Cynthichlorine Extracted from Ascidian Cynthia savignyi from Djibouti: Optimization of Extraction, In Vitro Anticancer Profiling, and In Silico Approach

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(4), P. 172 - 172

Published: April 16, 2025

This work focuses on the extraction of cynthichlorine from ascidian Cynthia savignyi, a molecule that has potential promise as an anticancer agent. The main objective was to optimize conditions and evaluate cytotoxic activity in tumor cell lines. Two methods, maceration Soxhlet extraction, were compared, with showing significantly higher yield (2.2 ± 0.2%) compared (1.0 0.2%). An optimization factors influencing performed using Box–Behnken method, temperature time have negative impact yield, optimal being below 25 °C those 12 h. Cytotoxic assessment revealed marked inhibition growth all tested lines (U87-MG, U2OS, NCI-N87, HCT116, A2780), IC50 values ranging 0.162 µg/mL U87-MG 0.576 NCI-N87. Finally, computational analysis showed exhibits high electronic stability notable affinity for some biological targets, including NM23-H2, suggesting its targeted therapy cancer treatment. These results pave way future studies therapeutic use cynthichlorine.

Language: Английский

Overview of Research on Leishmaniasis in Africa: Current Status, Diagnosis, Therapeutics, and Recent Advances Using By-Products of the Sargassaceae Family

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 523 - 523

Published: April 18, 2024

Leishmaniasis in Africa, which has been designated as a priority neglected tropical disease by various global organizations, exerts its impact on millions of individuals, primarily concentrated within this particular region the world. As result progressively grave epidemiological data, numerous governmental sectors and civil organizations have their endeavors widespread outbreak with objective devising appropriate remedies. This comprehensive examination delves into multiple facets parasitic ailment, scrutinizing associated perils, diagnostic intricacies, deficiencies existing therapeutic protocols. Despite established efficacy current treatments, they are not immune to deleterious incidents, particularly concerning toxicity emergence resistance, thus accentuating necessity exploring alternative avenues. Consequently, research only encompasses conventional approaches, but also extends scope encompass complementary medicinal techniques, thereby striving identify innovative solutions. A auspicious dimension study lies exploration natural substances by-products derived from some brown algae

Language: Английский