Biomedical Applications of Microfluidic Devices: A Review

Biosensors, Journal Year: 2022, Volume and Issue: 12(11), P. 1023 - 1023

Published: Nov. 16, 2022

Both passive and active microfluidic chips are used in many biomedical chemical applications to support fluid mixing, particle manipulations, signal detection. Passive devices geometry-dependent, their uses rather limited. Active include sensors or detectors that transduce chemical, biological, physical changes into electrical optical signals. Also, they transduction detect biological applications, highly versatile tools for disease diagnosis organ modeling. This review provides a comprehensive overview of the significant advances have been made development microfluidics devices. We will discuss function as micromixers sorters cells substances (e.g., microfiltration, flow displacement, trapping). Microfluidic fabricated using range techniques, including molding, etching, three-dimensional printing, nanofabrication. Their broad utility lies detection diagnostic biomarkers organ-on-chip approaches permit modeling cancer, well neurological, cardiovascular, hepatic, pulmonary diseases. Biosensor allow point-of-care testing, assays based on enzymes, nanozymes, antibodies, nucleic acids (DNA RNA). An anticipated field includes optimization techniques fabrication biocompatible materials. These developments increase versatility, reduce costs, accelerate time technology.

Language: Английский

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A polarization independent highly sensitive metasurface-based biosensor for lab-on-chip applications

Measurement, Journal Year: 2024, Volume and Issue: 231, P. 114652 - 114652

Published: April 6, 2024

Language: Английский

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Challenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring of Biofluids: From Lab to Market. A Review

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 8160 - 8183

Published: Feb. 20, 2024

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTChallenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring Biofluids: From Lab to Market. A ReviewHossein ChenaniHossein ChenaniDepartment Materials Science Engineering, Sharif University Technology, 14588 89694 Tehran, IranMore by Hossein ChenaniView Biographyhttps://orcid.org/0009-0009-6924-6491, Mohsen Saeidi*Mohsen SaeidiDepartment Iran*Tel: +98-21-6616 5262; Fax: +98-21-6600 5717; Email: [email protected]More SaeidiView Biographyhttps://orcid.org/0000-0001-5430-3339, MahsaSadat Adel RastkhizMahsaSadat RastkhizDepartment RastkhizView Biographyhttps://orcid.org/0009-0002-6628-6868, Nafiseh BolghanabadiNafiseh BolghanabadiDepartment BolghanabadiView Biographyhttps://orcid.org/0009-0004-1151-2201, Amir AghaiiAmir AghaiiDepartment AghaiiView Biographyhttps://orcid.org/0009-0006-2561-9119, Mina OroujiMina OroujiDepartment OroujiView Biographyhttps://orcid.org/0009-0007-6375-6437, HatamieAmir HatamieDepartment Chemistry Molecular Biology, Gothenburg, Sweden; Department Chemistry, Institute Advanced Studies in Basic Sciences (IASBS), Prof. Sobouti Boulevard, PO Box 45195-1159, Zanjan 45137-66731, HatamieView Biographyhttps://orcid.org/0000-0002-7085-893X, Abdolreza Simchi*Abdolreza SimchiDepartment IranCenter Bioscience Convergence Tehran 14588-89694, 5226; SimchiView Biographyhttps://orcid.org/0000-0002-9111-2977Cite this: Anal. Chem. 2024, 96, 20, 8160–8183Publication Date (Web):February 2024Publication History Received2 September 2023Accepted1 February 2024Revised24 January 2024Published online20 inissue 21 May 2024https://pubs.acs.org/doi/10.1021/acs.analchem.3c03942https://doi.org/10.1021/acs.analchem.3c03942review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views1518Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biotechnology,Carbohydrates,Electrodes,Hydrogels,Sensors Get e-Alerts

Language: Английский

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Biosensors for melanoma skin cancer diagnostics

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 250, P. 116045 - 116045

Published: Jan. 20, 2024

Language: Английский

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Advancements in food quality monitoring: integrating biosensors for precision detection

Sustainable Food Technology, Journal Year: 2024, Volume and Issue: 2(4), P. 976 - 992

Published: Jan. 1, 2024

The integration of advanced biosensors enhances the detection contaminants in food. This approach addresses challenges related to sensitivity, specificity, and environmental factors, ensuring food safety quality.

Language: Английский

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Polymer Waveguide-Based Optical Sensors—Interest in Bio, Gas, Temperature, and Mechanical Sensing Applications

Coatings, Journal Year: 2023, Volume and Issue: 13(3), P. 549 - 549

Published: March 3, 2023

In the realization of photonic integrated devices, materials such as polymers are crucial. Polymers have shown compatibility with several patterning techniques, generally affordable, and may be functionalized to obtain desired optical, electrical, or mechanical characteristics. Polymer waveguides a viable platform for optical connectivity since they easily adaptable on-chip on-board integration promise low propagation losses <1 dB/cm. Furthermore, polymer can made extremely flexible, able withstand bending, twisting, even stretching. Optical sensing is an interesting field research that gaining popularity in photonics. Due its huge potential use industries, waveguide-based sensors attracted lot attention. their resilience electromagnetic fields, operate better difficult situations, those found electrical power generating conversion facilities. this review, most widely used discussed Moreover, four significant applications polymer-waveguide based which include biosensing, gas sensing, temperature been debated.

Language: Английский

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A comprehensive review on recent progress in chitosan composite gels for biomedical uses

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132723 - 132723

Published: May 31, 2024

Language: Английский

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Extremozyme-Based Biosensors for Environmental Pollution Monitoring: Recent Developments

Biosensors, Journal Year: 2024, Volume and Issue: 14(3), P. 143 - 143

Published: March 14, 2024

Extremozymes combine high specificity and sensitivity with the ability to withstand extreme operational conditions. This work presents an overview of extremozymes that show potential for environmental monitoring devices outlines latest advances in biosensors utilizing these unique molecules. The characteristics various described so far are presented, underlining their stability conditions make them attractive biosensing. biosensor design is discussed based on detection photosynthesis-inhibiting herbicides as a case study. Several pesticides, heavy metals, phenols presented more detail highlight interesting substrate specificity, applications or immobilization methods. Compared mesophilic enzymes, integration faces additional challenges related lower availability production costs. use biosensing does not parallel success industrial applications. In recent years, “collection” recognition elements was enriched by selectivity thermostable chimeras. perspectives development exciting, considering also progress genetic editing oriented efficient folding, better electron transport. Stability, costs at sensing interfaces must be improved encourage wider biosensors.

Language: Английский

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Mom and Baby Wellness with a Smart Lactation Pad: A Wearable Sensor‐Embedded Lactation Pad for on‐Body Quantification of Glucose in Breast Milk

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Abstract Wearable sensors are transforming healthcare by facilitating rapid, non‐invasive, on‐body biochemical analysis in biofluids such as sweat, tears, saliva, and blood, providing real‐time insights into health conditions. Despite extensive academic industrial efforts developing wearable devices, very few tailored to meet women's needs. None specifically designed for measurements human breast milk. Beyond being the optimal source of infant nutrition, milk serves a rich biofluid containing potential biomarkers reflecting mother's well. Analyzing composition offers valuable information infant, mother. This work pioneers sensor embedded lactation pad sampling continuous glucose levels Lactation pads worn most lactating individuals absorb leakage during day, keep cloth dry. In this work, integrating microfluidic channels electrochemical pad, becomes part an existing daily routine mother, posing no additional burden analysis. The developed using laser‐induced carbonization polyimide thin films, allowing development flexible, low‐cost, high‐surface area electrodes. Glucose sensing is done via enzymatic membrane composed oxidase, glutaraldehyde, bovine serum albumin, Nafion achieve enhanced enzyme protection extended biosensor shelf life operation Notably, device demonstrates high accuracy (96.8 104.1%) measurement whole undiluted milk, collected 1st, 6th, 12th months postpartum. innovative smart empowers mothers track their babies' intake potentially identify early signs concerns.

Language: Английский

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Why the superb physiological capacity of birds matters

Journal of Experimental Biology, Journal Year: 2025, Volume and Issue: 228(Suppl_1)

Published: Feb. 15, 2025

ABSTRACT Among vertebrates, birds undertake the longest, fastest and highest migrations of any taxonomic group, largely due to their unique cardiorespiratory system, which permits for very large rates gas exchange. Managing resultant elevated production reactive oxygen species, thus oxidative stress, has meant that can avoid pathologies relating major medical challenges now probably account majority global healthcare spending. Hypoxia underlies most critical illnesses faced by humans, but avian system supply far more per unit time than mammal. Birds have high circulating glucose levels, adaptations cope with stress brought about hyperglycaemia. also inflammatory responses obesity in humans when they seasonally gain huge fat stores. Lastly, live four times longer similarly sized mammals, seasonal endogenous muscle hypertrophy, some even increase telomere length age. A new frontier ‘physiologging’ is emerging, making use technologies use, provide novel parameters better understanding biomechanics, energetics ecology a range species. These physiologging tools are likely insight into physiology, biomechanics including ability spread disease, as well each detailed this Commentary. By virtue physiological capacity, study physiology area future discovery research using applied interdisciplinary areas physiology.

Language: Английский

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