A Self-Gelling Powder Based on Polyacrylic Acid/Polyethyleneimine/Polyethylene Glycol for High-Performance Hemostasis and Antibacterial Activity DOI Open Access
Jia Li, Shu Li,

Aozhen Zhong

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3516 - 3516

Published: Dec. 18, 2024

Powder-based hemostatic materials have offered unprecedented opportunities for the effective sealing and repair of irregularly shaped wounds high-pressure, noncompressible arterial bleeding caused by surgeries, traffic accidents, wartime injuries. However, inadequate adhesion to poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling powder based on polyacrylic acid/polyethyleneimine/polyethylene glycol (named PPG) rapid antibacterial ability. When deposited wounds, PPG can absorb interfacial liquid rapidly swell into physically cross-linked hydrogel situ within 2 s form pressure-resistant physical barrier. Furthermore, vivo vitro results indicate that, as an sealant, possesses ease use, excellent hemocompatibility, strong abilities, superior blood clotting abilities. The capability is demonstrated variety injury models rats rabbits. All these factors show with its wound treatment profound biomaterial surgical applications.

Language: Английский

A highly compressible and expandable cellulose sponge with arch-like lamellar structures for non-compressible hemorrhage DOI

Bei Cai,

Yawen Fan,

Shuo Yang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123255 - 123255

Published: Jan. 11, 2025

Language: Английский

Citations

2
In Situ Sprayed Self‐Gelling Powder Self‐Assembled by a Pure Molecular Drug from Herbal Extract for Rapid Hemostasis and Neuroprotection in Traumatic Brain Injury DOI Open Access
Teng Li, Jun Zheng,

Mingyue Xia

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Immediate hemostasis and effective treatment are foremost for acute intervention in traumatic brain injury (TBI), but the therapeutic tools professional methods often lacking at scene. Self‐gelling powders formed by self‐assembly of pure molecular drugs can quickly deliver hemostatic effects without complications from chemical modifications or additional carriers. However, no clinical have been reported as a self‐gelling powder this purpose. Here, is self‐assembled sodium aescinate (SA), drug already approved treating trauma. To generate SA (SA self‐gel‐P), heated cooled an alkaline solution to form hydrogel, then freeze‐dried ground. The obtained self‐gel‐P has good hydrophilicity. When sprayed onto bleeding site after TBI, it rapidly absorbed blood gel through intermolecular hydrogen bonding, facilitating situ sealing rapid hemostasis. Furthermore, hydrogel released over long period, which helped reduce neuronal death, improve integrity blood‐brain barrier, edema, alleviate neuroinflammation, ultimately promote recovery neurofunction significant toxic side effects. This may serve powerful auxiliary tool pre‐hospital TBI.

Language: Английский

Citations

0
Iron-based driven chitosan quaternary ammonium salt self-gelling powder: Sealing uncontrollable bleeding and promoting wound healing DOI

Xiaolong Hu,

Hongyan Zhang, Hao Cheng

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140330 - 140330

Published: Jan. 1, 2025

Language: Английский

Citations

0
Recent Trends in the Application of Cellulose-Based Hemostatic and Wound Healing Dressings DOI Creative Commons
Bukatuka Futila Clemence,

Bricard Mbituyimana,

Lin Xiao

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 151 - 151

Published: April 23, 2025

Rapid hemostasis and wound healing are crucial severe trauma treatment. Natural mechanisms often prove insufficient, spurring research for innovative biomaterials. This review focuses on cellulose-based materials, which promising due to their absorbency, biocompatibility, processability. The novelty lies in exploring how these materials promote clotting tissue regeneration. They operate via extrinsic intrinsic mechanisms. Extrinsically, they create a matrix at the activate coagulation; intrinsically, maintain factors. Additionally, aid through physical, chemical, biological means, such as maintaining moisture, incorporating antimicrobial agents, stimulating cell activity. fabrication strategies include material selection chemical modification. Techniques like oxidation enhance performance. Structural engineering methods freeze-drying 3D printing optimize porosity alignment. Cellulose-based dressings versatile effective various forms. address different needs show benefits rapid coagulation repair. also covers challenges future trends, emphasizing need mechanical properties biodegradability. Further, new technologies offer potential improvements nanocomposites. Overall, continued dressing is vital, unlocking could revolutionize care, providing suitable solutions management.

Language: Английский

Citations

0
The gelatin sponge loaded with curcumin coating exhibits a synergistic effect of hemostasis, anti-inflammatory, and anti-scarring DOI
Xiaoxue Tan, Hongzhong Xi,

Peng Xue

et al.

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 169, P. 214155 - 214155

Published: Dec. 20, 2024

Language: Английский

Citations

1
A Self-Gelling Powder Based on Polyacrylic Acid/Polyethyleneimine/Polyethylene Glycol for High-Performance Hemostasis and Antibacterial Activity DOI Open Access
Jia Li, Shu Li,

Aozhen Zhong

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3516 - 3516

Published: Dec. 18, 2024

Powder-based hemostatic materials have offered unprecedented opportunities for the effective sealing and repair of irregularly shaped wounds high-pressure, noncompressible arterial bleeding caused by surgeries, traffic accidents, wartime injuries. However, inadequate adhesion to poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling powder based on polyacrylic acid/polyethyleneimine/polyethylene glycol (named PPG) rapid antibacterial ability. When deposited wounds, PPG can absorb interfacial liquid rapidly swell into physically cross-linked hydrogel situ within 2 s form pressure-resistant physical barrier. Furthermore, vivo vitro results indicate that, as an sealant, possesses ease use, excellent hemocompatibility, strong abilities, superior blood clotting abilities. The capability is demonstrated variety injury models rats rabbits. All these factors show with its wound treatment profound biomaterial surgical applications.

Language: Английский

Citations

0