Molecularly Imprinted Adsorbent and Its Magnetic Version for Solid Phase Extraction of D‐Panthenol: Comparison of Synthesis Approaches, Properties, and Applicability for Different Real Samples Extraction DOI
Andrea Špačková,

Sandra Solčianska‐Schwarz,

Michaela Kövérová

et al.

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(5)

Published: May 1, 2025

ABSTRACT This study demonstrates the development of HPLC‐DAD method for determination D‐panthenol incorporating molecularly imprinted solid‐phase extraction sample preparation. Two types adsorbents, polymers synthesized by bulk polymerization (MIPs) and precipitation on surface magnetic particles (Fe₃O₄@MIP), were compared in terms adsorption properties application potential. D‐panthenol, a bioactive compound pharmaceutical cosmetic products, was used as template imprinting. The optimal mixture included 4‐vinylpyridine functional monomer methanol porogenic solvent. kinetics pseudo‐second‐order indicated chemisorption onto active sites adsorbent. Freundlich isotherm model, which fitted experimental data, suggested presence heterogeneous sorption adsorbents. MIPs Fe₃O₄@MIPs employed adsorbents from various samples (such body milk other personal care products) achieving good selectivity targeted substance. Recoveries MIP‐ Fe₃O₄@MIP‐based extractions 82.3% (RSD < 2.9%) 85.8% 3.6%), respectively. proposed exhibited satisfactory linearity over concentration range 5.6–100 µg mL⁻¹ ( R 2 = 0.9989) limit detection 1.7 mL⁻¹.

Language: Английский

Molecularly Imprinted Adsorbent and Its Magnetic Version for Solid Phase Extraction of D‐Panthenol: Comparison of Synthesis Approaches, Properties, and Applicability for Different Real Samples Extraction DOI
Andrea Špačková,

Sandra Solčianska‐Schwarz,

Michaela Kövérová

et al.

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(5)

Published: May 1, 2025

ABSTRACT This study demonstrates the development of HPLC‐DAD method for determination D‐panthenol incorporating molecularly imprinted solid‐phase extraction sample preparation. Two types adsorbents, polymers synthesized by bulk polymerization (MIPs) and precipitation on surface magnetic particles (Fe₃O₄@MIP), were compared in terms adsorption properties application potential. D‐panthenol, a bioactive compound pharmaceutical cosmetic products, was used as template imprinting. The optimal mixture included 4‐vinylpyridine functional monomer methanol porogenic solvent. kinetics pseudo‐second‐order indicated chemisorption onto active sites adsorbent. Freundlich isotherm model, which fitted experimental data, suggested presence heterogeneous sorption adsorbents. MIPs Fe₃O₄@MIPs employed adsorbents from various samples (such body milk other personal care products) achieving good selectivity targeted substance. Recoveries MIP‐ Fe₃O₄@MIP‐based extractions 82.3% (RSD < 2.9%) 85.8% 3.6%), respectively. proposed exhibited satisfactory linearity over concentration range 5.6–100 µg mL⁻¹ ( R 2 = 0.9989) limit detection 1.7 mL⁻¹.

Language: Английский

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