-Lys) utilize attributes synthesized HA-Lys with Tocopherol succinate (TS) Oleylamine (OLA) formulation multifunctional pH-responsive HNLCs loaded vancomycin (VCM-HNLCs), combat sepsis. Methods A was characterized using FTIR 1 H NMR spectroscopy. Vancomycin-loaded hybrid nanosystems (VCM-HNLCs) were prepared through hot homogenization ultrasonication evaluated for particle size, polydispersity index (PDI), zeta potential (ZP), encapsulation efficiency (EE%). In vitro biocompatibility assessed via MTT assay red blood cell hemolysis test. binding affinity TLR2 TLR4 measured microscale thermophoresis (MST). Drug release dialysis bag method. Antimicrobial activity against MRSA efflux pump inhibition also determined. Efficacy demonstrated an MRSA-induced mice model. Results VCM-HNLCs, produced ultrasonication, exhibited size (PS), (EE%) 110.77 ± 1.692 nm, 0.113 0.022, − 2.92 0.210 mV, 76.27 1.200%, respectively. , proven by cytotoxicity studies. VCM-HNLCs targetability human Toll-like receptors (TLR 2 4) as validated showed twofold reduction MIC values at physiological pH compared bare VCM S. aureus 48 h. While 6.0, reduced fourfold first 24 h eightfold subsequent 72 tested strains. Furthermore, inhibitory effects pumps, reactive oxygen species (ROS), lipopolysaccharide (LPS)-induced hyperinflammation. model, superior efficacy free VCM, significantly eliminated bacteria improved survival rates. Conclusions Overall, these results highlight resistance (AMR) enhance outcomes. Graphical

Language: Английский

Citations

2

Biomaterials for inflammatory bowel disease: treatment, diagnosis and organoids DOI
Jia Wang, Yuying Shi,

Bei Mao

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 36, P. 102078 - 102078

Published: Jan. 20, 2024

Language: Английский

Citations

9

Preparation of bright yellow color sodium alginate solution DOI
Tongtong Pan, Xiao Wang, Jiaxin Zhu

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 337, P. 122169 - 122169

Published: April 16, 2024

Language: Английский

Citations

9

Enhancing Osteogenic Potential in Bone Tissue Engineering: Optimizing Pore Size in Alginate–Gelatin Composite Hydrogels DOI Creative Commons
Zied Ferjaoui, Roberto López‐Muñoz, Soheil Akbari

et al.

Advanced Engineering Materials, Journal Year: 2024, Volume and Issue: 26(13)

Published: May 13, 2024

Bone tissue engineering relies on crucial scaffolds for formation and stem cell differentiation. A composite scaffold of alginate‐gelatin effectively supports these processes. This study aims to design a porous hydrogel assess pore size effects behavior, focusing morphology, adhesion, proliferation in distinct osteogenic environments. Hydrogels are prepared using various concentrations: 4% alginate 6% gelatin (4A6G) or 3% 5% (3A5G), cross‐linked with 2% CaCl2. Pore optimization employs simple freezing thawing cycles. Scanning electron microscopy reveals varying sizes: 340 µm ± 30 4A6G 635 25 3A5G. Stiffness measurements indicate significant differences: ≈26.3 kPa 0.6 KPa 21.6 0.2 Cell interaction studies demonstrate higher adhesion rates larger‐pored hydrogels. Evaluation bone formation, including RT‐PCR, ALP activity, ARS staining, reveal superior potential the 3A5G compared 4A6G. In conclusion, (3% gelatin) holds promise regeneration due its biodegradability favorable bone‐forming properties.

Language: Английский

Citations

8

Recent Progress in Alginate-based Nanocomposites for Bone Tissue Engineering Applications DOI

Sundaravadhanan Lekhavadhani,

Sushma Babu,

Abinaya Shanmugavadivu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114570 - 114570

Published: Feb. 18, 2025

Language: Английский

Citations

1

Current issues and potential solutions for the electrospinning of major polysaccharides and proteins: A review DOI
Murtaza Syed, Md. Maksudur Rahman Khan, Mior Ahmad Khushairi Mohd Zahari

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126735 - 126735

Published: Sept. 9, 2023

Language: Английский

Citations

16

Principles and Design of Bionic Hydrogel Adhesives for Skin Wound Treatment DOI Open Access

Chunxiao Wang,

Xinyu Zhang,

Yinuo Fan

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1937 - 1937

Published: July 6, 2024

Over millions of years evolution, nature has developed a myriad unique features that have inspired the design adhesives for wound healing. Bionic hydrogel adhesives, capable adapting to dynamic movements tissues, possess superior biocompatibility and effectively promote healing both external internal wounds. This paper provides systematic review principles these focusing on treatment skin wounds, explores feasibility incorporating nature-inspired properties into their design. The adhesion mechanisms bionic are analyzed from chemical physical perspectives. Materials natural synthetic polymers commonly used as detailed regarding degradability. multifunctional elements trauma treatment, such self-healing, drug release, responsive design, optimization mechanical properties, further explored. aim is overcome limitations conventional treatments offer safer, more effective solution application dressings.

Language: Английский

Citations

5

Orally ingestible medication utilizing layered double hydroxide nanoparticles strengthened alginate and hyaluronic acid-based hydrogel bead for bowel disease management DOI
Ngọc Tuấn Nguyễn, Bich-Phuong Thi Nguyen,

Tuyet-Nhung Ho

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132122 - 132122

Published: May 6, 2024

Language: Английский

Citations

3