Cancers, Journal Year: 2024, Volume and Issue: 16(23), P. 3969 - 3969
Published: Nov. 26, 2024
Ovarian carcinoma (OC) has an unfavorable prognosis due to lack of screening and asymptomatic course. New diagnostic methods are being sought enable earlier diagnosis this condition. The purpose study was determine the utility collagenases (MMP-1, MMP-8 MMP-13) in OC compared HE4 CA125 ROMA.
Language: Английский
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Feb. 24, 2025
Meigs' syndrome is a rare gynecological condition characterized by benign ovarian tumor, ascites, and pleural effusion, all of which resolve spontaneously after tumor removal. While mildly elevated serum CA-125 levels are frequently observed, exceeding 1,000 IU/mL extremely rare, concurrent elevation other markers, such as HE-4, may further complicate its diagnosis. We report case in 41-year-old premenopausal woman. Initial presenting symptoms included severe dyspnea, abdominal distention, anorexia, weight loss. Subsequent imaging studies revealed large right accompanied massive ascites effusion. Serum HE-4 were markedly (1,200 82.1 pmol/L, respectively), with Risk Ovarian Malignancy Algorithm (ROMA) score 25.63%, suggesting advanced malignancy. Neoadjuvant chemotherapy was initiated, but the continued to grow, necessitating internal debulking surgery. Postoperative histopathology fibroma, confirming diagnosis syndrome. Spontaneous resolution effusion occurred second postoperative day, markers normalized within next six months. The patient remained disease-free at 2-year follow-up. This underscores importance considering patients an unresponsive chemotherapy, concomitant Early recognition surgical intervention critical for accurate optimal management this condition.
Language: Английский
Citations
0
Cancer Reports, Journal Year: 2025, Volume and Issue: 8(3)
Published: March 1, 2025
ABSTRACT Background Ovarian cancer is frequently occurring and fatal for women. CA‐125 important in the screening, diagnosis, treatment of ovarian cancer. This review study was conducted to explore influence addressing Methods To investigate role cancer, we a comprehensive search high‐quality articles Medline, Web Science Core Collection Scopus databases using keywords “ovarian cancer,” carcinoma,” neoplasms,” “CA‐125” from 2000 2024. We included full‐text, peer‐reviewed English with relevant published since 2000. excluded case reports, commentaries, letters editor, books, series, systematic reviews, animal studies, that were not accessible full text. Results After screening 7947 records, 88 studies this review. In literature review, it found researchers utilized diagnosing its predicting, evaluating response, assessing survival, early detection recurrence. some cases, employed additional tumor markers alongside enhance test's sensitivity. Conclusion has become pivotal marker Its treatment, ongoing assessment cannot be overstated. Continuous monitoring levels can provide insights, categorizing patients as low‐risk or high‐risk based on could lead better outcomes. Integrating other biomarkers may accuracy test elevate relevance patient care.
Language: Английский
Citations
0
Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3082 - 3082
Published: Sept. 4, 2024
Cisplatin is one of the most well-known anti-cancer drugs and has demonstrated efficacy against numerous tumor types for many decades. However, a key challenge with cisplatin, as any chemotherapeutic agent, development resistance resultant loss efficacy. This often associated metabolic alterations that allow insensitive cells to divide survive under treatment. These adaptations could vary greatly among different may seem questionable incomprehensible at first glance. Here we discuss disturbances in glucose, lipid, amino acid metabolism cisplatin-resistant well roles ferroptosis autophagy acquiring this type drug intolerance.
Language: Английский
Citations
3
Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4203 - 4203
Published: Sept. 4, 2024
This study evaluates radio-iodinated anastrozole ([125I]anastrozole) and epirubicin ([125I]epirubicin) for AKT1-targeted breast cancer therapy, utilizing radiopharmaceutical therapy (RPT) personalized treatment. Through molecular docking dynamics simulations (200 ns), it investigates these compounds’ binding affinities mechanisms to the AKT1 enzyme, compared co-crystallized ligand, a known inhibitor. Molecular results show that [125I]epirubicin has highest ΔGbind (−11.84 kcal/mol), indicating superior affinity [125I] (−10.68 kcal/mol) ligand (−9.53 kcal/mol). (MD) confirmed stable interaction with [125I]anastrozole reaching stability after approximately 68 ns an average RMSD of around 2.2 Å, while stabilized at 2.69 Å 87 ns. RMSF analysis showed no significant shifts in residues or segments, consistent patterns differences less than 2 maintaining enzyme stability. The complex maintained four H-bonds, strong interactions, consistently formed three H-bonds. Rg values both complexes were ~16.8 ± 0.1 changes enzyme’s compactness, thus preserving structural integrity. These analyses reveal minimal perturbations, suggesting high potential inhibition. MM-PBSA calculations confirm compounds as inhibitors, exhibiting most favorable energy (−23.57 0.14 (−20.03 0.15 (−16.38 highlighting role electrostatic interactions stabilizing complex. computational shows may play promising roles especially its dynamic receptor interactions. findings, supported by scores energies, advocate their inhibitory capability against enzyme. Nevertheless, is crucial validate predictions through vitro vivo studies thoroughly evaluate therapeutic viability
Language: Английский
Citations
1
Global Medical Genetics, Journal Year: 2024, Volume and Issue: 11(04), P. 358 - 365
Published: Oct. 29, 2024
Ovarian cancer (OC) is one among most significantly fatal gynecological cancers, with late-stage detection and an inadequate prognosis. Plasminogen activator inhibitor-1 (
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1052 - 1052
Published: May 10, 2024
Reactive oxygen species (ROS) play an important and controversial role in carcinogenesis. Microsomal redox chains containing NADH- NADPH-dependent oxidoreductases are among the main sites of intracellular ROS synthesis, but their oxidative balance has not been fully studied. Here, we studied activity cytochrome b5 reductase (CYB5R) P450 (CYPOR) ovarian cancer tissues cells isolated from peritoneal fluid, along with antioxidant capacity fluid. We used developed a chemiluminescence assay based on stimulation NADH NADPH, which reflects CYB5R CYPOR, respectively. The CYPOR was significantly higher moderately poorly differentiated adenocarcinomas compared well-differentiated cystadenomas. For chemotherapy-resistant tumors, tissue lower to non-resistant tumors. In increased this series, benign tumors < adenocarcinomas, so excess observed for adenocarcinomas. fluid were characterized by direct moderate correlation These results indicate significant NAD(P)H potential biochemistry. parameters useful diagnostics prognostics. can be analyze other cells.
Language: Английский
Citations
0
Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 119992 - 119992
Published: Oct. 10, 2024
Language: Английский
Citations
0
Genes, Journal Year: 2024, Volume and Issue: 15(11), P. 1487 - 1487
Published: Nov. 19, 2024
Aneuploidy is a prevalent cancer feature that occurs in many solid tumors. For example, high-grade serous ovarian shows high level of copy number alterations and genomic rearrangements. This makes variants appealing as diagnostic or prognostic biomarkers, well for their easy detection. In this study, we focused on (CN) losses shared by stem cells (CSCs) to identify chromosomal regions may be important CSC features and, turn, patients' prognosis.
Language: Английский
Citations
0
Cancers, Journal Year: 2024, Volume and Issue: 16(23), P. 3969 - 3969
Published: Nov. 26, 2024
Ovarian carcinoma (OC) has an unfavorable prognosis due to lack of screening and asymptomatic course. New diagnostic methods are being sought enable earlier diagnosis this condition. The purpose study was determine the utility collagenases (MMP-1, MMP-8 MMP-13) in OC compared HE4 CA125 ROMA.
Language: Английский
Citations
0