The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
A
convenient
and
practical
method
has
been
developed
for
synthesizing
various
N-aryl
pyrazoles
from
vinyl
sulfoxonium
ylides
diazonium
salts.
When
using
1,3-disubstituted
ylides,
the
reaction
selectively
yields
1,3,5-trisubstituted
pyrazoles.
On
other
hand,
employing
2,3-disubstituted
results
in
formation
of
1,3,4-trisubstituted
The
proceeds
through
novel
aryl
diazene-derived
ylide.
Furthermore,
this
efficiently
produces
aniline
derivatives
a
one-pot
transformation.
takes
place
under
transition
metal-free,
mild
conditions
easily
accessible
starting
materials,
making
it
approach
generating
pharmaceutical
chemistry.
Research on Chemical Intermediates,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
The
simple
extrusion
method
used
to
combine
metakaolin
(MK)
with
aminoethyl-3-aminopropyltriethoxysilane
(AEAPTES)
create
composite
(MK/AEAPTES)
is
described
in
this
article.
Owing
amine
group
inherent
on
MK,
it
exhibited
a
basic
nature.
novel
catalyst
for
the
synthesis
of
pyrazolyl
phosphonates
by
Michael-addition
reaction.
Significant
product
yields,
environmental
friendliness,
rapid
reaction
durations,
broad
range
substrate
compatibility,
and
lack
hazardous
solvent
requirement
make
these
reactions
remarkable.
Furthermore,
there
no
appreciable
decrease
activity
subsequently
five
recycles
separation
using
straightforward
filtration
technique
without
any
extraction.
synthesized
derivatives
were
characterized
1H,
13C
NMR,
31P
NMR
&
FT-IR
analysis.
Synthesized
analyzed
FT-IR,
XRD,
SEM–EDX,
investigation
compared
MK.
recycled
also
checked
SEM–EDX
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
7(2)
Published: Feb. 13, 2025
Abstract
There
is
an
increase
in
infectious
diseases
every
year.
Heterocyclic
compounds
have
been
use
as
drugs
for
a
long
time.
Amongst
many
heterocyclic
derivatives,
the
containing
pyrazole
core
has
limelight
because
of
its
relative
ease
synthesis
and
excellent
biological
activities.
Pyrazoles
are
aromatic
consisting
ring
structure
where
two
nitrogen
atoms
adjacent
to
each
other
contain
three
carbon
atoms.
Over
years
pyrazoles
explored
variety
pharmacological
applications.
Herein,
this
review
overviews
information
related
industrially
important
pyrazoline
scaffolds
their
applications,
recent
literature
on
synthesizing
providing
explanation
activity
by
focusing
structural
relationship
hence
affording
ideas
design
scaffolds.
Graphical
abstract
Advances in chemical and materials engineering book series,
Journal Year:
2025,
Volume and Issue:
unknown, P. 55 - 102
Published: Jan. 3, 2025
This
chapter
discusses
about
bioactive
pyrazoles,
which
have
garnered
substantial
attention
in
medicinal
chemistry
and
drug
development.
Pyrazoles
are
five-membered
heterocyclic
compounds
characterized
by
a
nitrogen-rich
structure,
imparting
them
with
unique
physicochemical
biological
making
useful
for
treating
various
diseases.
The
explores
the
synthesis,
structural
diversity,
functional
modifications
of
pyrazoles
that
enhance
their
bioactivity.
Detailed
discussions
highlight
mechanisms
action
therapeutic
potential
pyrazole
derivatives
pharmacological
areas,
including
anti-inflammatory,
anticancer,
antimicrobial,
antiviral,
neuroprotective,
other
applications.
also
looks
at
latest
research
advancements
chemistry,
new
ways
to
make
studies
on
how
structure
affects
activity.
By
exploring
many
uses
this
shows
importance
contemporary
developing
better
medicines.
