A Multidisciplinary Approach of Type 1 Diabetes: The Intersection of Technology, Immunotherapy, and Personalized Medicine DOI Open Access
Denisa Batîr-Marin, Claudia Simona Ștefan, Monica Boev

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2144 - 2144

Published: March 21, 2025

Background: Type 1 diabetes (T1D) is a chronic autoimmune disorder characterized by the destruction of pancreatic β-cells, leading to absolute insulin deficiency. Despite advancements in therapy and glucose monitoring, achieving optimal glycemic control remains challenge. Emerging technologies novel therapeutic strategies are transforming landscape T1D management, offering new opportunities for improved outcomes. Methods: This review synthesizes recent treatment, focusing on innovations continuous monitoring (CGM), automated delivery systems, smart formulations, telemedicine, artificial intelligence (AI). Additionally, we explore biomedical approaches such as stem cell therapy, gene editing, immunotherapy, gut microbiota modulation, nanomedicine-based interventions, trace element-based therapies. Results: Advances digital health, including CGM integration with hybrid closed-loop pumps AI-driven predictive analytics, have significantly real-time management. AI telemedicine enhanced personalized care patient engagement. Furthermore, regenerative medicine strategies, β-cell replacement, CRISPR-based immunomodulatory therapies, hold potential disease modification. Probiotics microbiome-targeted therapies demonstrated promising effects maintaining metabolic homeostasis, while elements provide additional regulate sensitivity oxidative stress. Conclusions: The future management shifting toward precision integrated technological solutions. While these present avenues, challenges long-term efficacy, safety, accessibility, clinical validation must be addressed. A multidisciplinary approach, combining research, intelligence, nanotechnology, will essential translate into practice, ultimately improving quality life individuals T1D.

Language: Английский

A Multidisciplinary Approach of Type 1 Diabetes: The Intersection of Technology, Immunotherapy, and Personalized Medicine DOI Open Access
Denisa Batîr-Marin, Claudia Simona Ștefan, Monica Boev

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2144 - 2144

Published: March 21, 2025

Background: Type 1 diabetes (T1D) is a chronic autoimmune disorder characterized by the destruction of pancreatic β-cells, leading to absolute insulin deficiency. Despite advancements in therapy and glucose monitoring, achieving optimal glycemic control remains challenge. Emerging technologies novel therapeutic strategies are transforming landscape T1D management, offering new opportunities for improved outcomes. Methods: This review synthesizes recent treatment, focusing on innovations continuous monitoring (CGM), automated delivery systems, smart formulations, telemedicine, artificial intelligence (AI). Additionally, we explore biomedical approaches such as stem cell therapy, gene editing, immunotherapy, gut microbiota modulation, nanomedicine-based interventions, trace element-based therapies. Results: Advances digital health, including CGM integration with hybrid closed-loop pumps AI-driven predictive analytics, have significantly real-time management. AI telemedicine enhanced personalized care patient engagement. Furthermore, regenerative medicine strategies, β-cell replacement, CRISPR-based immunomodulatory therapies, hold potential disease modification. Probiotics microbiome-targeted therapies demonstrated promising effects maintaining metabolic homeostasis, while elements provide additional regulate sensitivity oxidative stress. Conclusions: The future management shifting toward precision integrated technological solutions. While these present avenues, challenges long-term efficacy, safety, accessibility, clinical validation must be addressed. A multidisciplinary approach, combining research, intelligence, nanotechnology, will essential translate into practice, ultimately improving quality life individuals T1D.

Language: Английский

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