Lab on Pipette: Robust Biochemical Sensing with Functional Laser-Induced Graphene Electrode Array for On-Site and Disposable Urine Analysis DOI
Xianyou Sun,

Zihan Jin,

Shaoxiang Zhang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Urine, abundant in disease-related biomarkers, offers advantages such as easy collection and noninvasiveness. Portable biochemical sensors are ideal for efficient on-site applications due to their flexibility accessibility. However, existing face challenges complex sample operations limited sensor renewal, hindering large-scale convenient urine analysis. This study presents the "lab on pipette" (LOP) concept address these issues, enabling The LOP system integrates a multifunctional pipette tip miniaturized system, facilitating detection of multiple biomarkers urine. Laser-induced graphene (LIG) technology fabricates an electrochemical electrode array flexible polyimide, custom-designed electrical interfaces ensure quick plug-and-play connections. Gold nano dendrites, Prussian blue (PB), nickel hexacyanoferrate (NiHCF) form multilayer functional interface, highly sensitive pH, hydrogen peroxide, glucose, ascorbic acid with pH compensation. NiHCF doping enhances PB stability, while nanoalumina-doped porous enzyme membranes improve repeatability reliability. dendrites anchor membrane curved surfaces, ensuring robust performance. achieves limits 7.19 8.57 μM glucose acid, respectively. Its low cost, disposability, portability, reliability highlight its potential personalized health monitoring.

Language: Английский

Study on Hybrid Assemblies of Graphene and Conducting Polymers with Embedded Gold Nanoparticles for Potential Electrode Purposes DOI Creative Commons
Alexandru Trandabăţ,

Oliver Daniel Schreiner,

Thomas Gabriel Schreiner

et al.

Chemosensors, Journal Year: 2025, Volume and Issue: 13(4), P. 130 - 130

Published: April 4, 2025

This article outlines the method of creating electrodes for electrochemical sensors using hybrid nanostructures composed graphene and conducting polymers with insertion gold nanoparticles. The technology employed dispersion support stabilization was based on chemical vapor deposition technique followed by delamination. used to obtain from conductive drop-casting, utilizing solutions P3HT, PANI-EB, F8T2. Additionally, nanoparticles utilized an innovative dip-coating technique, graphene-conducting polymer frameworks submerged in a HAuCl4/2-propanol solution subsequently subjected controlled heating. integration differs notably, P3HT showing least adhesion nanoparticles, while PANI-EB exhibits highest. An inkjet printer create metallization accomplished through use commercial silver ink. Notable variations roughness (grain size) result unique behaviors these structures, therefore, any potential differences sensitivity generated sensing structures can be more thoroughly understood this spatial arrangement. experiments diluted sulfuric acid at three different scan rates. oxidation reduction potentials seem fairly alike. Nevertheless, notable difference is seen anodic cathodic current densities, which appear largely influenced active surface linked polymeric grains. graphene–PANI-EB structure Au showed highest responsiveness will further evaluated biomedical applications.

Language: Английский

Citations

0

Lab on Pipette: Robust Biochemical Sensing with Functional Laser-Induced Graphene Electrode Array for On-Site and Disposable Urine Analysis DOI
Xianyou Sun,

Zihan Jin,

Shaoxiang Zhang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Urine, abundant in disease-related biomarkers, offers advantages such as easy collection and noninvasiveness. Portable biochemical sensors are ideal for efficient on-site applications due to their flexibility accessibility. However, existing face challenges complex sample operations limited sensor renewal, hindering large-scale convenient urine analysis. This study presents the "lab on pipette" (LOP) concept address these issues, enabling The LOP system integrates a multifunctional pipette tip miniaturized system, facilitating detection of multiple biomarkers urine. Laser-induced graphene (LIG) technology fabricates an electrochemical electrode array flexible polyimide, custom-designed electrical interfaces ensure quick plug-and-play connections. Gold nano dendrites, Prussian blue (PB), nickel hexacyanoferrate (NiHCF) form multilayer functional interface, highly sensitive pH, hydrogen peroxide, glucose, ascorbic acid with pH compensation. NiHCF doping enhances PB stability, while nanoalumina-doped porous enzyme membranes improve repeatability reliability. dendrites anchor membrane curved surfaces, ensuring robust performance. achieves limits 7.19 8.57 μM glucose acid, respectively. Its low cost, disposability, portability, reliability highlight its potential personalized health monitoring.

Language: Английский

Citations

0