Journal of Population Therapeutics and Clinical Pharmacology,
Journal Year:
2022,
Volume and Issue:
unknown
Published: May 10, 2022
Green
chemistry,
a
cornerstone
of
sustainable
practices,
is
transforming
the
pharmaceutical
industry
by
minimizing
or
eliminating
use
and
production
harmful
substances.
This
review
delves
deep
into
12
Pharmacy
Principles,
guiding
force
for
designing
eco-friendly
health-conscious
medication
processes.
We
explore
how
these
principles
are
being
implemented
across
various
aspects
drug
development,
from
molecule
design
synthesis
to
production,
distribution,
disposal.
Exciting
advancements
like
biocatalysis,
renewable
feedstocks,
innovative
solvents,
energy-efficient
methods
discussed,
showcasing
their
potential
minimize
environmental
impact
create
economic
opportunities.
By
embracing
green
principles,
can
pave
way
healthier
planet
ensure
development
safer
more
medications
generations
come.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 391 - 391
Published: Feb. 6, 2023
β-Sitosterol,
which
is
used
extensively
in
pharmaceuticals,
nutraceuticals,
and
cosmetics,
has
high
nutritional
value
along
with
immunomodulatory
anti-inflammatory
properties.
In
this
study,
we
investigated
the
antioxidant
effects
of
β-sitosterol
zebrafish
explored
associated
molecular
mechanisms.
an
vivo
experiment,
(Danio
rerio)
larvae
were
treated
different
concentrations
then
exposed
to
a
nonlethal
concentration
CuSO4
induce
oxidative
stress.
Treatment
at
70
or
100
μg/mL
significantly
reduced
CuSO4-induced
stress
zebrafish,
demonstrating
strong
activity
β-sitosterol.
protected
against
damage
from
by
upregulating
expressions
sod
gpx4b.
model
inflammation,
pretreatment
before
exposure
inhibited
neutrophil
recruitment
lateral
line
neuromasts,
indicating
potent
effect
derived
reductions
il-8
myd88.
The
results
demonstrate
antioxidative
activities
suggest
that
may
be
useful
for
treatment
various
inflammatory
diseases.
Cells,
Journal Year:
2022,
Volume and Issue:
11(16), P. 2616 - 2616
Published: Aug. 22, 2022
The
second-most
common
cause
of
dementia
is
vascular
(VaD).
majority
VaD
patients
experience
cognitive
impairment,
which
brought
on
by
oxidative
stress
and
changes
in
autophagic
function,
ultimately
result
neuronal
impairment
death.
In
this
study,
we
examine
a
novel
method
for
reversing
VaD-induced
açai
berry
supplementation
mouse
model.
purpose
study
was
to
the
impact
berries
molecular
mechanisms
underlying
model
disease
that
created
repeated
ischemia-reperfusion
(IR)
whole
bilateral
carotid
artery.
Here,
found
able
reduce
behavioral
alteration,
as
well
hippocampal
death,
CA1
CA3
regions.
These
effects
are
probably
due
modulation
nuclear
factor
erythroid
2-related
2
(Nrf-2)
Beclin-1,
suggesting
possible
crosstalk
between
these
pathways.
conclusion,
protective
could
be
good
future
management
dementia.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(3), P. 792 - 792
Published: March 6, 2023
Fibromyalgia
is
a
medical
condition
that
affects
small
percentage
of
the
population,
with
no
known
effective
treatment.
There
evidence
to
suggest
inflammation
key
factor
in
nerve
sensitization
characterizes
disorder.
Therefore,
this
paper
concentrates
on
role
IL-6
fibromyalgia
and
related
pain-like
symptoms.This
work
aimed
evaluate
Sprague-Dawley
rats,
which
were
injected
for
three
consecutive
days
1
mg/kg
reserpine;
IL-6-R
Ab
was
intraperitoneally
at
1.5
seven
after
first
reserpine
injection.
Behavioral
analyses
conducted
beginning
experiment
twenty-one
from
At
timepoint,
animals
sacrificed,
tissues
collected
molecular
histological
analysis.Our
data
showed
analgesic
effect
IL-6-R-Ab
administration
mechanical
allodynia
thermal
hyperalgesia.
Additionally,
+
group
reduced
expression
pain-related
mediators
cFOS
NFG
levels
pro-inflammatory
cytokines
(TNF-α,
IL-1β
IL-6)
chemokines
(Cxcl5,
Cxcl10
Cx3cl1).
From
point
view,
gp130
phosphorylation
activation
Jak/STAT3
pathway.
neuroinflammatory
cells.Our
study
plays
crucial
by
triggering
pathway,
leading
an
increase
chemokine
activating
glial
cells.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
270, P. 115907 - 115907
Published: Jan. 1, 2024
Fluoride
has
strong
electronegativity
and
exposes
diversely
in
nature.
Water
fluoridation
is
the
most
pervasive
form
of
occurrence,
representing
a
significant
threat
to
human
health.
In
this
study,
we
investigate
morphometric
physiological
alterations
triggered
by
fluoride
stimulation
during
embryogenesis
zebrafish
reveal
its
putative
effects
stage-
and/or
dose-dependent.
exhibits
potent
biological
activity
can
be
extensively
absorbed
yolk
sac,
exerting
on
development
multiple
organs.
This
primarily
manifested
as
restricted
nutrient
utilization
elevated
levels
lipid
peroxidation,
further
leading
accumulation
superoxide
liver,
intestines.
Moreover,
pericardial
edema
exerts
pressure
brain
eye
development,
resulting
spinal
curvature
reduced
body
length.
Besides,
acute
exposure
with
varying
concentrations
led
diverse
teratogenic
outcomes.
A
low
dose
water
tends
induce
abnormal
embryonic
while
vascular
malformation
widely
observed
all
fluoride-treated
groups.
The
effect
blood
circulation
universally
present,
even
larvae
that
do
not
exhibit
obvious
deformities.
Their
swimming
behavior
also
affected
fluoridation,
delayed
reactions.
conclusion,
study
provides
valuable
insights
into
monitoring
environmental
quality
related
disease
prevention.
Biology,
Journal Year:
2022,
Volume and Issue:
11(10), P. 1447 - 1447
Published: Oct. 1, 2022
Microalgae
are
rich
in
bioactive
compounds
including
pigments,
proteins,
lipids,
polyunsaturated
fatty
acids,
carbohydrates,
and
vitamins.
Due
to
their
non-toxic
nutritious
characteristics,
these
suggested
as
important
food
for
many
aquatic
animals.
Dunaliella
salina
is
a
well-known
microalga
that
accumulates
valuable
amounts
of
carotenoids.
We
investigated
whether
it
could
restore
the
metabolic
equilibrium
mitigate
hepatic
inflammation
induced
by
zinc
oxide
nanoparticles
(ZnO-NPs)
using
male
zebrafish
which
were
exposed
1/5th
96
h-LC50
4
weeks,
followed
dietary
supplementation
with
D.
at
two
concentrations
(15%
30%)
2
weeks.
Collectively,
ZnO-NPs
affected
fish
appetite,
whole
body
composition,
glycogen
lipid
contents,
intestinal
bacterial
Aeromonas
counts,
well
tumor
necrosis
factor-
α
(TNF-α).
In
addition,
mRNA
expression
genes
related
gluconeogenesis
(pck1,
gys2,
g6pc3),
lipogenesis
(srepf1,
acaca,
fasn,
cd36),
inflammatory
response
(tnf-α,
tnf-β,
nf-kb2)
modulated.
reduced
burden
residues,
restored
appetite
normal
liver
architecture,
mitigated
toxic
impacts
on
whole-body
bacteria,
energy
metabolism,
markers.
Our
results
revealed
administration
might
be
effective
neutralizing
hepatotoxic
effects
model.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(12), P. 2484 - 2484
Published: Dec. 17, 2022
Endometriosis
(Endo)
is
a
chronic
gynecological
disease.
This
paper
aimed
to
evaluate
the
modulation
of
autophagy,
oxidative
stress
and
apoptosis
with
Açai
Berries
in
rat
model
endometriosis.
was
induced
an
intraperitoneal
injection
minced
uterus
tissue
from
donor
into
recipient
one.
The
abdominal
high-frequency
ultrasound
(hfUS)
analysis
performed
at
7
14
days
endometriosis
induction
growth
lesion
during
experiment.
Seven
induction,
once
lesions
were
implanted,
Berry
administered
daily
by
gavage
for
next
seven
days.
At
end
experiment,
hfUS
showed
reduced
diameter
animals
given
Berry.
A
macroscopical
histological
confirmed
this
result.
From
molecular
point
view,
Western
blot
analyses
conducted
autophagy
induction.
Samples
collected
Endo
group
impaired
while
administration
inhibited
PI3K
AKT
ERK1/2
phosphorylation
promoted
inactivating
mTOR.
Additionally,
dephosphorylated
ATG1,
promoting
activity
ATG1/ULK1
complex
that
recruited
Ambra1/Beclin1
Atg9
promote
autophagosome
nucleation
LC3II
expression.
also
restored
mitophagy,
which
increased
Parkin
cytosolic
expression
NRF2
nucleus
its
downstream
antioxidant
proteins
as
NQO-1
HO-1,
thereby
restoring
imbalance.
It
apoptotic
pathway
reducing
BCL-2
increasing
BAX
result
TUNEL
assay.
Overall,
our
results
displayed
able
modulate
