Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 21, 2024

Bone defects pose significant challenges in healthcare, with over 2 million bone repair surgeries performed globally each year. As a burgeoning force the field of tissue engineering, 3D printing offers novel solutions to traditional transplantation procedures. However, current 3D-printed scaffolds still face three critical material selection, methods, cellular self-organization and co-culture, significantly impeding their clinical application. In this comprehensive review, we delve into performance criteria that ideal should possess, particular focus on core faced by technology during translation. We summarize latest advancements non-traditional materials advanced techniques, emphasizing importance integrating organ-like technologies bioprinting. This combined approach enables more precise simulation natural structure function. Our aim writing review is propose effective strategies address these promote translation for defect treatment.

Language: Английский

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Volumetric Additive Manufacturing for Cell Printing: Bridging Industry Adaptation and Regulatory Frontiers

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: 11(1), P. 156 - 181

Published: Jan. 2, 2025

Volumetric additive manufacturing (VAM) is revolutionizing the field of cell printing by enabling rapid creation complex three-dimensional cellular structures that mimic natural tissues. This paper explores advantages and limitations various VAM techniques, such as holographic lithography, digital light processing, volumetric projection, while addressing their suitability across diverse industrial applications. Despite significant potential VAM, challenges related to regulatory compliance scalability persist, particularly in context bioprinted In India, lack clear guidelines intellectual property protections poses additional hurdles for companies seeking navigate evolving landscape bioprinting. study emphasizes importance collaboration among industry stakeholders, agencies, academic institutions establish tailored frameworks promote innovation ensuring safety efficacy. By bridging gap between technological advancement oversight, can unlock new opportunities regenerative medicine tissue engineering, transforming patient care therapeutic outcomes.

Language: Английский

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Advancements in Precision Agriculture: Exploring the Role of 3D Printing in Designing All-Terrain Vehicles for Farming Applications

International Journal of Science and Research (IJSR), Journal Year: 2024, Volume and Issue: 13(5), P. 861 - 868

Published: May 5, 2024

Modern farming operations require creative solutions to improve productivity and sustainability, ATVs are essential for performing activities like tillage, planting, spraying, harvesting, soil sampling, irrigation control in precision agriculture. The introduction of 3D printing has transformed the prototyping process by greatly decreasing time it takes create prototypes, allowing personalized designs, attaining intricate design complexities that were not possible with old manufacturing processes. plastic metal methods offer distinct benefits difficulties, which have consequences characteristics materials, speed printing, cost-effectiveness. This research examines existing literature, case studies, economic feasibility emphasize significant impact may on successful utilization making lightweight durable ATV components demonstrates enhanced performance, efficiency, functionality as compared traditional production techniques. Furthermore, this report offers specific suggestions conducting comprehensive investigations into material's properties through mechanical testing. It also proposes exploring efficient affordable implementation strategies, such optimizing supply chain. Additionally, recommends fostering widespread adoption agricultural machinery development agriculture practices collaborative partnerships. To summarize, study highlights crucial need adopting technology a key catalyst creativity, efficiency revolutionizing industry.

Language: Английский

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Review: additive manufacturing of fiber-reinforced composites

Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(27), P. 12219 - 12256

Published: July 1, 2024

Language: Английский

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Selective Laser Sintering of Polymers: Process Parameters, Machine Learning Approaches, and Future Directions

Journal of Manufacturing and Materials Processing, Journal Year: 2024, Volume and Issue: 8(5), P. 197 - 197

Published: Sept. 13, 2024

Selective laser sintering (SLS) is a bed fusion additive manufacturing technology that facilitates rapid, versatile, intricate, and cost-effective prototype production across various applications. It supports wide array of thermoplastics, such as polyamides, ABS, polycarbonates, nylons. However, plastic components using SLS poses significant challenges due to issues like low strength, dimensional inaccuracies, rough surface finishes. The operational principle involves utilizing high-power-density fuse polymer or metallic powder surfaces. This paper presents comprehensive analysis the process, emphasizing impact different processing variables on material properties quality fabricated parts. Additionally, study explores application machine learning (ML) techniques—supervised, unsupervised, reinforcement learning—in optimizing processes, detecting defects, ensuring control within SLS. review addresses key associated with integrating ML in SLS, including data availability, model interpretability, leveraging domain knowledge. underscores potential benefits coupling situ monitoring systems closed-loop strategies enable real-time adjustments defect mitigation during manufacturing. Finally, outlines future research directions, advocating for collaborative efforts among researchers, industry professionals, experts unlock ML’s full provides valuable insights guidance researchers regard 3D printing, highlighting advanced techniques charting course investigations.

Language: Английский

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Abrasive Water Jet Machining of Carbon Fiber-Reinforced PLA Composites: Optimization of Machinability and Surface Integrity for High-Precision Applications

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 445 - 445

Published: Feb. 8, 2025

Carbon fiber-reinforced polylactic acid (CFR-PLA) composites have emerged as a promising material for aerospace and automotive applications due to their superior mechanical strength environmental sustainability. However, challenges such surface irregularities dimensional instability during machining hindered wider adoption. This study investigates the performance of abrasive water jet (AWJM) in optimizing quality machinability CFR-PLA compared pure PLA. Under optimal parameters (3500 bar pressure, 800 mm/min traverse speed, 250 g/min flow rate), demonstrated 23% reduction roughness (Ra) 15% kerf taper angle (T) relative These results highlight stabilizing effect carbon fiber reinforcement, which enhances accuracy stability machining. The findings position AWJM an effective method processing CFR-PLA, enabling its use lightweight, high-precision aerodynamic components structural prototypes. addresses critical gap hybrid provides actionable insights sustainable manufacturing. Future research should explore reinforcement strategies, further parameter optimization, advanced post-processing techniques maximize CFR-PLA's potential demanding engineering applications.

Language: Английский

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A Technical–Economic Study on Optimizing FDM Parameters to Manufacture Pieces Using Recycled PETG and ASA Materials in the Context of the Circular Economy Transition

Polymers, Journal Year: 2025, Volume and Issue: 17(1), P. 122 - 122

Published: Jan. 6, 2025

This paper presents the results of research on technical–economic optimization FDM parameters (Lh—layer height and Id—infill density percentage) for manufacture tensile compression samples from recycled materials (r) PETG (polyethylene terephthalate glycol) ASA (acrylonitrile styrene acrylate) in context transition to a circular economy. To carry out our study, fundamental principle value analysis was used, which consists maximizing ratio between Vi Cp, where represents mechanical characteristic (tensile strength or compressive strength) Cp production cost. The this study showed that, case manufactured by (rPETG), parameter that significantly influences Vi/Cp ratios is Lh (the layer), while additively (rASA), decisively Id infill percentage). In (rPETG) signified Following parameters, using multiple-response optimization, we identified optimal parts rPETG rASA: = 0.20 mm 100%. demonstrated use plastics lends itself consumption model based

Language: Английский

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A Study on the Optimization of FDM Parameters for the Manufacturing of Compression Specimens from recycled ASA in the Context of the Transition to the Circular Economy

Engineering Technology & Applied Science Research, Journal Year: 2025, Volume and Issue: 15(1), P. 19898 - 19902

Published: Feb. 2, 2025

The present study investigates the optimization of FDM parameters, that is, height deposited layer in one pass (Lh) and filling percentage (Id), for manufacture compression specimens from recycled ASA (rASA) context transitioning to circular economy. Anycubic 4Max Pro 2.0 3D printer was utilized, where were additively manufactured rASA 45 using following variable parameters: Lh = 0.10 mm, 0.15 0.20 Id 50%, 75%, 100%. All tested on Barrus White 20 kN universal testing machine. It found Compressive strength (Cs) is influenced by two considered parameters Fused Deposition Modeling (FDM), Id, but overwhelmingly influencing parameter Id. According results rASA, mm

Language: Английский

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A review of strategies to control process-induced cracks in metal additive manufacturing and remanufacturing

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 111801 - 111801

Published: Feb. 1, 2025

Language: Английский

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Comparative Study on Extrusion 3D Printing of Solid Propellant Based on Plunger and Screw

Materials, Journal Year: 2025, Volume and Issue: 18(4), P. 777 - 777

Published: Feb. 10, 2025

Extrusion-based 3D printing holds great potential for manufacturing solid propellants. Among the various methods, screw- and plunger-based extrusion are most frequently reported techniques propellant printing, each employing different mechanisms. This paper compares flow characteristics of these two methods through a combination simulations experiments. Simulation results reveal that slurry in plunger device exhibits relatively stable characteristics, especially near nozzle outlet, with high velocity, shear rate, low-pressure distribution. Compared to screw-based device, achieves more uniform outlet velocity. In contrast, screw produces complex rheological behavior, backflow observed gap between channel wall. However, average pressure (3885.11 Pa) is notably lower than (7292.92 Pa). Experimental indicate quality comparable extrusion. These findings provide valuable insights into advancing extrusion-based 3D-printing processes

Language: Английский

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