International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134198 - 134198
Published: July 30, 2024
Language: Английский
Computational and Structural Biotechnology Journal, Journal Year: 2024, Volume and Issue: 23, P. 2442 - 2452
Published: May 23, 2024
Bioactive peptides are short amino acid chains possessing biological activity and exerting physiological effects relevant to human health. Despite their therapeutic value, identification remains a major problem, as it mainly relies on time-consuming in vitro tests. While bioinformatic tools for the of bioactive available, they focused specific functional classes have not been systematically tested realistic settings. To tackle this peptide sequences functions were here gathered from variety databases generate unified collection microbial fermentation. This was organized into nine including some previously studied unexplored such immunomodulatory, opioid cardiovascular peptides. Upon assessing sequence properties, four alternative encoding methods combination with multitude machine learning algorithms, basic classifiers like logistic regression advanced algorithms BERT. Tests total 171 models showed that, while intrinsically easier detect, no single encoders worked universally well all classes. For reason, we best individual each class generated CICERON (Classification bIoaCtive pEptides fRom micrObial fermeNtation), classification tool State-of-the-art found underperform our benchmark dataset compared included CICERON. Altogether, work provides real-world can serve future model development.
Language: Английский
Citations
6
Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3123 - 3123
Published: Sept. 10, 2024
Cancer remains one of the most difficult diseases to treat, requiring continuous research into innovative therapeutic strategies. Conventional treatments such as chemotherapy and radiotherapy are effective a certain extent but often have significant side effects carry risk resistance. In recent years, concept dual-acting therapeutics has attracted considerable attention, particularly combination DNA alkylating agents antimicrobial peptides. alkylation, well-known mechanism in cancer therapy, involves attachment alkyl groups DNA, leading damage subsequent cell death. Antimicrobial peptides, on other hand, been shown be anticancer due their ability selectively disrupt membranes modulate immune responses. This review aims explore synergistic potential these two modalities. It examines mechanisms action, current findings, promise they offer improve efficacy specificity treatments. By combining cytotoxic power alkylation with unique properties dual-action may new more approach fighting cancer.
Language: Английский
Citations
6
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Oct. 9, 2024
Antimicrobial peptides (AMPs), naturally occurring components of innate immunity, are emerging as a promising new class anticancer agents. This review explores the potential AMPs novel AMPs, with broad-spectrum antimicrobial activity, exhibit several characteristics that make them attractive candidates for cancer therapy, including selectivity cells, and immunomodulatory effects. Analysis dataset activity reveals their effectiveness is influenced by various structural properties, net charge, length, Boman index, hydrophobicity. These properties contribute to ability target disrupt cell membranes, interfere intracellular processes, modulate immune response. The highlights frontier in treatment, offering hope more effective less toxic therapies. demonstrate therapy through multiple mechanisms, direct cytotoxicity, response modulation, targeting tumor microenvironment, evidenced extensive preclinical studies animal models showing regression, metastasis inhibition, improved survival rates. show significant therapeutics microenvironment targeting, results from early-phase clinical trials. Future research should focus on optimizing AMP developing delivery strategies, exploring synergistic combination therapies fully realize treatments, while addressing challenges related stability, delivery, toxicity.
Language: Английский
Citations
4
Molecules, Journal Year: 2024, Volume and Issue: 30(1), P. 128 - 128
Published: Dec. 31, 2024
Multidrug-resistant (MDR) bacteria are becoming more and common, which presents a serious threat to world health could eventually render many of the antibiotics we currently use useless. The research development innovative antimicrobial tactics that can defeat these hardy infections imperative in light this predicament. Antimicrobial peptides (AMPs), have attracted lot attention due their distinct modes action capacity elude conventional resistance mechanisms, among most promising tactics. As substitute for antibiotics, AMPs varied class naturally occurring compounds target membranes disrupt cellular activities demonstrate broad-spectrum activity. objective study is present thorough summary current knowledge regarding AMP mechanisms against MDR bacteria, including immunological modulation, interactions with microbial membranes, possible synergy used drugs. In addition, define review’s scope include recent developments research, emphasizing innovations’ development, optimization, therapeutic promise. We hope emphasize crucial role will play future therapy by bringing together highlighting issues. also advocate AMPs’ continued as part comprehensive strategy counteract growing antibiotic resistance.
Language: Английский
Citations
4
Research in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 20(2), P. 165 - 187
Published: March 1, 2025
Despite great advances in cancer identification and treatment, malignancies remain the primary cause of high morbidity mortality worldwide. The drawbacks conventional chemotherapy, such as severe toxicity, lack specificity related to actively dividing cells, resistance, can warrant urgent need develop an alternative approach treat this disease. To overcome drawbacks, researchers are attempting deliver drugs site action (targeted delivery) or identify that specifically target tumor cells. In regard, highly cationic amphipathic antimicrobial peptides attracting attention due their potent anticancer activity, low cost manufacture, and, most critically, tumor-targeting activity. A growing number documents have shown some mentioned exhibited a broad spectrum cytotoxic activity against cells but not normal mammalian entitled peptides. Due solubility, strong penetration, selectivity, ability be used alone conjunction with other medications, potential become very successful treatments future. This review provided overview studies concerning peptide classification, modes action, also summarized developed for targeting different types malignancies. role silico methods artificial intelligence design discovery was briefly explained. Additionally, current addressed challenges utilizing therapy highlighted currently undergoing clinical trials.
Language: Английский
Citations
0
Toxins, Journal Year: 2025, Volume and Issue: 17(1), P. 32 - 32
Published: Jan. 10, 2025
The discovery of novel cytotoxic drugs is paramount importance in contemporary medical research, particularly the search for treatments with fewer side effects and higher specificity. Antimicrobial peptides are an interesting class molecules this endeavor. In context, LyeTx III, a new peptide extracted from venom Lycosa erythrognatha spider, stands out. exhibits typical antimicrobial traits: positive net charge amphipathic α -helix structure lipid-like environments. Its unique sequence (GKAMKAIAKFLGR-NH2), identified via mass spectrometry Edman degradation, shows limited similarity to existing peptides. Significantly, when liposome-encapsulated, III demonstrates selective activity against tumor cells culture. Our MTT results showed that cytotoxicity increased HN13 administered as liposomes, their viability alone being 98%, compared 38% liposome-encapsulated form. This finding underscores may be good candidate development cancer. encapsulated promising, it can increase its half-life body also targeted specific tumors.
Language: Английский
Citations
0
Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: 415, P. 111530 - 111530
Published: April 26, 2025
Language: Английский
Citations
0
Biologia, Journal Year: 2024, Volume and Issue: 79(8), P. 2515 - 2533
Published: July 1, 2024
Language: Английский
Citations
2
International Journal of Peptide Research and Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)
Published: Oct. 5, 2024
Language: Английский
Citations
0
ACS Omega, Journal Year: 2024, Volume and Issue: 9(45), P. 45402 - 45420
Published: Oct. 30, 2024
Melanoma, known for its aggressive metastatic potential, poses significant treatment challenges. Despite the potent antiproliferative effects of anticancer drugs, systemic toxicity and low water solubility limit their efficacy. This study addresses these challenges by employing magnetite (Fe3O4) nanobioconjugates as a drug delivery system, aimed at enhancing reducing off-target in melanoma therapy. Magnetite nanoparticles (MNPs) were engineered with functional molecules loaded agents Temozolomide (TMZ) or paclitaxel (PTX). The characterized via Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering (DLS), transmission electron microscopy (TEM). results validated efficacious synthesis loading, attaining efficiencies ranging from 32 to 72% TMZ 60% PTX. Biocompatibility assessments demonstrated excellent tolerance, minimal hemolysis rates platelet aggregation. In vitro studies revealed enhanced cytotoxicity against A-375 human cells compared free cellular uptake facilitated primarily through macropinocytosis, caveolin-, clathrin-mediated endocytosis. Furthermore, exhibited efficacy targeting spheroids, underlining potential research underscores promising avenue targeted treatment, offering specificity reduced oncological systems.
Language: Английский
Citations
0