Fabrication and Evaluation of Dissolving Hyaluronic Acid Microneedle Patches for Minimally Invasive Transdermal Drug Delivery by Nanoimprinting

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 89 - 89

Published: Jan. 23, 2025

Transdermal drug delivery minimizes pain and provides a controlled, stable release of drugs, but its effectiveness is limited by the skin’s natural barriers. Microneedles overcome this problem, enabling minimally invasive delivery. Microneedle patches (MNPs) with 80 µm-tall needles composed hyaluronic acid (HA) were developed evaluated for their formability, structural integrity, dissolution rate, skin penetration ability, transmission capacity. The influence molecular weight HA on these properties was also investigated. MNPs made from low-molecular-weight (30 kDa–50 kDa) demonstrated 12.5 times superior permeability in ex vivo human compared to needleless (NLPs). Furthermore, same test, had 1.7 higher than high-molecular-weight MNPs, suggesting transdermal administration. significantly influenced solubility permeability, highlighting potential as systems. Puncture tests depth 50–60 µm, indicating minimal nerve irritation dermis effective superficial dermal layer. These results present manufacturing technique incorporating model compounds highlight novel method biomedical applications soft gels.

Language: Английский

Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 206 - 206

Published: March 15, 2025

Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.

Language: Английский

Development of Polylactic Acid Microneedles for Enhanced Transdermal Delivery of Desmopressin Peptides: A Computational Study

Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 103777 - 103777

Published: April 1, 2025

Language: Английский