Organocyclophosphazenes and Materials Based on Them for Pharmaceuticals and Biomedicine

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 262 - 262

Published: Feb. 11, 2025

This review examines representatives of organocyclophosphazenes that can act against tumor cells the ovaries, prostate gland, mammary and colon, etc., have antimicrobial action mycobacteria M. tuberculosis, Gram-positive bacteria B. cereus, Gram-negative K. pneumaniae, fungi genus Candida, other microorganisms. Cyclomatric phosphazenes be used as carriers physiologically active substances in field detection, well gels for wound surgery drug delivery platforms. In gels, cyclophosphazenes are cross-linking agents. Cyclophosphazenes containing multiple bonds organic radicals proposed to dentistry additives basic dental compositions. Particular attention is paid cytotoxic materials their advantages over commercial substances. The presents prospects practical application various functional groups (chalcone, anthraquinone, pyrrolidine, morpholine, ferrocene, etc.) pharmaceuticals. may interest researchers working organoelement chemistry, medicine, pharmacy.

Language: Английский

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The Effectiveness of Silver Nanoparticles Mixed with Calcium Hydroxide against Candida albicans: An Ex Vivo Analysis

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 289 - 289

Published: Jan. 29, 2024

Introduction: The purpose of this study was to assess the antifungal activity silver nanoparticles (AgNPs) in combination with calcium hydroxide (Ca(OH)2) against Candida albicans (C. albicans). Methods: AgNPs mixed pure Ca(OH)2 powder an aqueous base. A standard suspension (1 × 108 bacterial cells/mL) C. prepared a 96-well plate and incubated on shaker at 37 °C 100% humidity allow fungal biofilm formation infected dentin slices (n = 98). minimum inhibitory concentration (MIC) fungicidal (MFC) alone or were determined. samples separately placed 24-well tissue culture plates divided into three experimental groups (0.03, 0.04, 0.06) control groups; negative (saline) positive chlorhexidine gel Ca(OH)2. Quantitative measurements by XTT colorimetric assay qualitative using confocal laser microscopy scanning electron performed. Results: cell viability significantly reduced compared group. (AgNPs (0.04%) Ca(OH)2) most potent albicans. Conclusions: findings demonstrated that combining more effective alone, suggesting combing effect.

Language: Английский

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Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1798 - 1798

Published: June 25, 2024

Anti-inflammatory wound healing involves targeted drug delivery to the site using hydrogel materials prolong effectiveness. In this work, films were fabricated carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked with citric acid (CA) glutaraldehyde (GA) at different concentrations. The crosslinker densities optimized various CA (2–10% w/v) GA (1–5% v/v) crosslink in exhibited additional functional group peaks FT-IR spectra 1740 cm−1 for C=O stretching of ester linkage 1060 C-O-C ether GA. Significantly, internal porous structures composite improved density, swelling capacities, solubility percentage reduction, decreased water retention capacities densities. Therefore, these utilized as carriers controlled release within 24 h during medical treatment. Moreover, demonstrated increased triamcinolone acetonide (TAA) absorption higher resulting delayed TAA efficiency anti-inflammatory activity. As a result, modified showed capability being an alternative material enhanced films.

Language: Английский

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Influence of ZnO Nanoparticles on the Properties of Ibuprofen-Loaded Alginate-Based Biocomposite Hydrogels with Potential Antimicrobial and Anti-Inflammatory Effects

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2240 - 2240

Published: Aug. 30, 2023

Hydrogels are a favorable alternative to accelerate the burn wound healing process and skin regeneration owing their capability of absorbing contaminated exudates. The bacterial infections that occur in wounds might be treated using different topically applied materials, but resistance antibiotics has become major problem worldwide. Therefore, use non-antibiotic treatments represents interest current research. In this study, new antibiocomposite hydrogels with anti-inflammatory antimicrobial properties based on hyaluronic acid (HA) sodium alginate (AG) were obtained 4-(4,6-dimethoxy-1,3,5-triazinyl-2)-4-methylmorpholinium chloride as an activator. combination Ibuprofen, non-steroidal drug commonly used reduce inflammation, fever pain body, zinc oxide nanoparticles (ZnO NPs) was study aimed at creating complex hydrogel action capable improving caused by burns. FTIR spectra confirmed cross-linking AG HA well successful incorporation ZnO NPs. Using electronic microscopy, it noticed morphology is influenced nanoparticles. Moreover, into also influence swelling behavior both pH 7.4 5.4. fact, rate lower when amounts activator, NPs high. A release almost 100% observed for without NPs, whereas addition led decrease 68% during 24 h. Cellular viability tests demonstrated non-cytotoxic weak moderate cytotoxic effect containing 4% 5% respectively, showed good activity against S. aureus strain. These preliminary data prove these types can biomaterials treatment wounds.

Language: Английский

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Antibacterial, Antibiofilm, and Wound Healing Activities of Rutin and Quercetin and Their Interaction with Gentamicin on Excision Wounds in Diabetic Mice

Biology, Journal Year: 2024, Volume and Issue: 13(9), P. 676 - 676

Published: Aug. 29, 2024

Phytochemicals are effective and gaining attention in fighting against drug-resistant bacterial strains. In the present study, rutin quercetin were tested for antibacterial, antibiofilm, wound healing activities on excision wounds infected with MDR-P. aeruginosa diabetic mice. Antibacterial antibiofilm studied vitro using broth dilution assay crystal violet assay, respectively. These phytochemicals alone wound-healing at different concentrations (0.5% 1% ointment base) combination gentamicin to evaluate any additive effects. Rutin demonstrated effectiveness higher concentrations. Both inhibited biofilm formation contributed of by eradicating wounded tissue. a low concentration (0.5%) had lesser effect reducing epithelization period regeneration epithelial layer compared quercetin. When combined gentamicin, (1%) displayed maximum epithelium regeneration, followed gentamicin. found be more controlling when used as an The study supports traditional use managing infections.

Language: Английский

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Enhancing Mechanical and Antimicrobial Properties of Dialdehyde Cellulose–Silver Nanoparticle Composites through Ammoniated Nanocellulose Modification

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 2065 - 2065

Published: April 30, 2024

Given the widespread prevalence of viruses, there is an escalating demand for antimicrobial composites. Although composite dialdehyde cellulose and silver nanoparticles (DAC@Ag1) exhibits excellent antibacterial properties, its weak mechanical characteristics hinder practical applicability. To address this limitation, nanofibers (CNFs) were initially ammoniated to yield N-CNF, which was subsequently incorporated into DAC@Ag1 as enhancer, forming DAC@Ag1/N-CNF. We systematically investigated optimal amount N-CNF characterized DAC@Ag1/N-CNF using FT-IR, XPS, XRD analyses evaluate additional properties. Notably, mass ratio found be 5:5, resulting in a substantial enhancement with 139.8% increase tensile elongation 33.1% strength, reaching 10% 125.24 MPa, respectively, compared alone. Furthermore, inhibition zones against Escherichia coli Staphylococcus aureus significantly expanded 7.9 mm 15.9 mm, surpassing those alone by 154.8% 467.9%, indicating remarkable improvements efficacy. Mechanism analysis highlighted synergistic effects from chemical covalent bonding hydrogen DAC@Ag1/N-CNF, enhancing properties significantly. The addition markedly augmented film, thereby facilitating broader application field.

Language: Английский

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Review of carbonaceous nanoparticles for antibacterial uses in various dental infections

Nanotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36

Published: Jan. 30, 2025

The mouth cavity is the second most complex microbial community in human body. It composed of bacteria, viruses, fungi, and protozoa. An imbalance oral microbiota may lead to various conditions, including caries, soft tissue infections, periodontitis, root canal peri-implantitis (PI), pulpitis, candidiasis, denture stomatitis. Additionally, several locally administered antimicrobials have been suggested for dentistry surgical non-surgical applications. main drawbacks are increased antimicrobial resistance, risk upsetting natural microbiota, hypersensitivity responses. Because their unique physiochemical characteristics, nanoparticles (NPs) can circumvent antibiotic-resistance mechanisms exert action via a variety new bactericidal routes. anti-microbial properties, carbon-based NPs becoming more effective antibacterial agents. Periodontitis, PI, dentin other dental diseases among conditions that be treated using carbon (CNPs) like graphene oxide dots. outline scientific development multifunctional CNPs concerning disorders will given before talking about significant influence on health. Some these illnesses include pulp disorders, PI. We also review remaining research application barriers possible future problems.

Language: Английский

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Progress in the Field of Cyclophosphazenes: Preparation, Properties, and Applications

Polymers, Journal Year: 2023, Volume and Issue: 16(1), P. 122 - 122

Published: Dec. 29, 2023

This review article provides a comprehensive overview of recent advancements in the realm cyclophosphazenes, encompassing their preparation methodologies, distinctive properties, and diverse applications. The synthesis approaches are explored, highlighting these cyclic compounds. discussion extends to properties exhibited by including thermal stability characteristics, other relevant features. Furthermore, we examine broad spectrum applications for cyclophosphazenes various fields, such as coatings, adhesives, composites, extractants, metal complexes, organometallic chemistry, medicine, inorganic chemistry. aims offer insights into evolving landscape ever-expanding roles contemporary scientific technological arenas. Future possibilities emphasized, significant research data shortages identified.

Language: Английский

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Nano boron nitride laminated poly(ethyl methacrylate)/poly(vinyl alcohol) composite films imprinted with silver nanoparticles as gas barrier and bacteria resistant packaging materials

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: 141(16)

Published: Feb. 2, 2024

Abstract Herein, nano boron nitride (BN) laminated poly(ethyl methacrylate) (PEMA)/poly(vinyl alcohol) (PVA) nanocomposite films are fabricated by using a simple in situ polymerization technique with incorporation of silver nanoparticles (Ag NPs). Structural investigations PEMA/PVA/Ag@BN thin carried out Fourier‐transform infrared spectroscopy, dynamic light scattering, X‐ray diffraction analysis, 1 H nuclear magnetic resonance, 13 C and mass spectrometry. The change morphology PEMA/PVA matrix due to the reinforcement BN platelets identified electron microscopic studies. unique tortuous paths achieved dispersion which gas penetration is restricted enhancing barrier properties material 6.5 folds at 5 wt% content as compared neat PEMA/PVA. Acid alkali resistant along biodegradability behavior as‐synthesized nanocomposites studied. From limiting oxygen index (LOI) results, it found that prepared materials fire retardant nature owing effective layers. Antibacterial activities studied Xanthomonas citri or axonopodis pv. Citri , Escherichia coli oryzae Oryzae because Ag NPs reinforcement. substantial improvements barrier, retardant, antibacterial enable for packaging application.

Language: Английский

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Silver Nanoparticles From Cassia alata L. Incorporated to Coconut Oil‐Oleogel Based Ointment As An Alternative for Diabetes Mellitus Wound Healing: Optimization, In Vitro and In Vivo Tests

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(12)

Published: March 21, 2024

Abstract Diabetes mellitus, a widespread chronic illness categorized by elevated blood sugar levels, poses significant health burden. This study aimed to synthesize an optimal oleogel formula and investigate its impact on accelerating diabetic wound healing through multidimensional approach. The evaluation spanned in vitro examination utilizing bacterial cultures, vivo assessments mice, involving meticulous 9‐day observation of percentages. successful synthesis characterization AgNPs Na‐CMC laid the foundation for further exploration. Oleogel formulation optimization using Response Surface Methodology (RSM) revealed most effective composition featuring at 4.5 %, beeswax 12.5 stirring temperature 80 °C. Manufacturing success was affirmed comprehensive testing encompassing pH, organoleptic properties, dispersion, gelation time, FTIR analyses. Characteristics extracted nanoparticles were scrutinized SEM‐EDX, PSA, Zetapotential tests. In evaluations showcased commendable antibacterial activity AgNPs. Notably, observations highlighted superior capabilities ointment enriched with These findings collectively underscore promising potential synthesized promoting process wounds, validated diverse analytical approaches, marking stride toward therapeutic interventions diabetes‐related management.

Language: Английский

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