Genetic Evidence for Estrogenic Effects of Benzophenone-2 on Zebrafish Neurodevelopment and Its Signaling Mechanism DOI
Zhipeng Qi,

Yue Zhai,

Yi Han

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Estrogens play a crucial role in regulating various biological responses during the early stages of neurodevelopment. Benzophenone-2 (BP2), widely used organic ultraviolet (UV) filter, has been proven as an estrogenic compound, whereas effects BP2 on neurodevelopment remain largely unknown. Here, we investigated neurodevelopmental toxicity by exposing zebrafish embryos from 2 to 120 h postfertilization (hpf) at environmentally relevant concentrations. We demonstrated that life exposure induced multiple concentration-dependent impairments nervous system, including hypoactivity, abnormal brain morphology, impaired neurocyte proliferation, shortened axon, and increased apoptosis. Moreover, metabolomic profiling revealed decrease dopamine (DA) its metabolites BP2-treated larvae. Using E2 treatment morpholino knockdown assays, provided strong genetic evidence BP2-induced behavioral disorders were associated with estrogen-dependent signaling, especially estrogen receptors 2a 2b (esr2). Subsequently, transcriptomic indicated activation esr2 further inhibited expression LIM homeobox transcription factor 1 β (lmx1ba), which is vital for normal Consistently, overexpression lmx1ba inhibition obviously alleviated BP2-caused neurotoxicity, uncovering seminal toxicity. Our findings provide first fish can induce deficits dysfunction offer novel insights into mechanisms well other emerging benzophenones.

Language: Английский

Exploring the Hidden Threat of Organic UV Filters to Corals and Macroalgae in Coral Reef Ecosystem from Luhuitou, Sanya, China DOI
Lina Lyu, Jie Li, Qinyu Huang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

The widespread presence of organic UV filters (OUVFs) in coral reef ecosystems has attracted increasing attention. This study analyzed the concentrations and compositions OUVFs corals, macroalgae, sediments Luhuitou fringing ecosystem Sanya, China. detected included benzophenones-1, -2, -3, -8 (BP-1, BP-2, BP-3, BP-8), 4-hydroxybenzoic acid (4-HB), octocrylene (OC), 4-methylbenzylidene camphor (4-MBC), octyl dimethyl-p-aminobenzoic (ODPABA). total (∑8OUVFs) tissues macroalgae were found to be 4.3–52.0 8.0–29.0 ng/g dry weight (dw), respectively. bioaccumulation factors (BAFs) for BPs (including BP-1, BP-8) OC higher than those while BAFs 4-MBC ODPABA relatively lower. Preliminary risk assessment results indicated that, worst-case scenario, more 65 84% samples had BP-3 exceeding thresholds causing larval bleaching mortality, At same time, 99% showed related their growth inhibition. Therefore, posed significant ecological risks corals subsequently threatening health stability ecosystem.

Language: Английский

Citations

0
UV filters in beach sands from beaches along the Atlantic Ocean coastline in Lagos, Nigeria: Occurrence and risk assessment DOI
Akinranti S. Ajibola,

Yusirat I. Ajulo,

Titilope O. Akinola

et al.

Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: 74, P. 103513 - 103513

Published: April 14, 2024

Language: Английский

Citations

1
A Revisit to Effervescence-Assisted Microextraction of Non-Polar Organic Compounds Using Hydrophobic Magnetic Nanoparticles—Application to the Determination of UV Filters in Natural Waters DOI Creative Commons

Efthymia Toti,

Vasiliki Gouma,

Vasiliki I. Karagianni

et al.

Separations, Journal Year: 2024, Volume and Issue: 11(11), P. 315 - 315

Published: Nov. 1, 2024

In this work, we revisited the method of effervescence-assisted microextraction, aiming to assess effects process effervescence on extraction efficiency organic compounds. We used a magnetic nano-sorbent material composed stearic acid-coated cobalt-ferrite nanoparticles as an adsorbent and dispersed it in water using 12 combinations acid base mixtures at two different mass ratios. The solution pH, ionic strength, duration were calculated correlated nonpolar UV filters from aqueous samples model Our findings provide general perspective into influence efficiency. Based these findings, developed optimized new analytical for extracting HPLC-UV detector. Under optimum experimental conditions (0.2 g fumaric acid/0.1 Na2CO3, 50 mg methanol elution solvent assisted by vortex agitation 5 min) was found afford good linearity calibration curves expanding orders magnitude, satisfactory reproducibility repeatability (1.8–11.1%), high recoveries (78.4–127.1%). This research provides compounds introduces media.

Language: Английский

Citations

0
Genetic Evidence for Estrogenic Effects of Benzophenone-2 on Zebrafish Neurodevelopment and Its Signaling Mechanism DOI
Zhipeng Qi,

Yue Zhai,

Yi Han

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Estrogens play a crucial role in regulating various biological responses during the early stages of neurodevelopment. Benzophenone-2 (BP2), widely used organic ultraviolet (UV) filter, has been proven as an estrogenic compound, whereas effects BP2 on neurodevelopment remain largely unknown. Here, we investigated neurodevelopmental toxicity by exposing zebrafish embryos from 2 to 120 h postfertilization (hpf) at environmentally relevant concentrations. We demonstrated that life exposure induced multiple concentration-dependent impairments nervous system, including hypoactivity, abnormal brain morphology, impaired neurocyte proliferation, shortened axon, and increased apoptosis. Moreover, metabolomic profiling revealed decrease dopamine (DA) its metabolites BP2-treated larvae. Using E2 treatment morpholino knockdown assays, provided strong genetic evidence BP2-induced behavioral disorders were associated with estrogen-dependent signaling, especially estrogen receptors 2a 2b (esr2). Subsequently, transcriptomic indicated activation esr2 further inhibited expression LIM homeobox transcription factor 1 β (lmx1ba), which is vital for normal Consistently, overexpression lmx1ba inhibition obviously alleviated BP2-caused neurotoxicity, uncovering seminal toxicity. Our findings provide first fish can induce deficits dysfunction offer novel insights into mechanisms well other emerging benzophenones.

Language: Английский

Citations

0