Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2802 - 2802
Published: Sept. 21, 2023
This Special Issue of Processes, entitled “Synthesis, Application, and Biological Evaluation Chemical Organic Compounds”, gathers the most recent work leading researchers in a single forum [...]
Language: Английский
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 334 - 334
Published: Feb. 1, 2025
Background/objectives: Propolis (bee glue) is a valuable bee product widely used as natural remedy, cosmetic ingredient, nutritional value enhancer and food biopreservative. The present research aims to investigate the phenolic content, antioxidant activity in vitro anti-inflammatory antitumor potential of six propolis samples from three regions Bulgaria (Vidin, Gabrovo Lovech). Methods: analysis compounds was determined by high-performance liquid chromatography (HPLC); ethanolic extracts assessed 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay ferric-reducing power (FRAP) assay; inhibition albumin denaturation method; human metastatic breast cancer cell line MDA-MB-231 using 3-(4,5-Dimethyl -2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Results: exhibited total content 190.4 317.0 mg GAE/g, flavonoid 53.4 79.3 QE/g caffeic acid derivatives 5.9 12.1 CAE/g. studied showed significant capacity (between 1000.3 1606.0 mM TE/g DPPH assay, between 634.1 1134.5 FRAP assay). chemical composition indicated high concentrations benzyl ester, chrysin, pinocembrin pinobanksin-3-O-propionate, predominantly originating Lovech regions. All demonstrated promising activity, expressed thermally induced 73.59% 78.44%, which higher than that conventional drugs Aspirin (58.44%) Prednisolone Cortico (57.34%). cytotoxicity against cells with IC50 values ranging 9.24 13.62 µg/mL MTT Conclusions: Overall, we can suggest Bulgarian respective areas contributes its enhanced antioxidant, activity. Taken together, our results support beneficial properties propolis, application therapeutic agent.
Language: Английский
Citations
1
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139783 - 139783
Published: Aug. 28, 2024
Language: Английский
Citations
4
BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 170, P. 02008 - 02008
Published: Jan. 1, 2025
This study aimed to investigate the physicochemical characteristics and biological potential of fruits (dried frozen) four wild growing medicinal plants from Dospat region, Rhodope Mountain, Bulgaria – rosehip ( Rosa canina ), black elder Sambucus nigra cranberry Vaccinium vitis-idaea ) juniper (Juniperus communis). The properties (moisture, ash, carbohydrates, proteins vitamin C contents) were determined. Afterwards, activities (total phenolic content - TPC, total flavonoid TFC, antioxidant, antimicrobial anti-inflammatory) methanolic extracts investigated. TPC values varied between 5.37 mg GAE/g dw berry) 19.64 (frozen cranberry), while TFC 1.26 QE/g rosehip) 9.74 elderberry). antioxidant activity determined by DPPH method 24.23 mM TE/g 154.63 those obtained FRAP 23.06 138.54 cranberry). showed moderate high activity. berry elderberry demonstrated anti-inflammatory potential. results revealed great studied berries for application in pharmaceutical functional food products.
Language: Английский
Citations
0
Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6198 - 6198
Published: Aug. 23, 2023
Helichrysum italicum has piqued the interest of many researchers in recent years, mostly for its essential oil, but increasingly polyphenolic content as well. In current study, we examine composition H. grown Bulgaria. The complex was fractionated with solvents various polarities, including hexane, chloroform, ethyl acetate, and butanol, order to assess biological impact components. HPLC-PDA UHPLC-MS/MS were used all fractions. green coffee fingerprint profile employed a “surrogate standard” components detection approach. From analysis, identified 60 such quercetin 3-O-glucuronide, acetyl-glycoside, isorhamnetin caffeoyl-glycoside, caffeoyl-malonyl-glycoside, coumaroyl-glycoside, coumaroyl-caffeoylquinic acid, diCQA-acetyl-derivative first reported italicum. activity fractions evaluated vitro silico, which included fight against oxidative stress (hydrogen peroxide scavenging (HPSA), hydroxyl radical (HRSA), metal-chelating (MChA)) nitrosative (nitric oxide activity) (NOSA)), anti-inflammatory, anti-arthritic activity. Results are presented IC50 ± SD μg/mL. analysis showed that EtOAc fraction characterized by highest HPSA (57.12 1.14 μg/mL), HRSA (92.23 1.10 MChA (5.60 0.17 NOSA (89.81 2.09 while hexane chloroform significantly higher anti-inflammatory (30.48 2.33 μg/mL, 62.50 1.69 μg/mL) compared standard ibuprofen. All three potential (102.93 8.62 108.92 4.42 84.19 3.89 μg/mL).
Language: Английский
Citations
6
Plants, Journal Year: 2024, Volume and Issue: 13(13), P. 1731 - 1731
Published: June 22, 2024
At present, there are no data in the scientific literature on studies aimed at characterizing
Language: Английский
Citations
1
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(24), P. 11754 - 11754
Published: Dec. 17, 2024
Since ancient times, essential oils obtained from various aromatic plants have been utilized as bioactive ingredients in medicines, foods and cosmetics. The present study aimed to investigate the chemical composition biological activities of St John’s Wort (Hypericum perforatum L.) oil (SJW EO) Bulgaria, which is known possess properties. Gas chromatography mass spectrometry (GC–MS) analysis, determination antioxidant activity (by ABTS method), an antimicrobial test vitro anti-inflammatory were performed. main classes compounds identified by GC–MS analysis monoterpenes (43.55%), followed sesquiterpenes (36.81%) alkanes (16.92%). predominant components SJW EO α-pinene (27.52%), β-pinene (10.08%), β-caryophyllene (6.77%), germacrene D (6.37%) caryophyllene oxide (4.48%). highest antibacterial was observed against Gram-negative bacteria Klebsiella pneumoniae ATCC 13883 (inhibition zone 12.0 mm) Pseudomonas aeruginosa 9027 11.0 mm). exhibited significant activity, results demonstrated that its effect stronger than those conventional drugs Prednisolon Cortico acetylsalicylic acid (Aspirin), used controls (all concentration 1 mg/mL). Bulgarian can be active ingredient new products for pharmaceutical cosmetic industries.
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 30(1), P. 107 - 107
Published: Dec. 30, 2024
Herein, we report the synthesis of a series new compounds by combining 2-aminobenzothiazole with various profens. The were characterized using techniques such as 1H- and 13C-NMR, FT-IR spectrometry, high-resolution mass spectrometry (HRMS), detailed HRMS analysis conducted for each molecule. Their biological activities tested in vitro, revealing significant anti-inflammatory antioxidant effects, comparable to those standard reference compounds. Lipophilicity was experimentally determined through partition coefficient (RM) measurements. To understand their binding affinity, molecular docking studies perfsormed analyze interactions human serum albumin (HSA). stability these predicted complexes further evaluated dynamics simulations. results highlight compounds’ promising activity strong affinity HSA. hybrid molecule between 2-ABT ketoprofen 3b demonstrates promise based on experimental data is supported silico calculations. Compound exhibits best hydrogen peroxide scavenging among compounds, an IC50 60.24 μg/mL. Furthermore, also displays superior activity, 54.64 μg/mL, making it more effective than ibuprofen (76.05 μg/mL).
Language: Английский
Citations
0
Processes, Journal Year: 2023, Volume and Issue: 11(9), P. 2802 - 2802
Published: Sept. 21, 2023
This Special Issue of Processes, entitled “Synthesis, Application, and Biological Evaluation Chemical Organic Compounds”, gathers the most recent work leading researchers in a single forum [...]
Language: Английский
Citations
0