Oxidative stress-related biomarkers as forensic biomarkers for burned skin vitality in rats DOI Creative Commons
Ola A. Habotta, Ahmed Ateya, Ahmed Abdeen

et al.

Mansoura Veterinary Medical Journal, Journal Year: 2023, Volume and Issue: 24(3)

Published: Jan. 1, 2023

Objective: In forensic practice, the diagnosis of whether a skin injury is inflicted in life or not challenging research topic. Therefore, new reliable biomarkers vitality are urgently required. this study, biochemical, molecular and histopathological techniques were used to explore role oxidative stress differentiating antemortem from postmortem burn injury. Design, animals procedures: Eighteen male rats allocated three groups: normal unburnt group, group group. Results: The analysis specimens revealed notable increase MDA levels together with decrease GSH TAC both burnt groups compared controls. results marked upregulation Nrf-2 downregulation Keap-1 gene expression under thermal These significantly higher vital burns than burns. Conclusion clinical relevance: Our findings suggest that cellular markers helpful tools for reaction.

Language: Английский

Oxidative stress-related biomarkers as forensic biomarkers for burned skin vitality in rats DOI Creative Commons
Ola A. Habotta, Ahmed Ateya, Ahmed Abdeen

et al.

Mansoura Veterinary Medical Journal, Journal Year: 2023, Volume and Issue: 24(3)

Published: Jan. 1, 2023

Objective: In forensic practice, the diagnosis of whether a skin injury is inflicted in life or not challenging research topic. Therefore, new reliable biomarkers vitality are urgently required. this study, biochemical, molecular and histopathological techniques were used to explore role oxidative stress differentiating antemortem from postmortem burn injury. Design, animals procedures: Eighteen male rats allocated three groups: normal unburnt group, group group. Results: The analysis specimens revealed notable increase MDA levels together with decrease GSH TAC both burnt groups compared controls. results marked upregulation Nrf-2 downregulation Keap-1 gene expression under thermal These significantly higher vital burns than burns. Conclusion clinical relevance: Our findings suggest that cellular markers helpful tools for reaction.

Language: Английский

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