In Vitro and In Vivo Genotoxicity of Polystyrene Microplastics: Evaluation of a Possible Synergistic Action with Bisphenol A DOI Creative Commons
Alfredo Santovito, Mattia Lambertini, Alessandro Nota

et al.

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(4), P. 1415 - 1431

Published: Oct. 8, 2024

The ubiquitous presence of plastics represents a global threat for all ecosystems and human health. In this study, we evaluated, in vitro vivo, the genotoxic potential different concentrations polystyrene microplastics (PS-MPs) their possible synergistic interactions with bisphenol-A (BPA). For vivo assays, used lymphocytes hemocytes from

Language: Английский

Genotoxicological and physiological effects of glyphosate and its metabolite, aminomethylphosphonic acid, on the freshwater invertebrate Lymnaea stagnalis DOI

Dáša Schleicherová,

Paolo Pastorino,

Alessia Pappalardo

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 271, P. 106940 - 106940

Published: May 6, 2024

Language: Английский

Citations

4
Cellular and Genomic Instability Induced by the Herbicide Glufosinate-Ammonium: An In Vitro and In Vivo Approach DOI Creative Commons
Alfredo Santovito, Mattia Lambertini,

Dáša Schleicherová

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 909 - 909

Published: May 24, 2024

Glufosinate-ammonium (GLA), an organophosphate herbicide, is released at high concentrations in the environment, leading to concerns over its potential genotoxic effects. However, few articles are available literature reporting possible cellular and nuclear effects of this compound. We assessed, by vitro vivo micronucleus assays, genotoxicity GLA on cultured human lymphocytes Lymnaea stagnalis hemocytes six concentrations: 0.010 (the established acceptable daily intake value), 0.020, 0.050, 0.100, 0.200, 0.500 µg/mL. In lymphocytes, our results reveal a significant concentration-dependent increase micronuclei frequency from 0.100 μg/mL, while L. hemocytes, differences were found 0.200 μg/mL. A reduction proliferation index was observed all tested concentrations, with only exception indicating that exposure could lead increased cytotoxic stagnalis, laid eggs body growth also concentrations. conclusion, we provided evidence genomic damage induced both model organism’s hemocytes; addition, demonstrated cell reproductive health stagnalis.

Language: Английский

Citations

4
Ecotoxicological effects of sunscreen derived organic and inorganic UV filters on marine organisms: A critical review DOI Creative Commons
Angela Hodge, Frances E. Hopkins, Mahasweta Saha

et al.

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 213, P. 117627 - 117627

Published: Feb. 11, 2025

Sunscreens are topical personal care products that provide protection against the sun's ultraviolet A (UVA) and B (UVB) radiation. Ultraviolet (UV) filters compounds added to sunscreens block, absorb, or reflect UV rays, but of major emerging concern due their widespread use global distribution. They pose a significant risk marine organisms owing chemical properties, including high lipophilicity which increases bioavailability. The present review identifies summarises factors contribute filter pollution, sources, pathways, effects on organisms. We identify evaluate current knowledge base gaps pertaining effects. Here, we retrieved 111 peer-reviewed articles from four academic search engines between January October 2024 with topic relating filters, sunscreen ecotoxicology. Most publications (60 %) focused biological organic oxybenzone (benzophenone-3) being most studied (57 %). Fewer assessed inorganic (40 Throughout all results, commonly tested species were in class bivalvia (24 oxidative stress based assays popular (organic studies 40 %, studies, 39 To enhance understanding, future research should explore broader range life stages, considering dietary uptake realistic environmental conditions, lighting laboratory settings.

Language: Английский

Citations

0
Effects of benzophenone-3 on the liver and thyroid of adult zebrafish DOI

Felismário Medeiros da Silva,

Renan Pena Modesto,

Marco Lira

et al.

Xenobiotica, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 7

Published: Nov. 13, 2024

1. Benzophenone-3 (BP-3), commonly known as oxybenzone, is an organic compound that acts a sunscreen, protecting the skin from UVA and UVB rays. Thus, objective of this study was to investigate effects BP-3 on liver thyroid using morphological biochemical approaches.

Language: Английский

Citations

1
In Vitro and In Vivo Genotoxicity of Polystyrene Microplastics: Evaluation of a Possible Synergistic Action with Bisphenol A DOI Creative Commons
Alfredo Santovito, Mattia Lambertini, Alessandro Nota

et al.

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(4), P. 1415 - 1431

Published: Oct. 8, 2024

The ubiquitous presence of plastics represents a global threat for all ecosystems and human health. In this study, we evaluated, in vitro vivo, the genotoxic potential different concentrations polystyrene microplastics (PS-MPs) their possible synergistic interactions with bisphenol-A (BPA). For vivo assays, used lymphocytes hemocytes from

Language: Английский

Citations

0