Mucoadhesive Polymeric Film with Plant-Based Compounds for Dental Applications: Formulation, Characterization and Evaluation

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: April 28, 2025

Polymeric films are promising formulations for oromucosal drug delivery, particularly localized treatment of dental diseases. This study focused on developing mucoadhesive applications, incorporating clove CO2 extract and essential oils lavender grapefruit as active ingredients. The were prepared using the solvent casting method, with various film-forming agents (sodium alginate, sodium carboxymethyl cellulose, hydroxyethyl hydroxypropyl polyvinyl alcohol) used individually in combinations, without or plasticizers (glycerol, polyethylene glycol 400, their mixtures). To optimize selection polymer plasticizer, properties such appearance, thickness, pH, moisture content, bursting strength, tensile capacity, elasticity, dissolution, adhesion, evaluated. combination cellulose 400 was proved most suitable, ensuring superior organoleptic, physicochemical, textural characteristics. demonstrated strong mucoadhesion (9.20 ± 0.58 N), contributing prolonged retention mucosa enhanced bioavailability In vitro release studies showed sustained profile, approximately 90% eugenol released during final film dissolution phase (360-420 min), supporting therapeutic effects local therapy efficacy. also exhibited significant antimicrobial activity against a broad spectrum microorganisms, confirming potential treating infectious inflammatory oral

Language: Английский

EVALUATION OF THE EFFECT OF THE MUCOPROTECTIVE SPRAY ON PERIODONTAL INFLAMMATION: RHEOLOGICAL PARAMETERS OF MIXED SALIVA

The actual problems in dentistry, Journal Year: 2024, Volume and Issue: 20(3), P. 67 - 71

Published: Oct. 31, 2024

Subject. The subject of the study is a mucoprotective spray, mixed saliva. Objectives. aim was to evaluate effectiveness use mucorotective spray on periodontal inflammation by analyzing dynamic changes in rheological properties Methodology. conducted Department Therapeutic Dentistry and Propaedeutics Dental Diseases, General Chemistry, Ural State Medical University. research objects are: 1 – with mucoprotector, titanium glycerosolvate aquacomplex used as an “inorganic nanoparticle” high delivery capabilites into deep tissue layers activity enhancement anti–inflammatory, antimicrobial regenerating components spray; 2 without aquacomple (aqueous solution), placebo. involved 30 dental volunteer students whose average age 20.5 ± 0.95 years (12 young men, 18 women) inflammation. Two groups were formed consisting 15 people each who sprays during two weeks. parameters saliva determined following methods: measuring salivary flow rates, viscosity measurements, evaluation surface tension characterize its rinsing function cleansing properties. Conclusions. Analysis findings shows basis anti-inflammatory effect, that confirmed hygiene index PMA (p ⩽ 0.05). has got trans-mucus penetration good tolerability; it easy economically affordable. analysis patients from first group application course mucoprotector showed increased rates decreased These enhance propertiies saliva, properties, well reduce risk tooth decay gum swelling, prevent deposits

Language: Английский