Morphology Design and Precision Control of Microneedles by PμSL 3D Printing DOI Open Access
Baoling Jia,

Tiandong Xia,

Yangtao Xu

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(10), P. 1351 - 1351

Published: May 15, 2025

Microneedles (MNs) hold significant potential for applications in transdermal drug delivery and biosensing. However, when traditional 3D printing technology is used their manufacture, a substantial deviation output size occurs. The effects of various parameters on the morphology MNs produced through microscale remain unclear. This study investigated relationship between design fabrication acrylic resin forms via projection microstereolithography (PµSL) system. Modifying shape array configurations elucidates causes proposes control strategy. particularly prototyping mold manufacturing relevant fields. indicates that layer thickness 10 µm optimally balances efficiency clinical conversion requirements. Additionally, an exposure intensity 65 mW/cm2 achieves both high fidelity appropriate base size. angle significantly influences mechanical properties MNs. diameter aspect ratio solid correlate with dimensional stability. Clinically, conical or quadrilateral defined are recommended. A critical spacing (≥40 µm) optimal arrangement MN arrays were established. specific vertical hollow ensure precision micropore wall thickness. approach offers theoretical insights process essential high-precision, customizable engineering design.

Language: Английский

Morphology Design and Precision Control of Microneedles by PμSL 3D Printing DOI Open Access
Baoling Jia,

Tiandong Xia,

Yangtao Xu

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(10), P. 1351 - 1351

Published: May 15, 2025

Microneedles (MNs) hold significant potential for applications in transdermal drug delivery and biosensing. However, when traditional 3D printing technology is used their manufacture, a substantial deviation output size occurs. The effects of various parameters on the morphology MNs produced through microscale remain unclear. This study investigated relationship between design fabrication acrylic resin forms via projection microstereolithography (PµSL) system. Modifying shape array configurations elucidates causes proposes control strategy. particularly prototyping mold manufacturing relevant fields. indicates that layer thickness 10 µm optimally balances efficiency clinical conversion requirements. Additionally, an exposure intensity 65 mW/cm2 achieves both high fidelity appropriate base size. angle significantly influences mechanical properties MNs. diameter aspect ratio solid correlate with dimensional stability. Clinically, conical or quadrilateral defined are recommended. A critical spacing (≥40 µm) optimal arrangement MN arrays were established. specific vertical hollow ensure precision micropore wall thickness. approach offers theoretical insights process essential high-precision, customizable engineering design.

Language: Английский

Citations

0