Coassembly of Charged Copolymer Amphiphiles Featuring pH-Regulated Antifouling Properties DOI
Arnab Banerjee, Kunal Arya, Mark F. Davis

et al.

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Understanding the formation of highly ordered structures through self-assembly is crucial for developing various biologically relevant systems. A significant expansion in development chemistry features stable coassembly using a mixture two oppositely charged polymers. This study provides insightful findings on hydrophobic coumarin-integrated cationic (P1–P3) and anionic (P1′–P3′) copolymers toward vesicles aqueous medium at pH 7.4, with hydrodynamic diameter (Dh) 160 ± 10 nm electrically neutral zwitterionic surfaces, confirmed by dynamic light scattering. Upon varying solution pH, an intriguing charge switchable behavior (+ve → 0 −ve) drastic morphological transition to spherical aggregates were noticed. At these coassembled possess surface charge, empowering them resist nonspecific protein (pepsin lysozyme) adsorption via electrostatic repulsion, as evidenced size evolution binding measurements. Additionally, bilayer membrane allows encapsulation hydrophilic guest molecules their sustained release presence mM esterase; thus, this demonstrates potential applications serve drug delivery vehicle.

Language: Английский

Nanoparticles, a promising treatment for gastric cancer DOI Creative Commons
Hua Dong, Xiexing Wu,

Zebin Wu

et al.

Smart Materials in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Coassembly of Charged Copolymer Amphiphiles Featuring pH-Regulated Antifouling Properties DOI
Arnab Banerjee, Kunal Arya, Mark F. Davis

et al.

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Understanding the formation of highly ordered structures through self-assembly is crucial for developing various biologically relevant systems. A significant expansion in development chemistry features stable coassembly using a mixture two oppositely charged polymers. This study provides insightful findings on hydrophobic coumarin-integrated cationic (P1–P3) and anionic (P1′–P3′) copolymers toward vesicles aqueous medium at pH 7.4, with hydrodynamic diameter (Dh) 160 ± 10 nm electrically neutral zwitterionic surfaces, confirmed by dynamic light scattering. Upon varying solution pH, an intriguing charge switchable behavior (+ve → 0 −ve) drastic morphological transition to spherical aggregates were noticed. At these coassembled possess surface charge, empowering them resist nonspecific protein (pepsin lysozyme) adsorption via electrostatic repulsion, as evidenced size evolution binding measurements. Additionally, bilayer membrane allows encapsulation hydrophilic guest molecules their sustained release presence mM esterase; thus, this demonstrates potential applications serve drug delivery vehicle.

Language: Английский

Citations

1