Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Modulation of collagen fibrillogenesis by varying the degrees chitosan deacetylation for preparation co-assembled biomimetic fibrils to enhance hemostasis.
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141570 - 141570
Published: Feb. 27, 2025
Language: Английский
Citations
4
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101292 - 101292
Published: Oct. 9, 2024
Chronic wounds are non-healing lesions characterized by a high degree of inflammation, posing significant challenges in clinical management due to the increased risk severe infection. This study focuses on developing powder for cutaneous application enhance healing and prevent infections chronic wounds. The smart nanocomposites-based biomimetic microparticles here developed combine properties chitosan clays represent innovation field biomaterials skin regeneration since they possess enhanced antimicrobial properties, multi-functional scaffolds promote cell proliferation, support tissue reconstruction mimicking natural extracellular matrix, provide hemostatic control bleeding during wound closure. were made doped with clay minerals, specifically montmorillonite or layered double hydroxides, containing copper ions. synergistic combination polymers aims regulate cellular responses, angiogenesis, matrix (ECM) deposition, leveraging bioactive both components healing. Montmorillonite hydroxides enriched ions through intercalation coprecipitation methods, respectively. water-insoluble prepared using derivative, carbamate, synthesized obtain chitosan-based via spray-drying without crosslinkers. Physico-chemical characterization confirmed successful doping Cu-clay interaction products microparticles. In addition proliferation presence Cu-clays boosted microparticles' antibacterial properties. Encouraging preclinical vitro vivo results suggest that these nanocomposite Cu-enriched minerals could be promising candidates simultaneously enhancing controlling
Language: Английский
Citations
4
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 355, P. 123362 - 123362
Published: Feb. 7, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1017 - 1017
Published: Feb. 22, 2025
Neurodegenerative disorders present significant therapeutic challenges, particularly due to the complex nature of drug delivery central nervous system. This review investigates applications various biopolymers in neuroprotection and their potential role treating neurodegeneration. We a critical analysis natural synthetic biopolymers, focusing primarily on chitosan, fish collagen/gelatin, alginate as key agents. The examines fundamental mechanisms brain development neurodegeneration, establishing framework for understanding how these interact with neural tissues. By analyzing recent experimental studies, we evaluate effectiveness different biopolymer-based systems crossing blood-brain barrier subsequent neuroprotective effects. Additionally, promising materials, including lignin, poly lactic-co-glycolic acid, glucose-modified bovine serum albumin/procyanidin complexes, are briefly explored provide comprehensive overview current developments field. Our reveals that approaches offer unique advantages both delivery, potentially opening new avenues neurodegenerative conditions. synthesizes knowledge identifies directions future research strategies.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141426 - 141426
Published: Feb. 1, 2025
Language: Английский
Citations
0
Biopolymers, Journal Year: 2025, Volume and Issue: 116(2)
Published: March 1, 2025
ABSTRACT This comprehensive review explores the potential of plant‐ and biopolymeric‐based antibacterials as innovative therapeutic agents for infectious skin wound healing. By researching antibacterial properties various plants, highlights their application in tissue engineering. Beyond reviewing plant extracts, article delves into limitations these natural compounds face, such hydrophilicity, drug release rates, cell attachment, scaffold stability when integrated engineering constructs. The also emphasizes role biopolymeric materials, hydrogel optimization, crosslinkers to improve performance. provides a roadmap future research by addressing critical factors construction. In end, it aims guide development more effective dressings scaffolds, combining power plants with advanced materials enhanced healing therapies.
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 234 - 234
Published: March 23, 2025
Interest in developing new, effective materials for emergency hemostasis and wound healing is steadily increasing, particularly use emergency, surgical, military situations. Hydrogels, with their unique retention, swelling, biocompatibility properties, have emerged as essential therapy. This review provides a comprehensive examination of recent hydrogel applications acute medical scenarios, including hemostasis, management, drug delivery, soft tissue replacement, engineering. We discuss the physicochemical properties that make hydrogels suitable rapid response situations, such tunable mechanical strength, adhesiveness, responsiveness to environmental stimuli, ability encapsulate release therapeutic agents. Additionally, article explores advancements smart self-healing antimicrobial providing insights into potential revolutionize care increase survival rates both civilian applications. Through critical evaluation current clinical trials practical deployments, this highlights successes challenges faced integrating protocols, roadmap future research development dynamic field.
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 584 - 584
Published: April 16, 2025
Background/Objectives: The safe completion of a non-invasive procedure is crucial to the success an endovascular approach. Chitosan, natural polysaccharide derived from chitin, ideal material for study and application medical devices in post-operative wound management. Methods: present work based on retrospective conducted sample patients treated with Axiostat (a sterile, single-use, non-absorbable dressing), composed 100% chitosan designed instantly stop bleeding through mucus adhesion mechanism treatment conditions such as Leriche’s syndrome. objective was evaluate efficacy safety hemostatic dressing undergoing anticoagulant and/or antiplatelet therapy whom procedures using axillary artery access site are performed treat Leriche Results: obtained results showed that effective promoting hemostasis at vascular even when prolonged required therapy. mean time 5.75 min all types considered.
Language: Английский
Citations
0
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123656 - 123656
Published: April 1, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135987 - 135987
Published: Sept. 24, 2024
Language: Английский
Citations
3