Nanopipettes as a Potential Diagnostic Tool for Selective Nanopore Detection of Biomolecules DOI Creative Commons

Regina Kuanaeva,

Alexander N. Vaneev,

Petr V. Gorelkin

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 627 - 627

Published: Dec. 19, 2024

Nanopipettes, as a class of solid-state nanopores, have evolved into universal tools in biomedicine for the detection biomarkers and different biological analytes. Nanopipette-based methods combine high sensitivity, selectivity, single-molecule resolution, multifunctionality. The features significantly expanded interest their applications biomolecular detection, imaging, molecular diagnostics real samples. Moreover, ease manufacturing nanopipettes, coupled with compatibility fluorescence electrochemical methods, makes them ideal portable point-of-care diagnostic devices. This review summarized latest progress nanopipette-based nanopore technology biomarkers, DNA, RNA, proteins, peptides, particular β-amyloid or α-synuclein, emphasizing impact on diagnostics. By addressing key challenges expanding diverse areas, nanopipettes are poised to play transformative role future personalized medicine.

Language: Английский

Pioneering Role of Nanopore Single-Molecule Sensing in Environmental and Food Surveillance DOI Creative Commons

W. W. Tian,

Xu Wang, Yan Zhang

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(1), P. 41 - 41

Published: Jan. 13, 2025

In recent years, environmental and food safety have garnered substantial focus due to their intimate connection with human health. Numerous biosensors been developed for identifying deleterious compounds; however, these reveal certain limitations. Nanopore sensors, featuring nano-scaled pore size, demonstrated outstanding performance in terms of rapidity, sensitivity, selectivity as a single-molecule technique surveillance. this review, we present comprehensive overview nanopore applications two fields. To elucidate the pioneering roles nanopores, analytes are categorized into three distinct groups, including metal ions, synthetic contaminants, biotoxins. Moreover, variety strategies involved, such coalescence ligand probes, implementation chemical reactions, functionalization etc. These scientific studies showcase versatility diversity technique, paving way further developments technology safety.

Language: Английский

Citations

1
Nanopipettes as a Potential Diagnostic Tool for Selective Nanopore Detection of Biomolecules DOI Creative Commons

Regina Kuanaeva,

Alexander N. Vaneev,

Petr V. Gorelkin

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(12), P. 627 - 627

Published: Dec. 19, 2024

Nanopipettes, as a class of solid-state nanopores, have evolved into universal tools in biomedicine for the detection biomarkers and different biological analytes. Nanopipette-based methods combine high sensitivity, selectivity, single-molecule resolution, multifunctionality. The features significantly expanded interest their applications biomolecular detection, imaging, molecular diagnostics real samples. Moreover, ease manufacturing nanopipettes, coupled with compatibility fluorescence electrochemical methods, makes them ideal portable point-of-care diagnostic devices. This review summarized latest progress nanopipette-based nanopore technology biomarkers, DNA, RNA, proteins, peptides, particular β-amyloid or α-synuclein, emphasizing impact on diagnostics. By addressing key challenges expanding diverse areas, nanopipettes are poised to play transformative role future personalized medicine.

Language: Английский

Citations

0