Postępy Biologii Komórki,
Journal Year:
2022,
Volume and Issue:
49(3), P. 207 - 218
Published: Jan. 1, 2022
Modern
medicine
cannot
exist
without
diagnostic
and
therapeutic
methods
that
are
based
on
ionizing
radiation.
Therefore
it
is
necessary
to
understand
interactions
between
this
form
of
energy
living
matter
make
a
full
use
progress
in
radiobiology.
Ionizing
radiation
widely
used
for
relatively
long
time,
how
known,
disproportionately
huge
doses
particularly
harmful
organisms
including
humans.
However
low
useless
modern
medicine.
Broadening
knowledge
radiobiology
can
be
crucial
healthcare
professionals.
Radiation Medicine and Protection,
Journal Year:
2024,
Volume and Issue:
5(1), P. 24 - 29
Published: Jan. 1, 2024
Fast
neutrons
have
sufficient
energy
to
liberate
recoil
protons,
alpha
particles,
and
other
products
when
they
interact
with
the
nuclei
of
target
material
through
scattering
absorption
processes.
Physical
interactions
biological
tissues
occur
mainly
hydrogen
as
protons
in
tissues,
create
dense
ionization
chains
along
their
tracks
thus
depositing
energy.
neutron
therapy
was
pioneered
by
Robert
Stone
1938
a
few
years
after
discovery
neutron.
Its
main
advantage
is
limited
sensitivity
hypoxia
treatment
slow-growing
tumors
hence
better
local
control.
This
where
photon
has
yet
much
success.
Energy
deposition
fast
living
higher
than
conventional
radiotherapy
using
mega
voltage
(MV)
beams.
gives
relative
effectiveness
(RBE)
dealing
certain
tumors.
also
linear
transfer
(LET)
can
reach
deep-sited
therapy.
The
challenge
been
extreme
toxicity
late-reacting
tissues.
Overall,
holds
potential
for
leveraging
unique
interaction
characteristics
review
therefore
intends
bring
this
uniqueness
light
enhance
understanding
radiobiological
properties
advantages
associated
its
Extravasation,
the
unintended
leakage
of
intravenously
administered
substances,
poses
significant
challenges
in
cancer
treatment,
particularly
during
chemotherapy
and
radiotherapy.
This
comprehensive
review
explores
pathophysiology,
incidence,
risk
factors,
clinical
presentation,
diagnosis,
prevention
strategies,
management
approaches,
complications,
long-term
effects
extravasation
patients.
It
also
outlines
future
directions
research
opportunities,
including
identifying
gaps
current
knowledge
proposing
areas
for
further
investigation
management.
Emerging
technologies
therapies
with
potential
to
improve
both
radiotherapy
are
highlighted.
Such
innovations
include
advanced
vein
visualization
technologies,
smart
catheters,
targeted
drug
delivery
systems,
novel
topical
treatments,
artificial
intelligence-based
image
analysis.
By
addressing
these
aspects,
this
not
only
provides
healthcare
professionals
insights
enhance
patient
safety
optimize
practice
but
underscores
importance
ongoing
innovation
improving
outcomes
patients
experiencing
events.
Strahlentherapie und Onkologie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Abstract
Purpose
This
study
aimed
to
assess
the
impact
of
different
energy
levels
on
effectiveness
low-dose
radiotherapy
(LDRT)
for
treating
painful
degenerative
musculoskeletal
diseases,
as
comparative
efficacy
data
are
currently
lacking.
Methods
A
systematic
review
was
conducted
in
PubMed,
Embase,
and
Cochrane
Library
databases
identify
studies
with
response
information
used
(kilovoltage
[kV]
vs.
megavoltage
[MV]).
The
primary
endpoint
overall
rate
(ORR),
secondary
complete
(CRR).
Exploratory
subgroup
analyses
included
treatment
site,
period,
design,
country,
dose
per
fraction.
Results
total
33
involving
12,143
patients
were
analyzed.
Short-term
follow-up
(up
6
months)
showed
a
pooled
ORR
64%
(95%
CI
46–78%)
kV
62%
54–70%)
MV.
Long-term
(at
least
12
revealed
85%
65–95%)
69%
62–75%)
Subgroup
analysis
indicated
no
significant
differences
level
stratified
by
site
other
factors.
Regarding
fraction
(0.5
Gy
1.0
Gy),
comparable
ORRs
demonstrated
between
two
energies.
No
clinical
side
effects
noted.
Conclusion
meta-analysis
suggests
that
known
LDRT
disease
may
not
depend
used.
Additional
using
standardized
evaluation
methods
warranted
establish
consistency
enhance
comprehensiveness
research.
Further
research
is
also
needed
explore
modality
selection
considering
disease-specific
biology.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(11), P. 12244 - 12259
Published: Oct. 30, 2024
This
study
investigates
a
novel
approach
toward
enhancing
the
efficacy
of
Lutetium-177
(Lu-177)
radiopharmaceutical
therapy
by
combining
it
with
gold
nanoparticles
(AuNPs)
in
HepG2
hepatic
cancer
cell
line.
Lu-177,
known
for
its
effective
β
radiation,
also
emits
gamma
rays
at
energies
(113
keV
and
208
keV)
near
photoelectric
absorption
range,
suggesting
potential
targeted
localized
radiation
enhancement
when
used
conjunction
AuNPs.
Thus,
cells
were
treated
two
different
activity
levels
(74
MBq
148
MBq),
Lu-177
alone,
combination
AuNPs
sizes
(10
nm
50
nm),
while
some
received
no
treatment.
Treatment
was
assessed
quantifying
ratio
(RER)
apoptosis
levels.
The
results
reveal
that
significantly
increases
death
compared
to
10
demonstrating
superior
effectiveness.
Additionally,
varying
influenced
treatment
outcomes,
higher
further
augmenting
therapeutic
impact
combined
therapy.
These
findings
underscore
utilizing
Lu-177's
beta,
but
gamma,
emissions,
traditionally
considered
non-therapeutic,
strategy
leverages
as
an
internal
irradiator
exploit
advantage
without
requiring
nanoparticle
functionalization.
provides
promising
improving
radionuclide
sets
stage
future
research
aimed
optimizing
treatments
through
use
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(8)
Published: Nov. 5, 2024
ABSTRACT
Radiation
therapy
is
indispensable
in
medical
practice
but
often
causes
adverse
effects
on
healthy
tissues,
necessitating
the
search
for
natural
radioprotectors.
This
study
investigates
protective
effect
of
Biochanin
A
(BCA)
against
gamma
radiation‐induced
oxidative
stress
and
DNA
damage
Swiss
albino
mice.
Gamma
radiation,
a
potent
ionizing
source,
generates
reactive
oxygen
species
(ROS)
that
cellular
biomolecules,
including
DNA.
Antioxidants
play
crucial
role
neutralizing
ROS
preventing
damage.
mice
were
divided
into
control,
BCA
control
(10
mg/kg
body
weight),
radiation
alone
(7
Gy),
radiation+
pretreatment
groups.
BCA,
isoflavone
with
known
antioxidant
cytoprotective
properties,
was
administered
intraperitoneally
before
exposure.
After
irradiation,
lipid
peroxidation
levels,
enzyme
activities/level
(superoxide
dismutase,
catalase,
glutathione
peroxidase
reduced
glutathione),
expression
levels
repair
genes
(P53,
P21,
GADD45α),
apoptotic
markers
(Bax,
Bcl‐2,
Caspase‐3,
‐9
Cytochrome‐C),
inflammatory
marker
(NF‐κB)
analyzed
small
intestine
tissue.
Our
findings
indicate
significantly
elevated
altered
activities,
indicating
stress.
However,
mitigated
these
by
bolstering
defences,
reducing
Additionally,
markers,
NF‐κB
expression,
promoting
cell
survival
mechanisms.
At
molecular
level,
upregulated
key
repairing
maintaining
genomic
stability.
These
results
underscore
potential
as
radioprotector,
suggesting
its
efficacy
mitigating
preserving
integrity.
In
conclusion,
demonstrates
promising
radioprotective
properties
attenuating
stress,
enhancing
modulating
pathways,
mechanisms
following
Further
research
necessary
to
elucidate
precise
action
explore
therapeutic
applications
oncology
environmental
radioprotection.
Acta Biochimica et Biophysica Sinica,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Nuclear
medicine
therapy
offers
a
promising
approach
for
tumor
treatment,
as
the
energy
emitted
during
radionuclide
decay
causes
irreparable
damage
to
cells.
Notably,
α-decay
exhibits
an
even
more
significant
destructive
potential.
By
conjugating
α-nuclides
with
antibodies
or
small-molecule
inhibitors,
targeted
alpha
(TAT)
can
enhance
destruction
while
minimizing
toxic
side
effects,
making
TAT
increasingly
attractive
antineoplastic
strategy.
Astatine-211
(
Radiation Research,
Journal Year:
2023,
Volume and Issue:
200(6)
Published: Nov. 16, 2023
The
risk
of
exposure
to
high
levels
ionizing
radiation
from
nuclear
weapons
or
radiological
accidents
is
an
increasing
world
concern.
Partial-
total-body
doses
potentially
lethal
through
the
induction
acute
syndrome
(ARS).
Hematopoietic
cells
are
sensitive
exposure;
white
blood
primarily
undergo
apoptosis
while
red
(RBCs)
hemolysis.
Several
laboratories
demonstrated
that
rapid
hemolysis
RBCs
results
in
release
acellular
iron
into
blood.
We
recently
using
a
murine
model
ARS
after
irradiation
(TBI)
and
loss
RBCs,
accumulated
bone
marrow
spleen,
notably
between
4-21
days
postirradiation.
Here,
we
investigated
accumulation
spleens
TBI
nonhuman
primates
(NHPs)
histological
stains.
observed
trends
increased
intracellular
extracellular
brown
pigmentation
various
radiation,
especially
4-15
postirradiation,
but
these
differences
did
not
reach
significance.
significant
increase
Prussian
blue-staining
deposition
spleen
13-15
5.8-8.5
Gy
TBI.
30-60
with
varying
NHP
confirms
our
earlier
findings
model,
showing
Journal of Controlled Release,
Journal Year:
2023,
Volume and Issue:
365, P. 703 - 715
Published: Dec. 7, 2023
Recently,
CRISPR
proteins
have
been
recognized
as
promising
candidates
for
drug
development.
However,
there
is
still
a
lack
of
substances
with
the
appropriate
sensitivity
and
stability
targeted
delivery
systems.
89Zr
radioactive
isotope
that
emits
positrons,
allowing
real-time
in
vivo
tracking
proven
safety.
In
this
study,
we
confirmed
labeling
did
not
compromise
functionality
during
behavioral
imaging.
Furthermore,
demonstrated
therapeutic
efficacy
interference
system
mouse
model
liver
fibrosis,
highlighting
theragnostic
potential
isotope-labeled
proteins.
The
findings
research
could
contribute
to
various
aspects
ongoing
clinical
studies
exploring
applications
Sustainability,
Journal Year:
2024,
Volume and Issue:
16(15), P. 6659 - 6659
Published: Aug. 3, 2024
This
study
presents
issues
related
to
electromagnetic
pollution
and
the
level
of
magnetic
field
radiation
occurring
around
conductors
used
for
electricity
transmission
distribution.
The
fact
that
modeling
simulation
are
most
efficient
methods
optimization,
considering
cost–benefit
ratio,
was
premise
this
work.
paper
proposes
performance
a
complex
analysis,
carried
out
in
comparative
manner,
which
includes
physical
tests
simulations
existing
distribution
cables
transformer
substations.
In
first
stage,
near
conductor
by
an
electric
current
tested
(measured),
virtual
model
then
designed
simulate
conditions
similar
those
test.
results
obtained
from
were
analyzed
comparison
with
testing.
maximum
permissible
limits
exposure
field,
regulated
Government
Decision
HG
520/2016
20
July
2016
Directive
2013/35/EU
European
Parliament
Council
26
June
2013,
as
reference
formulate
conclusions
both
situations
considered.
These
comparisons
intended
determine
fields
places
where
transmission/distribution
located.
Energy
sustainability
exists
due
versatile
properties
conductors,
energy
network
being
functional
regardless
source
production.
