Viruses,
Journal Year:
2024,
Volume and Issue:
16(1), P. 77 - 77
Published: Jan. 3, 2024
Enhancing
cross-protections
against
diverse
influenza
viruses
is
desired
for
vaccinations.
Neuraminidase
(NA)-specific
antibody
responses
have
been
found
to
independently
correlate
with
a
broader
protection
spectrum.
Here,
we
report
sequential
immunization
regimen
that
includes
priming
NA
protein
followed
by
boosting
peptide
nanoclusters,
which
targeted
enhancement
of
in
BALB/c
mice
certain
cross-protective
B-cell
epitopes
was
achieved.
The
nanoclusters
were
fabricated
via
desolvation
absolute
ethanol
and
only
composed
composite
peptides.
Unlike
KLH
conjugates,
would
not
induce
influenza-unrelated
immunity.
We
the
incorporation
hemagglutinin
H2-d
class
II
restriction
into
peptides
could
be
beneficial
enhancing
peptide-specific
response.
Of
note,
boosters
N2
induced
stronger
serum
cross-reactivities
heterologous
even
heterosubtypic
N7
N9
than
triple
immunizations
prototype
recombinant
tetrameric
(rt)
N2.
mouse
challenge
experiments
HK68
H3N2
also
demonstrated
strong
effectiveness
nanocluster
conferring
protection.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Abstract
Nanocatalytic
platforms
are
promising
in
cancer
therapeutics
via
combining
multiple
treatments,
which
can
be
leveraged
through
the
metabolic
dysfunction
progression.
However,
lack
of
effective
tumor
delivery
hampers
this
approach.
Here,
a
gelatin‐based
platform
is
designed
that
preloaded
with
gold
nanoparticles
and
photothermal
polypyrrole
(GNPs@AuNPs‐PPy)
an
acid‐induced
doping
enhancement.
Benefiting
from
associated
overexpression
H
2
O
,
peroxidase‐like
Au
induce
burst
oxidative
reactive
oxygen
species
local
microenvironment
(TME).
Subsequent
orchestration
redox
surroundings
recruits
immune
cells,
showcasing
antineoplastic
pathway.
Under
near
infrared
light
(NIR)
irradiation,
nanohybrids
exhibit
dual
pH/NIR
enhanced
drug
release
within
TME,
while
allowing
for
multimodal
imaging‐guided
theranostics.
Leveraging
modality,
GNPs@AuNPs‐PPy
delivers
quercetin
(a
natural
antitumor
mediator)
boosting
anti‐tumor
therapy.
The
gelatin‐mediated
nanomedicine
provides
alternative
combinatorial
dynamic
treatment.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 25, 2025
Diabetes
is
a
growing
global
health
issue,
with
millions
of
people
affected
by
the
condition.
While
insulin
therapy
vital
for
managing
both
Type
1
and
2
diabetes,
traditional
methods
such
as
subcutaneous
injections
have
notable
drawbacks,
including
pain,
discomfort,
difficulty
in
maintaining
stable
blood
sugar
levels.
To
improve
delivery,
research
increasingly
focused
on
use
natural
polymers—substances
derived
from
plants,
animals,
microorganisms.
These
polymers,
materials
like
alginate,
chitosan,
hyaluronic
acid,
promising
properties
biocompatibility,
biodegradability,
ability
to
provide
controlled,
sustained
release.
By
encapsulating
it
protected
degradation
released
manner
that
more
closely
mirrors
body’s
production.
Furthermore,
development
non-invasive
delivery
methods,
oral
transdermal
systems,
gaining
momentum,
offering
potential
patient-friendly
treatment
options.
This
review
discusses
role
polymers
examining
their
mechanisms,
types,
current
efforts.
It
also
addresses
challenges
remain
advancing
these
technologies
into
practical
clinical
use,
aiming
efficient,
comfortable,
effective
solutions
diabetes
management.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(1), P. 127 - 127
Published: Jan. 9, 2025
Fungal
infections
represent
a
significant
global
health
challenge.
Candida
albicans
is
particularly
widespread
pathogen,
with
both
molecular
and
biofilm-based
mechanisms
making
it
resistant
to
or
tolerant
of
available
antifungal
drugs.
This
study
reports
combination
therapy,
active
against
C.
albicans,
utilizing
terbinafine
essential
oils
incorporated
into
gelatin-based
nanoemulsion
system
(T-GNE).
Eugenol
methyl
eugenol/terbinafine
T-GNEs
had
an
additive
efficacy,
while
carvacrol
(CT-GNE)
worked
synergistically
terbinafine,
providing
effective
treatment
minimal
mammalian
cell
toxicity.
Confocal
microscopy
demonstrated
that
CT-GNE
penetrated
the
dense
biofilm
disrupted
fungal
membrane.
Overall,
in
GNE
provided
promising
for
biofilms.
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 130 - 130
Published: Feb. 11, 2025
Spray-drying
is
a
common
technique
for
the
microencapsulation
of
bioactive
compounds,
which
crucial
improving
their
stability
and
bioavailability.
In
this
study,
encapsulation
efficiency
(EE),
physicochemical
properties
in
vitro
bioaccessibility
phenolic
compounds
from
spray-dried
encapsulated
phenol-rich
extracts
grape
pomace,
winery
waste,
were
evaluated.
Sodium
alginate
alone
(SA)
or
mixture
with
gum
Arabic
(SA-GA)
gelatin
(SA-GEL)
was
used
as
coating.
SA-GEL
achieved
highest
EE
(95.90–98.01%)
outperformed
intestinal
release
phenolics
by
achieving
index
(BI)
total
37.8–96.2%.
The
mechanism
microcapsules
adhered
to
Fickian
diffusion.
Encapsulation
significantly
improved
BI
individual
phenolics,
values
gallocatechin
gallate
(2028.7%),
epicatechin
(476.4%)
o-coumaric
acid
(464.2%)
obtained
microcapsules.
Structural
analysis
confirmed
amorphous
matrices
all
systems,
solubility
stability.
These
results
suggest
that
spray-drying
effectively
protects
during
digestion
ensures
efficient
intestine,
improves
bioaccessibility.
This
study
contributes
understanding
biopolymer-based
but
also
valorisation
pomace
high-value
functional
ingredient
sustainable
food
processing.
International Journal of Applied Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 53 - 64
Published: March 7, 2025
Made
from
a
variety
of
natural
sources,
Nano
Crystalline
Cellulose
(NCC)
is
unique
renewable
nanomaterial
with
wide
range
applications
due
to
its
high
stiffness
and
strength,
low
weight,
biodegradability,
environmental
benefits.
Because
special
inherent
qualities,
NCC
one
the
most
materials
be
addressed
by
nanomaterials.
The
origins,
manufacture,
characteristics,
nanomaterials,
including
nanofibers,
have
been
extensively
studied
large
number
researchers
throughout
years.
Strong
chemical
reactivity,
crystallinity,
strength
stiffness,
biocompatibility,
shape,
nanoscale
dimensions
are
just
few
remarkable
properties
that
these
nanomaterials
shown
possess
in
countless
investigations.
These
characteristics
enable
application
nanoparticles
fields,
medicine.
Among
traditional
popular
techniques.
Electrospinning
earliest
techniques
for
producing
nanofibers.
This
method
works
well
can
modified
produce
continuous
NCC-based
nanofibers
novel
biomaterials
industry.
Recent
studies
demonstrated
electrospun
could
efficiently
loaded
drugs,
such
as
proteins,
chemotherapeutic
agents,
antibiotics,
analgesics
anti-inflammatory
qualities.
One
medical
field
drug
delivery.
review
highlights
issues
related
their
use
delivery
applications,
beginning
discussing
various
polymer
types
used
physicochemical
biological
NCC,
significance,
preparation
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(4), P. 722 - 722
Published: March 24, 2025
Multidrug-resistant
tuberculosis
(MDR-TB)
is
a
significant
public
health
challenge
globally,
exacerbated
by
the
limited
efficacy
of
existing
therapeutic
approaches,
prolonged
treatment
duration,
and
severe
side
effects.
As
drug
resistance
continues
to
emerge,
innovative
delivery
systems
strategies
are
critical
combating
this
crisis.
This
review
highlights
molecular
mechanisms
underlying
drugs
in
Mycobacterium
tuberculosis,
such
as
genetic
mutation,
efflux
pump
activity,
biofilm
formation,
contributing
persistence
difficulty
eradicating
MDR-TB.
Current
options,
including
second-line
drugs,
offer
effectiveness,
prompting
need
for
innovation
advanced
therapies
systems.
The
progression
discovery
has
resulted
approval
therapeutics,
bedaquiline
delamanid,
amongst
other
promising
candidates
under
investigation.
However,
overcoming
limitations
traditional
remains
challenge.
Nanotechnology
emerged
solution,
with
nanoparticle-based
offering
improved
bioavailability
targeted
controlled
release
delivery,
particularly
pulmonary
targeting
intracellular
macrophages.
Furthermore,
development
inhalable
formulations
potential
nanomedicines
bypass
presents
novel
approach
enhancing
efficacy.
Moreover,
adjunctive
therapies,
immune
modulation
host-directed
being
explored
improve
outcomes.
Immunotherapies,
cytokine
TB
vaccines,
complementary
use
antibiotics
Personalized
medicine
leveraging
genomic
profiling
both
pathogen
host,
promise
optimizing
regimens
minimizing
resistance.
underscores
importance
multidisciplinary
combining
discovery,
system
development,
address
complexities
treating
Continued
innovation,
global
collaboration,
diagnostics
essential
developing
practical,
accessible,
affordable
treatments
Materials,
Journal Year:
2025,
Volume and Issue:
18(9), P. 2124 - 2124
Published: May 5, 2025
Natural
biomaterials
have
gained
significant
attention
in
modern
dentistry
due
to
their
biocompatibility,
biodegradability,
and
low
immunogenicity.
These
materials,
including
alginate,
cellulose,
chitosan,
collagen,
hydroxyapatite,
been
widely
explored
for
applications
stomatology.
They
play
a
crucial
role
periodontal
disease
treatment,
caries
prevention,
implantology,
providing
an
alternative
synthetic
materials.
polymers
such
as
chitosan
cellulose
are
utilized
drug
delivery
systems
tissue
regeneration,
while
hydroxyapatite
serves
bone
substitute
its
osteoconductive
properties.
Collagen-based
scaffolds
coatings
enhance
regeneration.
Additionally,
bioengineered
chemically
modified
offer
improved
mechanical
biological
characteristics,
expanding
clinical
applications.
This
review
aims
provide
comprehensive
analysis
of
the
properties,
advantages,
limitations
selected
natural
dentistry.
It
explores
various
aspects
stomatology,
prevention
dental
substitutes
implant
coating.
Although
exhibit
promising
further
research
is
necessary
refine
performance,
stability,
ensure
long-term
safety.
Advancements
nanotechnology
bioengineering
continue
drive
development
innovative
biomaterials,
paving
way
more
effective
biocompatible
therapies.
