Development of Ofloxacin-Loaded CS/PVA Hydrogel for the Treatment of Metritis in Bovine DOI Creative Commons
Priyanka Kumari, Manish Shukla,

Ashutosh Tripathi

et al.

Drugs and Drug Candidates, Journal Year: 2025, Volume and Issue: 4(2), P. 17 - 17

Published: April 16, 2025

Background: Metritis, a common postpartum uterine infection in bovines, poses substantial challenges livestock management, including compromised fertility and economic losses. Poor drug penetration systemic side effects, necessitating innovative localised delivery systems limiting current antibiotic treatments. Aim: This study aimed to develop evaluate the potential effect of ofloxacin-loaded hydrogel as system treat metritis bovine. The focus was on achieving sustained release, enhanced antibacterial efficacy reduced inflammation endometrium. Materials Methods: CS/PVA synthesised using freeze–thaw method further optimised for encapsulation efficiency (96.7 ± 2.1%), stability biocompatibility. Physicochemical characterisation included swelling behaviour, mechanical properties rheological analysis. In vitro release profiles simulated fluid were assessed over 72 h activity tested against pathogens such Escherichia coli S. aureus. vivo studies conducted bovines diagnosed with endometritis clinical recovery. Results: SEM image resulted smooth porous structure demonstrating larger pore size than blank. suggested higher elastic behaviour. Antibacterial assays E. aureus revealed significant inhibition zones, respectively, indicating potent efficacy. vivo, evaluated treated bovine, bacterial loads exhibited (2.86 × 105A CFU/mL → 6.37 102B CFU/mL), improvement marked resolved. Conclusions: Ofloxacin-loaded hydrogels represent promising treatment bovine metritis, offering action improved outcomes. approach addresses limitations therapies provides practical solution veterinary care. Further are recommended validate these findings more extensive field trials explore commercialisation potential.

Language: Английский

Development the Hydrophobic Property of Polyvinyl Alcohol/Silicon Dioxide/Titanium Dioxide Nanocomposites for Self-Cleaning and Soil Stabilization DOI Creative Commons
Rania F. Khedr, M. A. Elhady

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1664 - 1664

Published: April 8, 2025

This study focused on synthesizing polyvinyl alcohol (PVA) utilizing glutaraldehyde (GA) as a crosslinking agent and silicon dioxide (SiO2) nanopowder with titanium (TiO2) to reduce or prevent the hydrophilic property of PVA. Integrating SiO2 TiO2 into PVA boosted hydrophobicity, thermal properties, self-cleaning film. The characteristic properties PVA/GA, PVA/SiO2/GA, PVA/SiO2/TiO2/GA nanocomposites polymer membranes were investigated by gel content, swelling capacity, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction patterns (XRD), scanning electron microscope (SEM), gravimetric analysis (TGA), contact angle. resulting PVA/5%SiO2/1%TiO2/GA nanocomposite exhibits much better physical than PVA/GA hydrogel (water absorbency from 3.1 g/g 0.07 angel 0° 125°). In addition, retains very low properties. These prepared are promising in variety applications such sand soil stabilizers, construction, building works where they exhibit excellent water resistance performance. introduces novel approach for creating hydrophobic polymeric materials stabilize sandy effectively.

Language: Английский

Citations

0
Polyvinyl alcohol/casein hydrogels with oxymatrine eluting ability for cancer-related wound management DOI

Pedro Rainho,

Madalena Salema‐Oom, Carlos A. Pinto

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Polyvinyl alcohol/casein hydrogels for oxymatrine delivery in malignant fungating wounds were developed. Dressings produced by cast drying using genipin as crosslinker showed the best release profile and maintained optimal properties.

Language: Английский

Citations

0
SDS enhanced Graphene Dispersion in PVA Matrix: Structural, Mechanical, and Conductivity Implications DOI Open Access

Lekshmi Omana,

Anoop Chandran,

Reshma Pi

et al.

Journal of Physics Conference Series, Journal Year: 2025, Volume and Issue: 2995(1), P. 012013 - 012013

Published: April 1, 2025

Abstract This study explores the effect of sodium dodecyl sulphate (SDS) on graphene dispersion in polyvinyl alcohol (PVA) and its impact mechanical, electrical, structural properties PVA/graphene nanocomposites. FTIR confirmed strong interactions between graphene, PVA, SDS. Mechanical testing revealed significant improvements tensile strength flexibility at optimal SDS concentration. Electrical conductivity increased notably with higher levels, highlighting effectiveness SDS-assisted dispersion. offers valuable insights into role shaping developed nanocomposites, which exhibit unique characteristics that make them suitable for flexible electronics applications.

Language: Английский

Citations

0
Emerging biofouling control strategies in MBR systems: Quorum quenching, electrochemical methods, and mechanically imposed membrane shear DOI
Roent Dune A. Cayetano, Sungwoo Bae, Hyun‐Suk Oh

et al.

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 73, P. 107684 - 107684

Published: April 14, 2025

Language: Английский

Citations

0
Development of Ofloxacin-Loaded CS/PVA Hydrogel for the Treatment of Metritis in Bovine DOI Creative Commons
Priyanka Kumari, Manish Shukla,

Ashutosh Tripathi

et al.

Drugs and Drug Candidates, Journal Year: 2025, Volume and Issue: 4(2), P. 17 - 17

Published: April 16, 2025

Background: Metritis, a common postpartum uterine infection in bovines, poses substantial challenges livestock management, including compromised fertility and economic losses. Poor drug penetration systemic side effects, necessitating innovative localised delivery systems limiting current antibiotic treatments. Aim: This study aimed to develop evaluate the potential effect of ofloxacin-loaded hydrogel as system treat metritis bovine. The focus was on achieving sustained release, enhanced antibacterial efficacy reduced inflammation endometrium. Materials Methods: CS/PVA synthesised using freeze–thaw method further optimised for encapsulation efficiency (96.7 ± 2.1%), stability biocompatibility. Physicochemical characterisation included swelling behaviour, mechanical properties rheological analysis. In vitro release profiles simulated fluid were assessed over 72 h activity tested against pathogens such Escherichia coli S. aureus. vivo studies conducted bovines diagnosed with endometritis clinical recovery. Results: SEM image resulted smooth porous structure demonstrating larger pore size than blank. suggested higher elastic behaviour. Antibacterial assays E. aureus revealed significant inhibition zones, respectively, indicating potent efficacy. vivo, evaluated treated bovine, bacterial loads exhibited (2.86 × 105A CFU/mL → 6.37 102B CFU/mL), improvement marked resolved. Conclusions: Ofloxacin-loaded hydrogels represent promising treatment bovine metritis, offering action improved outcomes. approach addresses limitations therapies provides practical solution veterinary care. Further are recommended validate these findings more extensive field trials explore commercialisation potential.

Language: Английский

Citations

0