Aberrances of the Wound Healing Process: A Review DOI Creative Commons
M. Fernández‐Guarino, Jorge Naharro‐Rodríguez, Stefano Bacci

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 209 - 209

Published: Nov. 28, 2024

Wound healing is a complex biological process that can lead to chronic wounds, keloids, and hypertrophic scars when disrupted. Chronic wounds result from prolonged inflammatory phase impaired re-epithelialization. Keloids are characterized by excessive collagen deposition beyond the original wound boundaries, driven persistent inflammation fibroblast hyperactivity. Hypertrophic scars, on other hand, confined edges caused an imbalance in synthesis degradation, typically resolving over time. The therapeutic approach impairment involves range of strategies, including non-invasive (which focus supporting natural process), minimally invasive, aggressive interventions (such as surgical approach, often reserved for severe or refractory cases). Emerging therapies, stem cell treatments botulinum toxin injections, offer new hope improving outcomes patients with impairments. This review highlights distinct mechanisms underlying discusses their respective approaches, focusing both established emerging therapies. Understanding these crucial optimizing treatment strategies patient outcomes.

Language: Английский

New Perspectives of Hydrogels in Chronic Wound Management DOI Creative Commons

A. S. Alberts,

Ana‐Maria Bratu, Adelina-Gabriela Niculescu

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 686 - 686

Published: Feb. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Language: Английский

Citations

5
Naturally derived hydrogels for wound healing DOI
Duy Toàn Phạm, Nguyễn Thị Thủy, Nguyễn Thị Phương Thảo

et al.

Therapeutic Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 27, 2025

Natural hydrogels have garnered increasing attention due to their natural origins and beneficial roles in wound healing. Hydrogel water-retaining capacity excellent biocompatibility create an ideal moist environment for healing, thereby enhancing cell proliferation tissue regeneration. For this reason, naturally derived formulated from biomaterials such as chitosan, alginate, gelatin, fibroin are highly promising biodegradability low immunogenic responses. Recent integrated approaches utilizing new technologies with bioactive agents significantly improved the mechanical properties of controlled release delivery active compounds, efficiency treatment processes. Herein, review highlights advantages challenges focusing on strength, degradation rates, safety validation, potential incorporating advanced engineering gene therapy utilization personalized medicine.

Language: Английский

Citations

1
Advanced Hydrogel Systems for Local Anesthetic Delivery: Toward Prolonged and Targeted Pain Relief DOI Creative Commons

Jin-Oh Jeong,

Min-Joo Kim,

Seonwook Kim

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 131 - 131

Published: Feb. 12, 2025

Local anesthetics (LAs) have been indispensable in clinical pain management, yet their limitations, such as short duration of action and systemic toxicity, necessitate improved delivery strategies. Hydrogels, with biocompatibility, tunable properties, ability to modulate drug release, extensively explored platforms for enhancing LA efficacy safety. This narrative review explores the historical development LAs, physicochemical applications, providing a foundation understanding integration hydrogels anesthetic delivery. Advances thermoresponsive, stimuli-responsive, multifunctional demonstrated significant potential prolonging analgesia reducing exposure preclinical studies, while early findings highlight feasibility thermoresponsive hydrogel formulations. Despite these advancements, challenges burst mechanical instability, regulatory considerations remain critical barriers translation. Emerging innovations, including nanocomposite hydrogels, biofunctionalized matrices, smart materials, offer solutions limitations. Future research should focus on optimizing formulations, expanding validation, integrating advanced fabrication technologies 3D printing artificial intelligence-driven design enhance personalized management. By bridging materials science pharmacology, this provides comprehensive perspective current trends future directions hydrogel-based systems.

Language: Английский

Citations

0
The landscape of biofilm models for phage therapy: mimicking biofilms in diabetic foot ulcers using 3D models DOI Creative Commons
Mark Grevsen Martinet, Marvin L. Thomas,

Jörg Bojunga

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Diabetic foot ulcers (DFU) affect up to 15-25% of patients suffering from diabetes and are considered a global health concern. These may result in delayed wound healing chronic infections, with the potential lead amputations. It has been estimated that 85% diabetes-related amputations preceded by diagnosis DFU. A critical factor persistence this disease is presence polymicrobial biofilms, which generally include Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli. The involvement diabetic comorbidities such as ischemia, hyperglycemia, immune-compromised status creates perfect niche for these bacteria evade body's immune response persist biofilms. Bacteriophage therapy can target lyse specific emerging an effective treatment biofilm-related infections. While shows promise addressing wounds, our current models, including animal static systems, fail capture full complexity Innovative approaches 3D bioengineered skin organoid hydrogel-based systems being developed simulate DFU microenvironments more accurately without using ex vivo or tissues. advanced models evaluating bacteriophage efficacy biofilm-associated DFU, aiming enhance preclinical assessments improve therapeutic outcomes patients.

Language: Английский

Citations

0
Wound Healing in Human Skin Equivalents Reconstructed with Biopolymers Under Fine-Dust Exposure DOI Open Access
T. Kim, Junwoo Lim, Jae Hyun Jeong

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 901 - 901

Published: March 27, 2025

Airborne fine-dust pollution poses a significant threat to both respiratory and skin health; however, the skin's wound-healing process in response such exposure remains underexplored. Therefore, this study examined effect of fine-dust-model compounds, specifically polycyclic aromatic hydrocarbons (PM10-PAHs) trace-metal-containing particles (PM10-Trace), on using human equivalents reconstructed with collagen-based biomaterials cells. Our findings revealed that significantly delayed wound closure by 2-3 times compared unexposed controls, impairing re-epithelialization. Live imaging dynamics had more pronounced inhibitory than hydrocarbons. Furthermore, elevated protease-activated receptor-1 (PAR1) expression up 161%, indicating physiological disruption. Additionally, triggered inflammation oxidative stress, leading structural functional damage skin. These results provide critical insights into how airborne pollutants disrupt repair mechanisms highlight need for targeted strategies mitigate their harmful effects.

Language: Английский

Citations

0
Peptides and peptidomimetics in the development ofhydrogels towards the treatment of diabetic wounds DOI Creative Commons
Ana Gomes, Paula Gomes

Current Research in Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 100292 - 100292

Published: April 1, 2025

Language: Английский

Citations

0
Rational design of site-specific artificial metallonucleases for therapeutic applications DOI Creative Commons
Xixi Lu, Chengchen Zhang

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113736 - 113736

Published: April 1, 2025

Language: Английский

Citations

0
Aberrances of the Wound Healing Process: A Review DOI Creative Commons
M. Fernández‐Guarino, Jorge Naharro‐Rodríguez, Stefano Bacci

et al.

Cosmetics, Journal Year: 2024, Volume and Issue: 11(6), P. 209 - 209

Published: Nov. 28, 2024

Wound healing is a complex biological process that can lead to chronic wounds, keloids, and hypertrophic scars when disrupted. Chronic wounds result from prolonged inflammatory phase impaired re-epithelialization. Keloids are characterized by excessive collagen deposition beyond the original wound boundaries, driven persistent inflammation fibroblast hyperactivity. Hypertrophic scars, on other hand, confined edges caused an imbalance in synthesis degradation, typically resolving over time. The therapeutic approach impairment involves range of strategies, including non-invasive (which focus supporting natural process), minimally invasive, aggressive interventions (such as surgical approach, often reserved for severe or refractory cases). Emerging therapies, stem cell treatments botulinum toxin injections, offer new hope improving outcomes patients with impairments. This review highlights distinct mechanisms underlying discusses their respective approaches, focusing both established emerging therapies. Understanding these crucial optimizing treatment strategies patient outcomes.

Language: Английский

Citations

0