Inactivation of Antibiotic Resistant Bacteria by Nitrogen-Doped Carbon Quantum Dots through Spontaneous Generation of Intracellular and Extracellular Reactive Oxygen Species DOI Creative Commons

Weibo Xia,

Zixia Wu,

Bingying Hou

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101428 - 101428

Published: Dec. 24, 2024

The widespread antibiotic resistance has called for alternative antimicrobial agents. Carbon nanomaterials, especially carbon quantum dots (CQDs), may be promising alternatives due to their desirable physicochemical properties and potential activity, but mechanism remains investigated. In this study, nitrogen-doped (N-CQDs) were synthesized inactivate antibiotic-resistant bacteria treat bacterial keratitis. N-CQDs via a facile hydrothermal approach displayed uniform particle size of less than 10 nm, featuring graphitic structure functional groups including -OH -NH2. demonstrated activity against Staphylococcus aureus (S. aureus) methicillin-resistant S. aureus, which was both dose- time-dependent, reducing the survival rate below 1 %. confirmed by live/dead staining. in vivo studies, more efficient treating drug-resistant keratitis corneal damage compared common levofloxacin. shown generate intracellular extracellular ROS, potentially caused oxidative stress, membrane disruption, cell death. This supported scanning transmission electron microscopy, significant regulation genes related increased protein lactate dehydrogenase leakage. study provided insight into development, application, applications.

Language: Английский

Insight into anti-corrosion mechanism of copper in 0.5 M sulfuric acid solution via microwave-assisted synthesis of carbon quantum dots as novel inhibitors DOI
Bochuan Tan, Yan Liu, Wenting Zhao

et al.

Sustainable materials and technologies, Journal Year: 2025, Volume and Issue: unknown, P. e01305 - e01305

Published: Feb. 1, 2025

Language: Английский

Citations

2
Tailored TiO2/WO3 Composites for Enhanced Electrocatalytic and Photocatalytic Applications DOI

Xinyang Xu,

Yingguan Xiao,

Ru‐Song Zhao

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Ultra‐Effective Light‐Activated Antibacterial Activity via Carboxyl Functionalized Graphene Quantum Dots and Films DOI Creative Commons
Muhammad Hassnain,

Laure S. van Hofwegen,

Hümeyra Nur Kaleli

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Bacterial infections are a major healthcare concern. Clinical application of photo‐activated quantum dots to efficiently treat bacterial has been hindered by inadequate production reactive oxygen species. In this study, photoactive antimicrobial carboxyl‐functionalized graphene (cGQDs) synthesized with an exceptionally high singlet ( 1 O 2 ) yield 0.88. Compared non‐functionalized GQDs, cGQDs exhibit over 20‐fold enhancement in the yield. According density functional theory simulations, dramatic increase is due significantly enhanced spin–orbit coupling between and triplet excited states GQDs addition ─COOH groups. Under low‐intensity blue light (5 mW cm − ), Staphylococcus aureus completely eliminated just 0.8 µg mL −1 cGQDs, minimum bactericidal concentration (MBC) 0.4 determined, representing lowest MBC reported against S. using light‐activated dots. Layer‐by‐layer assembly cGQD films also results 99.9% reduction multi‐drug resistant Escherichia coli under illumination. both suspension as nano‐assembled film, good cell viability mammalian cells dark conditions. These highlight strong potential effective nanomaterial for antibacterial applications.

Language: Английский

Citations

0
Advances in doped carbon quantum dots: synthesis, mechanisms, and applications in sensing technologies DOI

A.S. Sethulekshmi,

Asok Aparna,

Pradeep Parvathi

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163262 - 163262

Published: May 1, 2025

Language: Английский

Citations

0
Enhancing the quantum yield and electrochemical properties of carbon quantum dots via optimized hydrothermal treatment using cellulose nanocrystals as precursors DOI
Ruru Zhang, Ya Li, Feiyun Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137443 - 137443

Published: Nov. 8, 2024

Language: Английский

Citations

2
Large-Scale Synthesis of Carbon Dots Driven by Schiff Base Reaction at Room Temperature DOI Creative Commons

Ji-Fen Shi,

Shuai Chang,

Yating Gao

et al.

Inorganics, Journal Year: 2024, Volume and Issue: 12(12), P. 310 - 310

Published: Nov. 27, 2024

Photoluminescent carbon dots (CDs) have received increasing attention because of their admirable photophysical performances. The current strategies for synthesizing CDs typically require high energy consumption levels, and the ability to synthesize at ambient temperature would be highly desirable. Herein, we design an energy-efficient approach through a Schiff base crosslinking between 2,5-dihydroxy-1,4-benzoquinone tetraethylenepentamine room temperature. obtained possess maximum photoluminescence (PL) emissions 492 nm. Moreover, proposed good stability concentration-dependent PL can redshift from 621 nm as concentration increases. Because luminescent properties, employed optical probes doxorubicin detection using inner filter effect. This study develops powerful large-scale synthesis with superior performance.

Language: Английский

Citations

1
Biocompatible Carbon Dots/Polyurethane Composites as Potential Agents for Combating Bacterial Biofilms: N-Doped Carbon Quantum Dots/Polyurethane and Gamma Ray-Modified Graphene Quantum Dots/Polyurethane Composites DOI Creative Commons
Zoran Marković, Sladjana Dorontić, Svetlana Jovanović

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1565 - 1565

Published: Dec. 6, 2024

Background: Pathogen bacteria appear and survive on various surfaces made of steel or glass. The existence these in different forms causes significant problems healthcare facilities society. Therefore, the surface engineering highly potent antimicrobial coatings is important 21st century, a period that began with series epidemics. Methods: In this study, we prepared two types photodynamic polyurethane-based composite films encapsulated by N-doped carbon quantum dots graphene irradiated gamma rays at dose 50 kGy, respectively. Further, investigated their structural, optical, antibacterial, antibiofouling biocompatibility properties. Results: Nanoelectrical nanomechanical microscopy measurements revealed deviations structure polyurethane films. Young’s modulus elasticity was several times lower than for single-walled nanotubes (SWCNTs) chirality (6,5). electrical properties were quite similar to those SWCNTs much more elastic smoother dots. Antibacterial tests indicated excellent antibacterial activities against wide range tested bacteria, whereas both showed best results Staphylococcus aureus Escherichia coli biofilms. Biocompatibility studies neither film exhibited any cytotoxicity hemolysis. Conclusions: Obtained indicate could be used as facilities.

Language: Английский

Citations

1
Inactivation of Antibiotic Resistant Bacteria by Nitrogen-Doped Carbon Quantum Dots through Spontaneous Generation of Intracellular and Extracellular Reactive Oxygen Species DOI Creative Commons

Weibo Xia,

Zixia Wu,

Bingying Hou

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101428 - 101428

Published: Dec. 24, 2024

The widespread antibiotic resistance has called for alternative antimicrobial agents. Carbon nanomaterials, especially carbon quantum dots (CQDs), may be promising alternatives due to their desirable physicochemical properties and potential activity, but mechanism remains investigated. In this study, nitrogen-doped (N-CQDs) were synthesized inactivate antibiotic-resistant bacteria treat bacterial keratitis. N-CQDs via a facile hydrothermal approach displayed uniform particle size of less than 10 nm, featuring graphitic structure functional groups including -OH -NH2. demonstrated activity against Staphylococcus aureus (S. aureus) methicillin-resistant S. aureus, which was both dose- time-dependent, reducing the survival rate below 1 %. confirmed by live/dead staining. in vivo studies, more efficient treating drug-resistant keratitis corneal damage compared common levofloxacin. shown generate intracellular extracellular ROS, potentially caused oxidative stress, membrane disruption, cell death. This supported scanning transmission electron microscopy, significant regulation genes related increased protein lactate dehydrogenase leakage. study provided insight into development, application, applications.

Language: Английский

Citations

0