Detection of hemoglobin in blood and urine glucose level samples using a graphene-coated SPR based biosensor

OSA Continuum, Journal Year: 2021, Volume and Issue: 4(8), P. 2164 - 2164

Published: July 16, 2021

In this paper, we have presented a design and simulation of graphene-coated surface plasmon resonance (SPR) based biosensor for targeting specific biological components. We explicitly shown the detection hemoglobin level in blood samples glucose concentration urine by using finite element method (FEM) numerical simulation. component, 0.001 refractive index increment causes 6.1025 g/l (HB) increment, which has been detected SPR sensor with 200 deg/RIU angular sensitivity. Moreover, also presence or absence diabetes sensor. Therefore, novelty paper is detecting levels more accurately than previously proposed whispering gallery mode (WGM) photonic crystal nanocavity optical sensors.

Language: Английский

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SPR Based Biosensing Chip for COVID-19 Diagnosis—A Review

IEEE Sensors Journal, Journal Year: 2022, Volume and Issue: 22(14), P. 13800 - 13810

Published: June 14, 2022

Surface Plasmon Resonance (SPR) techniques are highly accurate in detecting biomolecular like blood group measurement, food adulteration, milk adulteration and recently developing as a rapid detection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In order to validate the clinical diagnosis, Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal swabs has been utilized, which is time consuming expensive. For fast SARS-CoV-2 virus, SPR based biosensing chips described this review article. sensors have potential be employed fast, accurate, portable virus diagnosis. To combat pandemic, there considerable interest creating innovative biosensors that quick, reliable, sensitive COVID-19

Language: Английский

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Hemoglobin detection in blood samples using a graphene-based surface plasmon resonance biosensor

Optik, Journal Year: 2022, Volume and Issue: 270, P. 169947 - 169947

Published: Sept. 12, 2022

Language: Английский

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Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection

Biosensors, Journal Year: 2022, Volume and Issue: 12(8), P. 603 - 603

Published: Aug. 5, 2022

In this article, a hybrid TiO2/Au/graphene layer-based surface plasmon resonance (SPR) sensor with improved sensitivity and capability for cancer detection is presented. The finite element method (FEM) was used numerical analysis. proposed SPR biosensor structured based on the angular analysis of attenuated total reflection (ATR) various types using refractive index component. angle shifted owing to increment normal cancerous cells' index, which varied between 1.36 1.401 six different cells. According results, obtained sensitivities skin (basal), cervical (HeLa), adrenal gland (PC12), blood (Jurkat), breast (MCF-7 MDA-MB-231) cells were 210 deg/RIU, 245.83 264.285 285.71 292.86 278.57 respectively. Furthermore, accuracy (DA), figure merits (FOM), signal-to-noise ratio (SNR) also obtained, values 0.263 deg-1, 48.02 RIU-1, 3.84, Additionally, distribution electric field propagation magnetic resonant non-resonant conditions structure illustrated. It found that an enhanced exhibited plasmonic material conditions. We measured penetration depth 180 nm decayed intensity. impact layer demonstrated. further conducted analyses effects thickness gold additional graphene layers overall cancer. layered highest in terms detecting from healthy Moreover, numerically analyzed wide range biological solutions (refractive 1.33-1.41), linearity calculated linear regression coefficient (R2) 0.9858. Finally, results manuscript high comparison previously reported studies.

Language: Английский

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Design of Graphene Metasurface Sensor for Efficient Detection of COVID-19

Plasmonics, Journal Year: 2023, Volume and Issue: 18(6), P. 2335 - 2345

Published: July 19, 2023

Language: Английский

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Design and Analysis of Highly Sensitive Plasmonic Sensor Based on 2-D Inorganic Ti-MXene and SrTiO₃ Interlayer

IEEE Sensors Journal, Journal Year: 2023, Volume and Issue: 23(12), P. 12727 - 12735

Published: April 28, 2023

Using appropriate interlayers, the sensitivity and performance of conventional surface plasmon resonance (SPR) sensors can be improved in Kretschmann configuration. In this article, nano-layered SrTiO3 is proposed as an interlayer, which besides protecting silver from oxidation, due to high refractive index zero loss visible region, increases field intensity sensitivity. The use Ti3C2 Tx MXene layer also leads better adsorption biomolecules binding energies large area. structural engineering, we optimized physical parameters device. theoretical results show that sensor has a 301.2°/RIU 164% higher than Ag-only sensor, detection accuracy (DA) $0.119^{\circ -{1}}$ , quality factor 35.84 RIU notation="LaTeX">$^{-{1}}$ range 1.33–1.3377 near-zero minimum reflectance for 43 nm Ag, 12 SrTiO3, monolayer MXene. Therefore, promising used diagnostic applications portable biosensors. Although, reach highest 438.4°/RIU 103.9 48 Ag 13 without any non-bio (other) applications. However, using 2-D materials such efficiency biosensor. Furthermore, by difference method, 8000%/RIU.

Language: Английский

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Applications of nanomaterial technology in biosensing

Journal of Science Advanced Materials and Devices, Journal Year: 2024, Volume and Issue: 9(2), P. 100694 - 100694

Published: March 2, 2024

Nanomaterial technology is a comprehensive subject with strong intersections, and its related research content involves wide range of modern scientific technological fields. The science in the area nanomaterials has attracted attention many groups over past few years. By very nature, this topic lot room for research, to tiny objects nanometer range. Nanomaterials refer sudden changes properties substances when they reach scale, resulting special properties. In paper, we introduce various commonly used field biosensing, briefly explain advantages disadvantages nanoscale biosensors. At same time, also working principles types biosensors based on nanomaterial technology, including electrochemical biosensors, optical piezoelectric addition, sensing targets common such as enzymes, DNA, microorganisms, etc. Finally, discuss challenges prospects application analyze current trends future directions.

Language: Английский

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Fluorinated graphene and CNT-based surface plasmon resonance sensor for detecting the viral particles of SARS-CoV-2

Physica B Condensed Matter, Journal Year: 2023, Volume and Issue: 669, P. 415282 - 415282

Published: Sept. 21, 2023

Language: Английский

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Gold, MXene, and graphene nanofilm-based surface plasmon resonance sensor for malaria detection

Journal of Optics, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 18, 2024

Language: Английский

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Advancing SERS as a quantitative technique: challenges, considerations, and correlative approaches to aid validation

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: Aug. 17, 2024

Surface-enhanced Raman scattering (SERS) remains a significant area of research since it's discovery 50 years ago. The surface-based technique has been used in wide variety fields, most prominently chemical detection, cellular imaging and medical diagnostics, offering high sensitivity specificity when probing quantifying chosen analyte or monitoring nanoparticle uptake accumulation. However, despite its promise, SERS is mostly confined to academic laboratories not recognised as gold standard analytical technique. This due the variations that are observed measurements, mainly caused by poorly characterised substrates, lack universal calibration methods uncorrelated results. To convince wider scientific community should be routinely technique, field now focusing on will increase reproducibility signals how validate results with more well-established techniques. review explores difficulties experienced users, adopted reduce variation suggestions best practices strategies if one achieve absolute quantification.

Language: Английский

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