Novel bioactive and biocompatible alumina-wollastonite porous constructs mimicking physical properties of human cortical bone DOI Creative Commons
Manuela González-Sánchez, Camilo Zamora‐Ledezma, Jeevithan Elango

et al.

Journal of the European Ceramic Society, Journal Year: 2024, Volume and Issue: 44(7), P. 4699 - 4708

Published: Feb. 3, 2024

A new procedure for the bioactivation of alumina-based porous ceramic constructs was introduced. The were built with aim mimicking structural and mechanical properties human cortical bone. Bioactivation achieved by adding wollastonite acidic surface treatment (piranha solution). Structural studies (SEM, CAT) confirmed that adequate pore size interconnectivity obtained. Uniaxial compression tests showed values Young's moduli compressive strength reduced, from 5 to 1 GPa, 45 15 MPa, respectively, as content increased 0 40 wt%. Proliferative, histological fluorescence results cell proliferation rate bone-marrow-derived mesenchymal stem cells significantly enhanced increasing content. No cytotoxic effect observed. In summary, fabricated bioceramics exhibited suggestive they could be useful practical bone tissue engineering applications without any adverse biological effects.

Language: Английский

Novel bioactive and biocompatible alumina-wollastonite porous constructs mimicking physical properties of human cortical bone DOI Creative Commons
Manuela González-Sánchez, Camilo Zamora‐Ledezma, Jeevithan Elango

et al.

Journal of the European Ceramic Society, Journal Year: 2024, Volume and Issue: 44(7), P. 4699 - 4708

Published: Feb. 3, 2024

A new procedure for the bioactivation of alumina-based porous ceramic constructs was introduced. The were built with aim mimicking structural and mechanical properties human cortical bone. Bioactivation achieved by adding wollastonite acidic surface treatment (piranha solution). Structural studies (SEM, CAT) confirmed that adequate pore size interconnectivity obtained. Uniaxial compression tests showed values Young's moduli compressive strength reduced, from 5 to 1 GPa, 45 15 MPa, respectively, as content increased 0 40 wt%. Proliferative, histological fluorescence results cell proliferation rate bone-marrow-derived mesenchymal stem cells significantly enhanced increasing content. No cytotoxic effect observed. In summary, fabricated bioceramics exhibited suggestive they could be useful practical bone tissue engineering applications without any adverse biological effects.

Language: Английский

Citations

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