Prenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Language: Английский

Early Life Outcomes of Prenatal Exposure to Alcohol and Synthetic Cannabinoids in Mice

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract This study explores the effects of prenatal co-exposure to alcohol and synthetic cannabinoids on offspring viability, physical development, neurobehavioral outcomes in young adulthood. The aim is identify distinct compared single-drug exposures examine potential sex-specific vulnerabilities motor coordination exploratory behaviors. Pregnant C57Bl/6J mice were assigned one four treatment groups: Control, Alcohol-exposed, Cannabinoid-exposed, or Alcohol+Cannabinoid-exposed, with drug administration occurring between Gestational Days 12–15. Offspring first evaluated at birth for survival, malformations, developmental delays. Subsequently, adult assessed using rotarod tests behavior open field tests. Our results indicate that cannabinoid significantly reduced survival litter sizes controls. Non-viable displayed craniofacial abnormalities, limb Behavioral assessments adulthood demonstrated all forms exposure impaired males, while independently produced impairments females. In test, co-exposed male exhibited center exploration, indicative anxiety-like behavior. Co-exposed offspring, regardless sex, hyperactivity, characterized by increased speed distance traveled. Together, these findings underscore heightened risks associated polysubstance exposure, which exacerbates mortality induces deficits. highlights co-exposure, need future research investigate underlying mechanisms driving disruptions susceptibilities. Structured Purpose investigates goal this investigation determine whether produces from exposures, including Methods randomly drug-free controls, (ALC)-exposed, (CP-55,940, CB)-exposed ALC+CB-exposed, 12-15. delays birth. Then, behavioral evaluations, tests, conducted (Postnatal 100–120). Results ALC+CB decreased ( p = 0.006) viability Assessments performance revealed males controls < 0.05), ALC CB alone outcome Open indicated time arena exclusively, same hyperactivity control groups, independent sex 0.05). Conclusions Prenatal deficits outcomes. These highlight during pregnancy targeted interventions mitigate health Highlights Alcohol reduces survival. Reduced malformations. produce coordination. display

Language: Английский

Systematic review: the impact of maternal pre-and postnatal cannabis use on the behavioral and emotional regulation in early childhood

European Child & Adolescent Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: June 15, 2024

Abstract Prenatal exposure to alcohol and tobacco has been associated with child regulatory abilities problems, but less is known about the associations cannabis exposure. This review seeks address this gap primarily focusing on effects of maternal use child. Thus, we investigate association between pre- postnatal as well underlying neurobiological mechanisms potentially mediating associations. According PRISMA guidelines, a systematic literature was performed based search through Medline (PubMed), Web Science PsycInfo, including studies assessing children aged 0–6 years in preconception, pre-or period (preconception, [PCE]) investigating abilities, problems or mechanisms. Of n = 1061 screened articles, 33 were finally included. Diminished are more likely be found infants after PCE, while specific tend frequently two age. Possible related changes methylation expression key genes involved endocannabinoid, dopaminergic opioid systems, increased cortisol reactivity altered Secretory Immunoglobulin A levels. Furthermore, PCE brain structure connectivity. Current findings indicate that both age-dependent alterations self-regulation young children. However, evidence limited due number studies, small sample sizes lack control for psychopathology. Longitudinal psychometric data from mothers needed order further understand implications PCE. Trial registration : The registered PROSPERO (ID: CRD42023425115).

Language: Английский