The use of digital devices to monitor physical behaviour in motor neuron disease: a systematic review (Preprint)

Journal of Medical Internet Research, Journal Year: 2025, Volume and Issue: 27, P. e68479 - e68479

Published: March 1, 2025

Background Motor neuron disease (MND) is a progressive and incurable neurodegenerative disease. The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) the primary clinical tool for assessing severity progression in MND. However, despite its widespread use, it does not adequately capture extent of physical function decline. There an urgent need sensitive measures that can be used to robustly evaluate new treatments. Measures derived from digital devices are beginning assess progression. value establishing consensus approach standardizing use such devices. Objective We aimed explore how being quantify free-living behavior evaluated feasibility assessed implications monitoring future trials practice. Methods Systematic searches 4 databases were performed October 2023 June 2024. Peer-reviewed English-language articles (including preprints) examined people living with MND their included. Study reporting quality was using 22-item checklist (maximum possible score=44 points). Results In total, 12 met inclusion criteria data extraction. All studies longitudinal observational design, but collection, analysis, protocols varied. Quality assessment scores ranged between 19 40 points. Sample sizes 10 376 at baseline, declining over course study. Most accelerometer device worn on wrist, chest, hip, or ankle. Participants typically asked continuously wear 1 8 days 1- 4-month intervals, running weeks 24 months. Some participants full duration. Studies traditional end points focusing duration, intensity, frequency activity nontraditional features individual’s movement patterns. correlation coefficients (r) ALSFRS-R 0.31 0.78. Greater frequencies improved point sensitivity shown provide smaller sample size requirements shorter durations hypothetical trials. People found acceptable reported low burden. Adherence (67%) good, ranging approximately 86% 96%, differences evident locations. perspectives other users practice explored. Conclusions Remote infancy has potential function. It essential develop statement, working toward agreed standardized methods reporting.

Language: Английский

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Daily Variability in Sedentary Behaviour and Physical Activity Responsiveness in Older Women

Sensors, Journal Year: 2025, Volume and Issue: 25(7), P. 2194 - 2194

Published: March 30, 2025

Free-living physical behaviour (PB), from sedentarism through to vigorous activity (PA), is increasingly studied due its links health outcomes. However, it remains unclear whether pre-existing day-to-day regularity in certain PB patterns influences intervention responsiveness. Therefore, this study hypothesized that (1) inter-day variability PBs would decrease following a sedentary (SB) reduction intervention, and (2) those with high (low regularity) at baseline be less likely alter their compared low (high regularity). Thirty-six older women (73 ± 5 years) were allocated one of three groups: daily SB fragmentation (SBF) (n = 14), single bout continuous light-intensity PA/LIPA or (3) control 8), where no instructions vis-à-vis altering given. was objectively assessed (weeks 0 8) using three-dimensional accelerometry. Participants (48% the sample) (<25th sample percentile for PA length), showed greater reduction, increased average length (p < 0.05) week 8. These findings suggest may enhance This aligns theories habit formation self-regulation, indicating personalised interventions benefit wider range populations.

Language: Английский

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Accelerating frailty management: harnessing advances in accelerometer technology

European Geriatric Medicine, Journal Year: 2024, Volume and Issue: 15(3), P. 597 - 599

Published: April 30, 2024

Language: Английский

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The use of digital devices to monitor physical behaviour in motor neuron disease: a systematic review (Preprint)

Published: Nov. 6, 2024

Motor neuron disease (MND) is a progressive and incurable neurodegenerative disease. There an urgent need for sensitive measures of progression that can be used to robustly evaluate new treatments. Measures physical function, derived from digital devices, are beginning assess progression. Given MND relatively rare, there value in establishing consensus approach standardizing use such devices. This systematic review explored how devices being quantify free-living behaviour people living with (plwMND). We evaluated the feasibility using assessed implications monitoring future design clinical trials. Systematic searches four databases were performed October 2023 June 2024. Peer-reviewed articles (including pre-prints) written English language plwMND included. Twelve met inclusion criteria data extraction. Studies traditional endpoints focusing on duration, intensity, frequency activity or non-traditional features individual’s movement patterns. Greater frequencies improved endpoint sensitivity was shown provide smaller sample size requirements shorter durations hypothetical PlwMND found acceptable reported low burden. The perspectives other end-users practice not explored. Remote its infancy but has exciting potential function MND. It essential develop statement within community, working towards agreed standardised methods collection, analysis reporting.

Language: Английский

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