Advancing wound healing by hydrogel-based dressings loaded with cell-conditioned medium: a systematic review
Galina Nifontova,
No information about this author
Sofia Safaryan,
No information about this author
Yana Khristidis
No information about this author
et al.
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 17, 2024
Wound
healing
represents
a
complex
biological
process,
critically
important
in
clinical
practice
due
to
its
direct
implication
patient's
recovery
and
quality
of
life.
Conservative
wound
management
frequently
falls
short
providing
an
ideal
environment
for
the
optimal
tissue
regeneration,
often
resulting
extended
periods
elevated
risk
infection
other
complications.
The
emerging
biomaterials,
particularly
hydrogels,
have
shown
substantial
promise
addressing
these
challenges
by
offering
properties
such
as
biocompatibility,
biodegradability,
ability
cure
environment.
Recent
advancements
highlighted
therapeutic
potential
integrating
cell-derived
conditioned
medium
(CM)
into
hydrogel
matrices.
Cell-derived
CM
rich
array
bioactive
molecules,
demonstrating
significant
efficacy
modulating
cellular
activities
crucial
healing,
including
proliferation,
migration,
angiogenesis.
Language: Английский
The Potential Application of AZ31-Mg(OH)2/CeO2 as Temporary Medical Implants: Evaluation of the Corrosion Resistance and Biocompatibility Properties
Coatings,
Journal Year:
2025,
Volume and Issue:
15(4), P. 450 - 450
Published: April 10, 2025
Magnesium-based
alloys
are
considered
to
be
promising
materials
for
the
fabrication
of
temporary
bone
repair
medical
implants.
The
AZ31
magnesium-based
(AZ31-Mg)
alloy
contains
3%
aluminum
and
1%
zinc
in
its
microstructure,
which
gives
it
mechanical
strength
corrosion
resistance.
Nonetheless,
rate
is
high,
can
lead
implant
failure
due
rapid
degradation,
triggers
release
harmful
metal
ions.
In
present
work,
a
passive
layer
was
obtained
on
AZ31-Mg
alloy,
subsequently,
cerium
oxide
(CeO2)
coating
deposited
through
chemical
conversion
treatment
using
0.01
M
CeO2
as
precursor.
Based
X-ray
photoelectron
spectroscopy,
calculated
amount
Ce(IV)
Ce(III)
AZ31-Mg(OH)2/CeO2
93.6%
6.4%,
respectively.
showed
improved
resistance
compared
with
bare
sample.
vitro
assessment
MC3T3-E1
pre-osteoblast
cell
viability
that
biocompatible
after
incubation
24
72
h.
results
revealed
confers
greater
electrochemical
stability
biocompatibility
properties,
mostly
presence
Ce4+
Language: Английский
Fabrication of polydopamine-altered PCL/PLGA nanofibrous scaffolds on cerium to enhance cytocompatibility, microbial inhibition, and improved osteogenic properties for tissue regeneration in orofacial treatment
Chong Luo,
No information about this author
Cheng Kang,
No information about this author
Shi Qiu
No information about this author
et al.
Biochemical and Biophysical Research Communications,
Journal Year:
2025,
Volume and Issue:
766, P. 151852 - 151852
Published: April 18, 2025
Language: Английский
Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
Macromolecular Materials and Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 14, 2025
Abstract
In
recent
times,
the
integration
of
nanomaterials
into
3D
biofabricated
structures
has
become
a
transformative
approach
in
advancing
biomedical
field.
Nanomaterials
exhibit
distinctive
properties
such
as
superior
mechanical
strength,
enhanced
biocompatibility,
and
improved
drug
delivery
efficiency,
making
them
well‐suited
for
use.
This
comprehensive
review
explores
synergistic
potential
combining
nanomaterials—such
metallic,
carbon‐based,
ceramic,
polymeric
nanoparticles—with
advanced
biofabrication
techniques,
including
bioprinting,
melt
electrowriting,
electrospinning.
These
integrations
have
demonstrated
significant
promise
diverse
applications,
regeneration
nerve,
bone,
cardiac
tissues,
wound
healing,
cancer
therapy.
Despite
substantial
progress,
several
challenges
hinder
clinical
translation,
difficulties
achieving
precise
nanomaterial
integration,
biocompatibility
toxicity
concerns,
scalability
manufacturing,
regulatory
complexities.
synthesizes
advancements,
evaluates
existing
challenges,
identifies
key
research
directions
to
address
these
obstacles.
It
highlights
significance
interdisciplinary
collaboration
maximizing
nanomaterial‐integrated
promoting
innovative
advancements
science
healthcare.
Language: Английский
Electrospinning Technologies for Biomedical and Biotechnological Applications
Technologies,
Journal Year:
2024,
Volume and Issue:
12(10), P. 173 - 173
Published: Sept. 25, 2024
Electrospinning
is
a
highly
versatile
and
powerful
technique
that
has
transformed
the
field
of
nanotechnology
[...]
Language: Английский