Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 13, 2025
Cancer
remains
a
significant
health
issue,
resulting
in
around
10
million
deaths
per
year,
particularly
developing
nations.
Demographic
changes,
socio-economic
variables,
and
lifestyle
choices
are
responsible
for
the
rise
cancer
cases.
Despite
potential
to
mitigate
adverse
effects
of
by
early
detection
implementation
prevention
methods,
several
nations
have
limited
screening
facilities.
In
oncology,
use
artificial
intelligence
(AI)
represents
transformative
advancement
diagnosis,
prognosis,
treatment.
The
AI
biomarker
discovery
improves
precision
medicine
uncovering
signatures
that
essential
treatment
diseases
within
vast
diverse
datasets.
Deep
learning
machine
diagnostics
two
examples
technologies
changing
way
biomarkers
made
finding
patterns
large
datasets
making
new
make
it
possible
deliver
accurate
effective
therapies.
Existing
gaps
include
data
quality,
algorithmic
transparency,
ethical
concerns
privacy,
among
others.
methodologies
with
seeks
transform
improving
patient
survival
rates
through
enhanced
diagnosis
targeted
therapy.
This
commentary
aims
clarify
how
is
identification
novel
optimal
focused
treatment,
improved
clinical
outcomes,
while
also
addressing
certain
obstacles
issues
related
application
oncology.
Data
from
reputable
scientific
databases
such
as
PubMed,
Scopus,
ScienceDirect
were
utilized.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
352, P. 122899 - 122899
Published: July 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Foods,
Journal Year:
2024,
Volume and Issue:
13(23), P. 3886 - 3886
Published: Dec. 1, 2024
Foodborne
pathogens
are
microorganisms
that
cause
illness
through
contamination,
presenting
significant
risks
to
public
health
and
food
safety.
This
review
explores
the
metabolites
produced
by
these
pathogens,
including
toxins
secondary
metabolites,
their
implications
for
human
health,
particularly
concerning
cancer
risk.
We
examine
various
such
as
Salmonella
sp.,
Campylobacter
Escherichia
coli,
Listeria
monocytogenes,
detailing
specific
of
concern
carcinogenic
mechanisms.
study
discusses
analytical
techniques
detecting
chromatography,
spectrometry,
immunoassays,
along
with
challenges
associated
detection.
covers
effective
control
strategies,
processing
techniques,
sanitation
practices,
regulatory
measures,
emerging
technologies
in
pathogen
control.
manuscript
considers
broader
highlighting
importance
robust
policies,
awareness,
education.
identifies
research
gaps
innovative
approaches,
recommending
advancements
detection
methods,
preventive
policy
improvements
better
manage
foodborne
metabolites.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 8, 2025
Abstract
Cancer
is
a
major
global
health
challenge,
with
approximately
19.3
million
new
cases
and
10
deaths
estimated
by
2020.
Laboratory
advancements
in
cancer
detection
have
transformed
diagnostic
capabilities,
particularly
through
the
use
of
biomarkers
that
play
crucial
roles
risk
assessment,
therapy
selection,
disease
monitoring.
Tumor
histology,
single-cell
technology,
flow
cytometry,
molecular
imaging,
liquid
biopsy,
immunoassays,
diagnostics
emerged
as
pivotal
tools
for
detection.
The
integration
artificial
intelligence,
deep
learning
convolutional
neural
networks,
has
enhanced
accuracy
data
analysis
capabilities.
However,
developing
countries
face
significant
challenges
including
financial
constraints,
inadequate
healthcare
infrastructure,
limited
access
to
advanced
technologies.
impact
COVID-19
further
complicated
management
resource-limited
settings.
Future
research
should
focus
on
precision
medicine
early
diagnosis
sophisticated
laboratory
techniques
improve
prognosis
outcomes.
This
review
examines
evolving
landscape
detection,
focusing
breakthroughs
limitations
countries,
while
providing
recommendations
advancing
tumor
resource-constrained
environments.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 454 - 454
Published: Feb. 12, 2025
Conditions
like
diabetes
mellitus
(DM),
cancer,
infections,
inflammation,
cardiovascular
diseases
(CVDs),
and
gastrointestinal
(GI)
disorders
continue
to
have
a
major
global
impact
on
mortality
morbidity.
Medicinal
plants
been
used
since
ancient
times
in
ethnomedicine
(e.g.,
Ayurveda,
Unani,
Traditional
Chinese
Medicine,
European
Medicine)
for
the
treatment
of
wide
range
disorders.
Plants
are
rich
source
diverse
phytoconstituents
with
antidiabetic,
anticancer,
antimicrobial,
antihypertensive,
antioxidant,
antihyperlipidemic,
cardioprotective,
immunomodulatory,
and/or
anti-inflammatory
activities.
This
review
focuses
35
most
commonly
reported
these
disorders,
particular
emphasis
their
traditional
uses,
phytoconstituent
contents,
pharmacological
properties,
modes
action.
Active
phytomolecules
therapeutic
potential
include
cucurbitane
triterpenoids,
diosgenin,
limonoids
(azadiradione
gedunin),
which
exhibit
antidiabetic
triterpenoids
specifically
activating
Glucose
Transporter
Type
4
(GLUT4)
translocation.
Capsaicin
curcumin
demonstrate
anticancer
activity
by
deactivating
NF-κB
arresting
cell
cycle
G2
phase.
Antimicrobial
activities
observed
piperine,
reserpine,
berberine,
dictamnine,
chelerythrine,
allitridin,
latter
two
triggering
bacterial
lysis.
Quercetin,
catechin,
genistein
suppressing
CD8+
cytotoxic
T
function.
Ginsenoside
Rg1
ginsenoside
Rg3
treating
diseases,
PPARα
promoter,
PI3K/Akt
pathway.
In
contrast,
ternatin,
tannins,
quercitrin
regulating
arachidonic
acid
metabolism
cyclooxygenase
(COX)
lipoxygenase
activity.
Further
studies
warranted
fully
investigate
clinical
benefits
phytoconstituents,
as
well
elucidate
underlying
molecular
mechanisms
Cancers,
Journal Year:
2024,
Volume and Issue:
16(13), P. 2338 - 2338
Published: June 26, 2024
Non-small-cell
lung
cancer
(NSCLC)
comprises
approximately
85%
of
all
cases,
often
diagnosed
at
advanced
stages,
which
diminishes
the
effective
treatment
options
and
survival
rates.
This
systematic
review
assesses
utility
emerging
biomarkers-circulating
tumor
DNA
(ctDNA),
microRNAs
(miRNAs),
blood
mutational
burden
(bTMB)-enhanced
by
next-generation
sequencing
(NGS)
to
improve
diagnostic
accuracy,
prognostic
evaluation,
strategies
in
NSCLC.
Analyzing
data
from
37
studies
involving
10,332
patients
2020
2024,
highlights
how
biomarkers
like
ctDNA
PD-L1
expression
critically
inform
selection
personalized
therapies,
particularly
beneficial
stages
These
are
critical
for
assessments
dynamically
adapting
plans,
where
high
specific
genetic
mutations
(e.g.,
ALK
fusions,
EGFR
mutations)
significantly
guide
use
targeted
therapies
immunotherapies.
The
findings
recommend
integrating
these
into
standardized
clinical
pathways
maximize
their
potential
enhancing
precision,
ultimately
fostering
significant
advancements
oncology
improving
patient
outcomes
quality
life.
substantiates
predictive
value
emphasizes
need
ongoing
innovation
biomarker
research.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 827 - 827
Published: April 9, 2024
Tumor
angiogenesis,
the
formation
of
new
blood
vessels
within
tumor
microenvironment,
is
considered
a
hallmark
cancer
progression
and
represents
crucial
target
for
therapeutic
intervention.
The
microenvironment
characterized
by
complex
interplay
between
proangiogenic
antiangiogenic
factors,
regulating
vascularization
necessary
growth
metastasis.
study
angiogenesis
involves
spectrum
techniques,
spanning
from
biomarker
assessment
to
advanced
imaging
modalities.
This
comprehensive
review
aims
provide
insights
into
molecular
intricacies,
regulatory
dynamics,
clinical
implications
angiogenesis.
By
delving
these
aspects,
we
gain
deeper
understanding
processes
driving
in
tumors,
paving
way
development
novel
effective
therapies
fight
against
cancer.
Journal of Proteome Research,
Journal Year:
2024,
Volume and Issue:
23(7), P. 2651 - 2660
Published: June 5, 2024
Histone
dopaminylation
is
a
newly
identified
epigenetic
mark
that
plays
role
in
the
regulation
of
gene
transcription,
where
an
isopeptide
bond
formed
between
fifth
amino
acid
H3
(i.e.,
glutamine)
and
dopamine.
Recently,
we
developed
chemical
probe
to
specifically
label
enrich
histone
via
bioorthogonal
chemistry.
Given
this
powerful
tool,
found
glutamine
5
(H3Q5dop)
was
highly
enriched
colorectal
tumors,
which
could
be
attributed
high
expression
level
its
regulator,
transglutaminase
2
(TGM2),
colon
cancer
cells.
Due
enzyme
promiscuity
TGM2,
nonhistone
proteins
have
also
been
as
targets;
however,
dopaminylated
proteome
cells
still
remains
elusive.
Here,
utilized
our
from
manner
performed
proteomics
analysis.
Therefore,
425
were
identified,
many
are
involved
nucleic
metabolism
transcription
pathways.
More
importantly,
number
sites
successful
application
probe.
Overall,
these
findings
shed
light
on
significant
association
cellular
protein
development,
further
suggesting
targeting
pathways
may
become
promising
anticancer
strategy.
