Applied Surface Science, Journal Year: 2024, Volume and Issue: 687, P. 162211 - 162211
Published: Dec. 27, 2024
Language: Английский
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: March 7, 2025
Diabetes is a widespread metabolic disorder that presents considerable challenges in its management. Recent advancements biomaterial research have shed light on innovative approaches for the treatment of diabetes. This review examines role biomaterials diabetes diagnosis and treatment, as well their application managing diabetic wounds. By evaluating recent developments alongside future obstacles, highlights promising potential care, underscoring importance enhancing patient outcomes refining methodologies.
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1129 - 1129
Published: April 22, 2025
Chronic wounds, particularly those associated with conditions like diabetes, present significant challenges in healthcare due to prolonged healing and high susceptibility infections. This study investigates the development of injectable hydrogels composed genipin-crosslinked gelatin Kelulut honey (KH) as novel biomaterials for wound applications. Hydrogels were prepared varying concentrations (w/v) (9% 10%) KH (0.1% 0.5%), genipin (0.1%) acting a crosslinker. The physicochemical properties extensively evaluated, including swelling ratio, water vapor transmission rate (WVTR), contact angle, porosity, enzymatic degradation, surface roughness. results showed that incorporation significantly enhanced hydrogels, 9GE_0.1KH formulation demonstrating ratio 742.07 ± 89.61% compared 500% control 9GE formulation. WVTR values KH-incorporated ranged from 1670.60 236.87 g/m2h 2438.92 190.90 g/m2h, which within ideal range (1500–2500 g/m2h) healing. Contact angle measurements indicated improved hydrophilicity, showing 42.14° 7.52° 60° 11.66° 10GE Biodegradation rates slightly higher KH-modified (0.079 0.006 mg/h 9GE_0.1KH), but all remained acceptable limits. These findings suggest gelatin-KH offer promising scaffold potential applications tissue engineering three-dimensional (3D) bioprinting technologies.
Language: Английский
Citations
0
Burns, Journal Year: 2025, Volume and Issue: unknown, P. 107562 - 107562
Published: May 1, 2025
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1305 - 1305
Published: Sept. 30, 2024
Non-healing diabetic wounds represent a significant clinical challenge globally, necessitating innovative approaches in drug delivery to enhance wound healing. Understanding the pathogenesis of these is crucial for developing effective treatments. Bioactive dressings and polymeric nanofibers have emerged as promising modalities, with silk biomaterials gaining attention their unique properties
Language: Английский
Citations
2
Sustainability, Journal Year: 2023, Volume and Issue: 15(23), P. 16541 - 16541
Published: Dec. 4, 2023
The current state of the natural environment requires medical products, including dressings, to be manufactured in accordance with principles a sustainable economy. This assumption is perfectly met by dressings made renewable materials and additionally filled antiseptics. use such plant compounds consistent green chemistry. In this work, films based on Kuzu starch rooibos extract chili pepper oil were prepared tested. Starch foil silver nanoparticles without additives used as comparative material. chemical structures (ATR-FTIR) obtained, their thermal (DSC) mechanical properties (tensile strength, hardness), density, swelling, water vapor permeability, solubility, effects bacteria Staphylococcus aureus ATCC 25923 Escherichia coli 25922 examined. film had lowest antimicrobial activity. At same time, it was most flexible characterized having best permeability absorption capacity. weakest mechanically speaking, but significantly inhibited growth at level similar that nanoparticles. preliminary tests carried out extracts from tea peppers indicate they may suitable for further research dressing materials.
Language: Английский
Citations
1
Polimery, Journal Year: 2023, Volume and Issue: 68(9), P. 461 - 472
Published: Oct. 31, 2023
New types of hydrogels based on linear poly(2-hydroxyethyl methacrylate) and poly(ethyleneglycol) diacrylate (PHEMA-PEGDA) nettle extract were obtained. A solution poly(2-hydroxyethylmethacrylate) in monomer (S-PHEMA) was obtained by bulk photopolymerization. Common extractwas used as an ingredient that facilitates wound healing. The influence the photoinitiator content(1-[4-(2-hydroxymethyl)-phenyl]-2-hydroxy-2-methylpropanone) photopolymerization kinetics,as well equilibrium swelling ratio (ESR), thermal mechanical properties hydrogelswere examined. Complete HEMA conversion achieved at lowest dose. ReplacingHEMA with S-PHEMA causes increase ESR (24%) Tg (50°C) amorphous phase content.At same time, tensile strength Young’s modulus decrease. However, addition nettleextract (0.3 wt%) requires a significant amount (up to 2.5 wt%). As theconcentration system increases, decrease, but strengthand increase.
Language: Английский
Citations
1
e-Journal of Surface Science and Nanotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 13, 2024
This study explored the fabrication of chitosan-polyethylene glycol-beeswax (CS-PEG-BW) as hydrogel dressings. Different formulation settings with varying BW concentrations were prepared to determine influence into hydrophilicity, swellability, antibacterial, and hemocompatibility CS-PEG-BW network. Fourier transform infrared (FTIR) spectroscopy analysis samples confirmed interactions brought by positively charged CS electronegative PEG. The emulsion CS-PEG network made no significant changes on structure. In terms properties, addition showed improvements in antibacterial properties while property %Hemolysis remained almost equal all hydrogels. calculated surface free energy increased polar groups concentration increased, leading improvement ionic sensitivity hydrogels during swelling tests. Lastly, presence higher better activity against S. aureus. resulting found be non-hemolytic substances that can hold moisture inhibit bacterial growth. shows potential wound
Language: Английский
Citations
0
International Journal of Complementary & Alternative Medicine, Journal Year: 2024, Volume and Issue: 17(5), P. 240 - 246
Published: Jan. 1, 2024
Diabetes mellitus (DM) hyperglycemia may lead to hyperplasia and micro vascular dysfunction delays wound healing process by increasing reactive oxygen species (ROS) accompanied low levels of inflammatory cytokines an increase in matrix metalloproteinases (MMPs). Consequently, prolonged with the worst complication diabetic foot ulcers (DFUs) as when it fails heal fating limb amputation. Apitherapeutic (honey propolis) dressing achieved successful accelerated infection control action their antimicrobial, anti-inflammatory antioxidant properties. The present review dealt activity DFUs study of: vitro antimicrobial against isolated pathogens, towards immune cellular elements vivo application for induced animal models well topical patients either natural or nanoformulated scaffold dressings. Available literatures proved synergistic different mixed apitherapeutic products together recommended be used formula naturally nanoformulation.
Language: Английский
Citations
0
Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3594 - 3594
Published: Dec. 22, 2024
It is a real honor for me to be the Guest Editor of this Special Issue and continue project with second edition “Sustainable Biopolymer-Based Composites: Processing, Characterization Application II” [...]
Language: Английский
Citations
0
Applied Surface Science, Journal Year: 2024, Volume and Issue: 687, P. 162211 - 162211
Published: Dec. 27, 2024
Language: Английский
Citations
0