Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes? DOI Creative Commons

Karolina Ogórek,

Kinga Nowak,

Emilia Wadych

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(1), P. 136 - 136

Published: Jan. 1, 2025

Cosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers skin, this shortcoming significantly reduces their efficacy. One such CAC that occurs naturally in human body displays many beneficial properties (via reducing fine lines wrinkles, tightening improving its elasticity, etc.) is glycyl-L-histidyl-L-lysine tripeptide complex copper (GHK–Cu). GHK–Cu a fairly compound with limited permeation through stratum corneum. On other hand, liposomes capable encapsulating may improve potential. The present review discusses various issues related to obtaining insight into CACs skin. Methods for studying transport encapsulated by free across skin barrier are summarized. An analysis literature data reveals containing received little attention. This research gap gives an impetus methodological developments assessing effect on transportation trafficking.

Language: Английский

Are We Ready to Measure Skin Permeation of Modern Antiaging GHK–Cu Tripeptide Encapsulated in Liposomes? DOI Creative Commons

Karolina Ogórek,

Kinga Nowak,

Emilia Wadych

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(1), P. 136 - 136

Published: Jan. 1, 2025

Cosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers skin, this shortcoming significantly reduces their efficacy. One such CAC that occurs naturally in human body displays many beneficial properties (via reducing fine lines wrinkles, tightening improving its elasticity, etc.) is glycyl-L-histidyl-L-lysine tripeptide complex copper (GHK–Cu). GHK–Cu a fairly compound with limited permeation through stratum corneum. On other hand, liposomes capable encapsulating may improve potential. The present review discusses various issues related to obtaining insight into CACs skin. Methods for studying transport encapsulated by free across skin barrier are summarized. An analysis literature data reveals containing received little attention. This research gap gives an impetus methodological developments assessing effect on transportation trafficking.

Language: Английский

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