Insulin-Loaded Chitosan–Cellulose-Derivative Hydrogels: In Vitro Permeation of Hormone through Strat-M® Membrane and Rheological and Textural Analysis DOI Open Access
Aneta Ostróżka-Cieślik, Claire Strasser, Barbara Dolińska

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2619 - 2619

Published: Sept. 16, 2024

This work is part of the current research trend to develop a hydrogel carrier insulin promote wound healing. Topically applied promotes keratinocyte proliferation and migration, increases collagen synthesis, reduces inflammation oxidative stress, exhibits antimicrobial activity. The aim this study was design an matrix based on selected cellulose derivatives (methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose) chitosan. Rheological parameters formulations were evaluated using rotational rheometry oscillation test. Textural tests performed. In vitro pharmaceutical availability studies carried out innovative Strat-M® membrane imitate skin barrier. It found that formulation chitosan methylcellulose showed acceptable balance between rheological textural ease application. API released from in prolonged manner, eliminating need apply several times per day. developed shows potential for use clinical practice.

Language: Английский

O-carboxymethyl chitosan in biomedicine: A review DOI

Lingbin Chen,

Yandi Xie,

Xiaohang Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133465 - 133465

Published: June 28, 2024

Language: Английский

Citations

14
Harnessing the immunomodulatory potential of chitosan and its derivatives for advanced biomedical applications DOI
Doğukan Duymaz, Aybaran Olca Kebabci, Seda Kızılel

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142055 - 142055

Published: March 1, 2025

Language: Английский

Citations

1
Nutraceuticals Targeting Cannabinoid Receptor 1 and Transient Receptor Potential Vanilloid 1 for Pain Relief: A Computational Screening Approach DOI Open Access
Tayyaba Hasan, Mostafa Mohammadi,

Ali Jabbari

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 6, 2025

This study examined the binding affinities and therapeutic potential of natural products targeting pain-related receptors using molecular docking dynamics (MD) simulations. Drug-like properties absorption, distribution, metabolism, excretion, toxicity (ADMET) analyses were also conducted. AutoDock Vina (The Scripps Research Institute, La Jolla, CA, USA) was used for against receptors, including transient receptor vanilloid 1 (TRPV1), cyclooxygenase-2 (COX-2), cannabinoid (CB1), mu-opioid receptor, nicotinic acetylcholine receptors. Celecoxib included as a reference drug score comparison. Protein-ligand complex stability assessed via 100-nanosecond (ns) MD simulations GROMACS (GROningen MAchine Chemical Simulations; University Groningen, Netherlands), analyzing root mean square deviation (RMSD) radius gyration (Rg). Drug-likeness evaluated by Lipinski's rule five, ADMET analysis performed pharmacokinetics profiling. Ginsenoside Rb1 exhibited strong affinity TRPV1 (-9.5 kcal/mol) (-9.0 suggesting its non-opioid analgesic candidate. Cyanidin 3-O-rutinoside demonstrated high to (-9.35 kcal/mol), COX-2 (-9.65 CB1 (-9.18 surpassing celecoxib (-7.22 in binding. confirmed stability, with RMSD (~3.0 Å) Rg nm) values lower than unbound proteins. Most compounds met criteria, indicating good oral bioavailability. revealed favorable absorption distribution low toxicity. cyanidin exhibit affinity, pharmacokinetic properties, supporting their candidates. Their ability modulate pain pathways vitro vivo warrants further investigation.

Language: Английский

Citations

0
Techniques and applications in 3D bioprinting with chitosan bio-inks for drug delivery: A review DOI
Zhaomin Yao,

Xin Feng,

Zheling Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134752 - 134752

Published: Aug. 30, 2024

Language: Английский

Citations

3
Nano-enhanced immunity: A bibliometric analysis of nanoparticles in vaccine adjuvant research DOI Creative Commons
Manal Mohamed Elhassan Taha, Mohamed Yousif Ibrahim, Sivakumar S. Moni

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: Nov. 14, 2024

This study analyzed the growth, collaboration, citation trends, and emerging topics in nanoparticle-based vaccine adjuvant research (NVAR) from 1977 to 2023, using data Scopus database. The field showed a steady growth rate of 7.53% per year. Leading researchers Jaafari, M.R. Alving, C.R. contributed significantly field, with 24.22% publications 38.92% total citations coming United States. International collaboration was very strong, particularly between US, UK, Germany, China, France. Key include nanoparticles, immunotherapy, COVID-19, vaccines focus on SARS-CoV-2 malaria. Emerging adjuvants, mRNA, neutralizing antibodies. emphasizes importance ongoing interdisciplinary efforts advance NVAR.

Language: Английский

Citations

3
Insulin-Loaded Chitosan–Cellulose-Derivative Hydrogels: In Vitro Permeation of Hormone through Strat-M® Membrane and Rheological and Textural Analysis DOI Open Access
Aneta Ostróżka-Cieślik, Claire Strasser, Barbara Dolińska

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2619 - 2619

Published: Sept. 16, 2024

This work is part of the current research trend to develop a hydrogel carrier insulin promote wound healing. Topically applied promotes keratinocyte proliferation and migration, increases collagen synthesis, reduces inflammation oxidative stress, exhibits antimicrobial activity. The aim this study was design an matrix based on selected cellulose derivatives (methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose) chitosan. Rheological parameters formulations were evaluated using rotational rheometry oscillation test. Textural tests performed. In vitro pharmaceutical availability studies carried out innovative Strat-M® membrane imitate skin barrier. It found that formulation chitosan methylcellulose showed acceptable balance between rheological textural ease application. API released from in prolonged manner, eliminating need apply several times per day. developed shows potential for use clinical practice.

Language: Английский

Citations

0