Environmental Exposure to Persistent Organic Pollutants and Its Association with Endometriosis Risk: Implications in the Epithelial–Mesenchymal Transition Process

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4420 - 4420

Published: April 17, 2024

We aimed to explore the relationship of adipose tissue concentrations some persistent organic pollutants (POPs) with risk endometriosis and endometriotic expression profile genes related endometriosis-related epithelial–mesenchymal transition (EMT) process. This case–control study enrolled 109 women (34 cases 75 controls) between January 2018 March 2020. Adipose samples tissues were intraoperatively collected determine nine POPs gene profiles 36 EMT-related genes, respectively. Associations explored multivariate logistic regression, while exposure was assessed through Spearman correlation or Mann–Whitney U tests. After adjustment, increased associated p,p’-DDT, PCB-180, ΣPCBs. POP also reduced levels CLDN7 epithelial marker ITGB2 mesenchymal a variety EMT promoters (HMGA1, HOXA10, FOXM1, DKK1, CCR1, TNFRSF1B, RRM2, ANG, ANGPT1, ESR1). Our findings indicate that may increase might have role in development, contributing disease onset progression. Further studies are warranted corroborate these findings.

Language: Английский

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Covalent organic frameworks and metal–organic frameworks for sustainable adsorptive removal/extraction of dirty dozen chemicals: A review

Journal of the Chinese Chemical Society, Journal Year: 2024, Volume and Issue: 71(9), P. 978 - 1007

Published: July 24, 2024

Abstract Dirty dozen chemicals (DDCs) are a group of 12 extremely toxic that were recognized at the Stockholm convention in 2001 for their severe impact on ecosystem and human health. Despite embargo restraint placed DDCs usage, these continue to find way into because they still secretly or openly applied by many nations, especially African regions. Moreover, can be perceived where have been employed previously before treaty due persistent profile. This study aimed critically review original works directed toward removal various dirty using covalent metal–organic frameworks (COFs MOFs). Specifically, this study, COFs/MOFs composites with remarkably tailored adsorptive profiles evaluated adsorption efficiency different DDCs. In addition, effect operating parameters importance environmentalists stakeholders optimization purposes was empirically discussed. also fills knowledge vacuums about COF/MOF‐DDCs process, offers insights reusability potential, fundamental mechanism, isotherm, kinetic modeling, framework future studies. Findings from revealed COF MOF high DDC capacity potential attributed admirable porosity existence plethora oxygen‐rich functional groups allow better interactions through chelation, halogen bonding, H‐bonding, π‐π stacking. points upscaling remediation technique. Future researchers need direct more efforts use density theory mechanism interpretation, exploration hybrid technology, cost analysis, scalability, thermodynamics, adsorption, desorption modeling.

Language: Английский

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The Impact of Chemical Residues in Meat Products on Human Nutritional and Health

Natural and Engineering Sciences, Journal Year: 2025, Volume and Issue: 10(1), P. 425 - 435

Published: April 1, 2025

This study aimed to identify specific chemical pollutants in sausages, lunch meat, minced and burgers. In all, 172 meat product samples (43 of each burger, sausage) were gathered from several local markets the Iraqi provinces Baghdad Babil. The quantities progesterone, zeranol, trenbolone hormone residues, Additionally, samples' levels pesticide residues tested. mean values 1.0055, 0.6166, 0.8222 ppb for sausage, luncheon respectively, occurrence zeranol residue burgers was zero 100%. Trenbolone traces found every sample that examined, including beef, corresponding these 0.2372, 0.3181, 0.3094, 0.3261 ppb. Progesterone measured sausage analyzed. 0.0638, 0.0827, 0.0455, 0.0366 ppb, respectively. All analyzed burgers, sausages had PP.DDT are them. Minced beef a higher PP than other sample's DDT value (2.9880 ppm). Only burger methoxychlor with 49.5820 48.9938 ppm; did not have residues—however, PP. DDE absent sample. their DDD recorded 0.872, 0.903, 0.914, 0.982. As result, we must regularly check like hormones as precautionary measure food quality pesticides certain products since present severe danger public health.

Language: Английский

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Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

Toxics, Journal Year: 2024, Volume and Issue: 12(3), P. 183 - 183

Published: Feb. 28, 2024

Efforts are being made globally to improve the evaluation and understanding of endocrine-disrupting chemicals. Recognition their impact on human health environment has stimulated attention research in this field. Various stakeholders, including scientists, regulatory agencies, policymakers, industry representatives, collaborating develop robust methodologies guidelines for assessing these disruptors. A key aspect efforts is development standardized testing protocols that aim provide consistent reliable methods identifying characterizing endocrine When evaluating potential activity chemicals, no single test capable detecting all relevant agents. The battery approach designed reduce risk false negative results compounds with toxic potential. weight-of-evidence therefore necessary disruptor evaluation. This considers various types data from multiple sources, overall strength, consistency, reliability evidence. OECD highly regarded scientific rigor, transparency, consensus-based process. It crucial explore new can effectively evaluate risks associated Integrating into a comprehensive framework will enhance assessments facilitate informed decisions regarding regulation management substances, ensuring protection adverse effects.

Language: Английский

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Persistent Organic Pollutants in Water and their Microalgae Based Bioremediation

Biosciences Biotechnology Research Asia, Journal Year: 2024, Volume and Issue: 21(3), P. 913 - 928

Published: Sept. 30, 2024

ABSTRACT: This appraisal overviews Persistent Organic Pollutants and suggests a novel approach to their bioremediation using algae as an agent. Compared older techniques different bacteria, greenway for wastewater treatment is more environmentally sustainable friendlier. It has lot of potential use new technology that uses cyanobacteria remove variety organic pollutants. Several organisms' health well-being may be at risk due the abundance pollutants in environment. Household garbage, agriculture, industry are some numerous man-caused contributors pollute water across planet. Wastewater needs cleaned before it discharged into rivers. As algae-based systems don't produce any secondary sustainable, they growing popularity. A can absorbed accumulated by rates, contingent upon type contaminant, physio-chemical assets waste water, well specific species involved. Moreover, phytoremediation affordable option breaking down than traditional methods. Algal biomass produced through phycoremediation might also play significant role bioenergy value chain. Hence emphasis this paper on over view Pollutants, microalgae species, which have rid several

Language: Английский

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Contaminantes orgánicos persistentes: Impactos y medidas de control

Manglar, Journal Year: 2024, Volume and Issue: 21(1), P. 135 - 148

Published: April 2, 2024

Los contaminantes orgánicos persistentes (COP) representan un problema ambiental significativo debido a su toxicidad, con una alta capacidad para persistir en el entorno, resistencia los métodos de degradación convencionales, la acumulación organismos vivos y magnificación las cadenas tróficas o alimentarias. En este artículo revisión, se examinan impactos salud componentes medio ambientales. También abordan estrategias medidas control, mitigación y/o minimización COP. Se identifica actividades agrícolas, industriales, inadecuada disposición final residuos sólidos falta tratamiento aguas residuales como principales fuentes emisión Además, analizan tecnologías innovadoras prometedoras, nanotecnología, biorremediación, rizorremediación, biocarbón, técnicas cromatografía, ultrasonido, entre otras, adecuado La revisión destaca tanto ventajas limitaciones estas tecnologías, señalando áreas que aún requieren desarrollos lograr tratamientos eficaces. mencionan alternativas más económicas ecológicas, contrarrestar

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Impact of DDT on women's health in Bangladesh: escalating breast cancer risk and disturbing menstrual cycle

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 12, 2024

Impact of DDT on women's health in Bangladesh: escalating breast cancer risk and disturbing menstrual cycle

Language: Английский

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Review on Organochlorine Pollution in Malaysia

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 32 - 44

Published: March 4, 2024

Organochlorine is a type of persistent organic pollutants which can last long in environment due to the resistance towards microbial degradation. Previously, organochlorine pesticides are widely used reduce pests farm so, crop yield could be increased, and losses decreased. The previously without having proper study on effect environment. Although use has been banned, residues from previous usage, still exist environment, causing negative impacts human health. distribution pollution Malaysia required studied more ensure that concentration will not increasing according time. Due ban pesticides, other control methods such as organophosphate integrated pest management being by farmers. However, there challenges raised financial problem farmers afford new chemicals or chemicals, these should solved improve Malaysia. Impacts organochlorines health discussed this review show hazard organochlorines.

Language: Английский

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Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 289, P. 117463 - 117463

Published: Dec. 6, 2024

Language: Английский

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Xenobiotics: Effects of Unnatural Chemicals on the Environment

Published: June 7, 2024

In recent years, Pleurotus ostreatus is the most cultivated mushroom in our country after Agaricus bisporus. this study, problems observed small-scale businesses Oyster mushrooms, which a new investment area for country, will be discussed and solution suggestions emphasized.

Language: Английский

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